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| 1 | On Improved DV-Hop Localization Algorithm for Accurate Node Localization in Wireless Sensor Networks显示文摘Node Localization is a fundamental issue for many critical applications in Wireless sensor networks(WSNs). Traditional DV-Hop localization algorithm and corresponding improved ones still cannot provide sufficient localization accuracy in such WSNs. To ensure accurate localization, this paper proposes an improved Distancevector-Hop(DV-Hop) localization algorithm. Under such an algorithm, we determine a corrected average hopdistance of beacon nodes by employing the differences between actual and estimated distance among beacon nodes in WSNs. We propose a probability information based selective strategy for the selection of beacon nodes.Based on these selected beacon nodes, we adopt a two dimensional hyperbolic function to predict the locations of unknown nodes. Simulation results are provided to illustrate the localization accuracy of our algorithm compared with traditional DV-Hop algorithm and its two improved algorithms in WSNs. | SHEN Shikