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| 1 | Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair显示文摘间充质的干细胞(MSC ) 为治疗各种各样的疾病有大潜力,特别那些与织物有关损坏包含有免疫力的反应。各种各样的研究证明了 MSC 在 vitro 并且在 vivo 是强烈抑制免疫力的。我们的最近的研究证明了那未刺激的 MSC 确实不能免疫力的抑制;他们与 TNF- 伪, IL-1 伪或 IL-1 尾与激活的淋巴细胞的上层清液,或与 IFN- 纬的联合在刺激之上变得 potently 抑制免疫力。这观察表明在某些情形下面,煽动性的 cytokines 能实际上变得抑制免疫力。我们证明在调停 MSC 的免疫力的抑制的机制有一个种类变化:由告知 cytokine 的老鼠 MSC 的免疫力的抑制被氮的氧化物调停(没有) 而由告知 cytokine 的人的 MSC 的免疫力的抑制通过 indoleamine 被执行 2, 3-dioxygenase (伊多语) 。在有煽动性的 cytokines 的刺激之上,另外,老鼠和人的 MSC 分泌几白血球 chemokines 显然服务与 MSC 吸引有免疫力的房间进最近,在哪儿不或伊多语被预言很活跃。因此,由煽动性的刺激 cytokine 的 MSC 的免疫力的抑制经由 chemokines 的一致行动发生并且免疫者禁止没有或伊多语由 MSC 生产了。因此,我们的结果在对待有免疫力的回答导致的织物损害关于调停 MSC 的免疫力的抑制并且为 MSC 的更好的申请的机制提供新奇信息。 | Yufang Shi Gangzheng Hu Juanjuan Su Wenzhao Li Qing Chen Peishun Shou Chunliang Xu Xiaodong Chen Yin Huang Zhexin Zhu Xin Huang Xiaoyan Han Ningxia Xie Guangwen Ren | 2010 | Cell Research2010，20，5： | 72 |
| 2 | Function of lncRNAs and approaches to lncRNA-protein interactions显示文摘Long non-coding RNAs(lncRNAs),which represent a new frontier in molecular biology,play important roles in regulating gene expression at epigenetic,transcriptional and post-transcriptional levels.More and more lncRNAs have been found to play important roles in normal cell physiological activities,and participate in the development of varieties of tumors and other diseases.Previously,we have only been able to determine the function of lncRNAs through multiple mechanisms,including genetic imprinting,chromatin remodeling,splicing regulation,mRNA decay,and translational regulation.Application of technological advances to research into the function of lncRNAs is extremely important.The major tools for exploring lncRNAs include microarrays,RNA sequencing(RNA-seq),Northern blotting,real-time quantitative reverse transcription-polymerase chain reaction(qRT-PCR),fluorescence in situ hybridization(FISH),RNA interference(RNAi),RNA-binding protein immunoprecipitation(RIP),chromatin isolation by RNA purification(ChIRP),crosslinking-immunopurification(CLIP),and bioinformatic prediction.In this review,we highlight the functions of lncRNAs,and advanced methods to research lncRNA-protein interactions. | ZHU JuanJuan FU HanJiang WU YongGe ZHENG XiaoFei | 2013 | Science China(Life Sciences)2013，56，10： | 54 |
| 3 | A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy显示文摘anti-CTLA-4 抗体由阻止 B7-CTLA-4 相互作用接近否定发信号引起肿瘤拒绝,这被假定。在比临床上有效的 dosing 完成的血浆层次更加高的集中,令人惊讶地, anti-CTLA-4 抗体 Ipilimumab 不由 CTLA-4 也不 CTLA-4 绑定堵住任何一 B7 trans-endocytosis 到使不能调动或联系房间的 B7。因而, Ipilimumab 不从人性化的任何一个 CTLA4 基因在树枝状的房间(DC ) 上增加 B7 (Ctla4 h/h ) 或人的 CD34 + 茎重新组成房间的 NSG 老鼠。在 Ctla4 高效地表示人和老鼠 CTLA4 基因,绑在人的 anti-CTLA-4 抗体然而并非老鼠 CTLA-4 的 h/m 老鼠导致 Treg 弄空和 Fc 受体依赖者肿瘤拒绝。堵住的抗体 L3D10 比得上在引起肿瘤拒绝的非阻塞的 Ipilimumab。显著地,输在人类化期间堵住活动的 L3D10 子孙在导致 Treg 弄空和肿瘤拒绝仍然保持充分能干。有效地在淋巴的器官堵住 CD4 T 细胞激活和 de novo CD8 T 细胞 priming 的 Anti-B7 抗体否定地不影响 Ipilimumab 的 immunotherapeutic 效果。因此,临床上有效的 anti-CTLA-4 mAb 由独立于检查点封锁的机制引起肿瘤拒绝但是依赖于主人 Fc 受体。我们为 CTLA-4 检查点的一个重评价的数据电话封锁假设并且为安全、有效的 anti-CTLA-4 mAbs 的下一代提供新卓见。 | Xuexiang Du Fei Tang Mingyue Liu Juanjuan Su Yan Zhang Wei Wu Martin Devenport Christopher A Lazarski Peng Zhang Xu Wang Peiying Ye Changyu Wang Eugene Hwang Tinghui Zhu Ting Xu Pan Zheng Yang Liu | 2018 | Cell Research2018，28，4： | 25 |
| 4 | The Flowering Repressor SVP Confers Drought Resistance in Arabidopsis by Regulating Abscisic Acid Catabolism显示文摘陆上的植物必须应付干旱应力幸存。在干旱应力下面,植物由增加它的生合成并且减少积累植物激素 abscisic 酸(骆驼毛的织物) 它的分解代谢。然而,响应干旱控制骆驼毛的织物分解代谢的规章的小径仍然保持大部分不清楚。这里,我们报导 flowering 抑压者短植物的阶段(SVP ) 被干旱应力和伙伴与 ABA 分解代谢小径基因 CYP707A1, CYP707A3 和 AtBG1 的倡导者区域导致,引起 CYP707A1 和 CYP707A3 的减少的表示但是在 Arabidopsis 的 AtBG1 的提高的表示离开。在 AtBG1 的 CYP707A1 和 CYP707A3 或 overexpression 的 Loss-of-function 变化能由增加细胞的骆驼毛的织物层次救 svp 异种植物的干旱过分敏感的显型。一起,我们的结果建议 SVP 是骆驼毛的织物分解代谢的一个中央管理者 ? 并且包含 SVP, CYP707A1/3,和 AtBG1 的一条规章的小径在植物反应起一个关键作用浇赤字和植物干旱抵抗。 | Zhen Wang Fuxing Wang Yechun Hong Juanjuan Yao Zhizhong Ren Huazhong Shi Jian-Kang Zhu | 2018 | Molecular Plant2018，11，9： | 12 |
| 5 | Geochemistry of hydrothermal gold deposits:A review显示文摘在热水的改变期间形成的矿物质集合反映形成矿石的液体的 geochemical 作文。黄金主要作为 AuCl 和 AuS 建筑群在答案被搬运。象温度,压力,氧易逃逸,和硫易逃逸那样的物理化学的条件的变化是为金降水的有效机制。黄金趋于在高温度和压力在液体的蒸汽阶段被专注。AuAs 和 AuSb 协会在金沉积物是普通的。本国的锑或砷土著人金牌集合可以与低硫易逃逸从热水的液体猛抛。形成 epithermal 金牌沉积物的热水的液体在大多数情况中是浸透 Au 的,而巫婆类型的液体是 Au-undersaturated。从通过吸收的热水的液体的伪稳定的同样忍受的黄铁矿摘录固体答案 Au。同样忍受的黄铁矿的能力从下面浸透的液体吸收 Au 是大规模巫婆类型沉积物的形成的关键。与增加新数据,金存款的地球化学上的研究能被用来跟踪形成矿石的液体,黄金的来源,和 Au 和另外的形成矿石的元素的搬运形式的起源,例如 Si, S, F, Cl,并且 Ag。 | Yongfeng Zhu Fang An Juanjuan Tan | 2011 | Geoscience Frontiers2011，2，3： | 12 |
| 6 | Modifi cation of wheat bran insoluble and soluble dietary fibers with snail enzyme显示文摘Insoluble dietary fiber(IDF)and soluble dietary fiber(SDF)extracted from wheat bran were modifi ed by snail enzyme and their physicochemical properties(water retention capacity and oil retention capacity),functional properties(cholesterol adsorption capacity,glucose adsorption capacity and antioxidant activity)and structural characterizations were evaluated.The results showed that snail enzyme modification led to the significant increase in oil retention capacity of IDF,glucose adsorption capacity and cholesterol adsorption capacity of IDF and SDF.Enzymatic modification also markedly improved the DPPH radical scavenging capacity and reducing power of IDF and SDF.Meanwhile,scanning electron microscopy(SEM)analysis indicated the microstructures of IDF and SDF powders were signifi cantly changed.Fourier transfer-infrared spectrometry(FT-IR)showed that snail enzyme modifi cation could degrade the part of cellulose and hemicellulose of IDF and SDF.All these improved physicochemical and functional properties of IDF and SDF might depend on their structural changes.It suggested that snail enzyme modifi cation could effectively improve physicochemical and functional properties of IDF and SDF from wheat bran. | Xin Liu Keke Suo Pei Wang Xue Li Limin Hao Jiaqing Zhu Juanjuan Yi Qiaozhen Kang Jinyong Huang Jike Lu | 2021 | Food Science and Human Wellness2021，10，3： | 10 |
| 7 | A novel nonviral nanoparticle gene vector: Poly-L-lysine- silica nanoparticles显示文摘DNA delivery is a core technology for gene structure and function research as well as clinical settings. The ability to safely and efficiently targeted transfer foreign DNA into cells is a fundamental goal in biotechnology. With the development of nanobiotechnology, nanoparticle gene vectors brought about new hope to reach the goal. In our research, silica nanoparticles (SiNP) were synthesized first in a microemulsion system polyoxyethylene nonylphenyl ether (OP-10)/cyclohexane/ammonium hydroxide, at the same time the effects of SiNP size and its distribution were elucidated by orthogonal analysis; then poly-L-lysine (PLL) was linked on the surface of SiNP by nanoparticle surface energy and electrostatically binding; lastly a novel complex nanomate-rial-poly-L-lysine-silica nanoparticles (PLL-SiNP) wasprepared. The analysis of plasmid DNA binding and DNase I enzymatic degradation discovered that PLL-SiNP could bind DNA, and protect it against enzymatic degradation. Cell transfection showed that | Shiguo Zhu Hongbin Lu Juanjuan Xiang Ke Tang Bicheng Zhang Ming Zhou Chen Tan Guiyuan Li | 2002 | Chinese Science Bulletin2002，47，8： | 9 |
| 8 | Electronic image stabilization system based on global feature tracking显示文摘A new robust electronic image stabilization system is presented, which involves feature-point, tracking based global motion estimation and Kalman filtering based motion compensation. First, global motion is estimated from the local motions of selected feature points. Considering the local moving objects or the inevitable mismatch, the matching validation, based on the stable relative distance between the points set is proposed, thus maintaining high accuracy and robustness. Next, the global motion parameters are accumulated for correction by Kalman filter-ation. The experimental result illustrates that the proposed system is effective to stabilize translational, rotational, and zooming jitter and robust to local motions. | Zhu Juanjuan Guo Baolong | 2008 | Journal of Systems Engineering and Electronics2008，19，2： | 7 |
| 9 | Distinct roles of ASIC3 and TRPV1 receptors in electroacupuncture-induced segmental and systemic analgesia显示文摘 | Juanjuan Xin Yangshuai Su Zhaokun Yang Wei He Hong Shi Xiaoyu Wang Ling Hu Xiaochun Yu Xianghong Jing Bing Zhu | 2016 | Frontiers of Medicine2016，10，4： | 5 |
| 10 | Synchronous chirp mode extraction: A promising tool for fault diagnosis of rolling element bearings under varying speed conditions显示文摘As critical components in modern aerospace productions,rolling element bearings(REBs)generally work under varying speed conditions,which brings great challenges to their operating health monitoring.Some novel time–frequency decomposition(TFD)algorithms are established recently to extract nonlinear features from the non-stationary signals effectively,which are promising for realizing fault diagnosis of REBs under varying speed conditions.However,numerous personal experiences must be incorporated and the anti-noise performance of these methods needs to be further enhanced.Given these issues,a synchronous chirp mode extraction(SCME)-based REB fault diagnosis method is proposed for the health monitoring of REBs under varying speed conditions in this study.It mainly consists of following two parts.(a)The shaft rotational frequency(SRF)is initially estimated from the low-frequency band of the vibration signal.Simultaneously,an adaptive refining strategy is incorporated to obtain a suitable bandwidth parameter.(b)A cycle-one-step estimation frame is constructed to extract synchronous modes from the envelope waveform of the vibration signal.Meanwhile,a synchronous mode spectrum(SMS)is generated using the information of the extracted synchronous modes,which is a novel REBs fault diagnosis technique with tacholess and resampling-free.In contrast to the current TFD algorithms,the proposed method needs fewer input parameters and owns a well anti-noise performance because there is no iterative optimization in the procedure of construction of SMS.As a result,the health conditions of REBs are evaluated by detecting the exhibited features in the SMS.Simulations and experiments are conducted to validate the effectiveness of the proposed method in terms of REB fault diagnosis.Analysis results demonstrate that the proposed method outperforms the current TFD algorithm and the conventional order tracking technique for fault diagnosis of REB under varying speed conditions. | Xingxing JIANG Qiang HUANG Changqing SHEN Qian WANG Kun XU Jie LIU Juanjuan SHI Zhongkui ZHU | 2022 | Chinese Journal of Aeronautics2022，35，1： | 3 |
| 11 | Restricted peri-operative fluid administration adjusted by serum lactate level improved outcome after major elective surgery for gastrointestinal malignancy显示文摘 | Yu WenKui Li Ning Gong JianFeng Li WeiQin Tang ShaoQiu Tong Zhihui Gao Tao Zhang JuanJuan Xi FengChan Shi Hui Zhu WeiMing Li Jie-Shou | 2010 | Surgery2010，，4： | 2 |
| 12 | miR-23a/b suppress cGAS-mediated innate and autoimmunity显示文摘Cyclic GMP-AMP synthase(cGAS),a key sensor of intracellular DNA,is essential for eliciting innate immunity against infection,whereas aberrant activation of cGAS by endogenous DNA promotes severe autoimmune diseases.However,it is largely unknown how cGAS expression is regulated during pathogen infection and autoimmunity.Here,we report that during herpes simplex virus type 1(HSV-1)infection,two microRNAs(miR-23a and miR-23b)whose levels significantly decrease due to their interaction with the lncRNA Oasl2-209 directly regulate the expression of cGAS.Overexpression of miR-23a/b markedly dampens cytosolic DNA-induced innate immune responses,whereas inhibition of miR-23a/b enhances these responses.Mice treated with miR-23a/b agomirs exhibit increased susceptibility to HSV-1 infection.Moreover,cGAS is significantly upregulated in the Trex1^(−/−)mouse autoimmune disease model.Administration of miR-23a/b blunts self DNA-induced autoinflammatory responses in Trex1^(−/−)mice.Collectively,our study not only reveals a novel regulatory mechanism of cGAS expression by miRNAs but also identifies a potential therapy for cGAS-related autoimmune diseases. | Qiuya Yu Lei Chu Yongxing Li Quanyi Wang Juanjuan Zhu Chen Wang Shufang Cui | 2021 | Cellular & Molecular Immunology2021，18，5： | 2 |
| 13 | Study on tribological behavior of water-lubricated bearings显示文摘 | Hua Xijin Wang Jiaxu Zhu Juanjuan | | 0，，01： | 1 |
| 14 | Study on tribological behavior of water-lubricated bearings 显示文摘 | Hua Xijin Wang Jiaxu Zhu Juanjuan | 2008 | Journal of Advanced Manufacturing Systems2008，7，1： | 1 |
| 15 | The Arabidopsis spliceosomal protein SmEb modulates ABA responses by maintaining proper alternative splicing of HAB1显示文摘Abscisic acid(ABA)signaling is critical for seed germination and abiotic stress responses in terrestrial plants.PremRNA splicing is known to regulate ABA signaling.However,the involvement of canonical spliceosomal components in regulating ABA signaling is poorly understood.Here,we show that the spliceosome component Sm core protein SmEb plays an important role in ABA signaling.SmEb expression is up-regulated by ABA treatment,and analysis of Arabidopsis smeb mutant plants suggest that SmEb modulates the alternative splicing of the ABA signaling component HAB1 by enhancing the HAB1.1 splicing variant while repressing HAB1.2.Overexpression of HAB1.1 but not HAB1.2 rescues the ABA-hypersensitive phenotype of smeb mutants.Mutations in the transcription factor ABI3,4,or 5 also reduce the ABA hypersensitivity of smeb mutants during seed germination.Our results show that the spliceosomal component SmEb plays an important role in ABA regulation of seed germination and early seedling development. | Yechun Hong Juanjuan Yao Huazhong Shi Yunjuan Chen Jian-Kang Zhu Zhen Wang | 2021 | Stress Biology2021，1，1： | 1 |
| 16 | Advances in research of land surface evapotranspiration at home and abroad显示文摘Land surface evapotranspiration (ET) is an important part of the hydrologic cycle and energy balances.With the development of remote sensing technology,research on monitoring and estimating of evapotranspiration has made important progress.This paper summarizes advances in measuring and estimating regional evapotranspiration at home and abroad based on traditional methods and remote sensing.This summary includes such methods as Bowen,Gradient,Penman-Monteith,Water Balance,Eddy Correlation,SPAC,Energy Balance and Remote Sensing.Also,the evapotranspiration achievements in the Heihe River Basin are also discussed.Finally,the existing problems in regional evapotranspiration research and future development prospects are also discussed at the conclusion of this paper. | XinPing Luo KeLi Wang Hao Jiang Jia Sun JuanJuan Xu QingLiang Zhu ZhaoGuo Li | 2010 | Research in Cold and Arid Regions2010，2，2： | 1 |
| 17 | Interruptible load included reserve procurement method with wind power integration 显示文摘 | Zhao Yunli Zhu Quansheng Wang Juanjuan | 2012 | International Review of Electrical Engineering2012，7，3： | 1 |
| 18 | Study on tribological behavior of water-lubricated bearings 显示文摘 | Hua Xijin Wang Jiaxu Zhu Juanjuan | 2008 | Joural of Advanced Manufacturing Systems2008，7，1： | 1 |
| 19 | Concentrations and characteristics of selenium in soil samples from Dashan Region, a selenium-enriched area in China显示文摘 | Kun Xing Shoubiao Zhou Xiaoguo Wu Yuanyuan Zhu Juanjuan Kong Ting Shao Xu Tao | 2015 | Soil Science and Plant Nutrition2015，，6： | 1 |
| 20 | Vitrified-warmed blastocyst transfer cycles yield higher pregnancy and implantation rates compared with fresh blastocyst transfer cycles—time for a new embryo transfer strategy?显示文摘 | Dandan Zhu Juanjuan Zhang Shanren Cao Junqiang Zhang Boon Chin Heng Meiling Huang Xiufeng Ling Tao Duan Guo Qing Tong | 2011 | Fertility and Sterility2011，，5： | 1 |
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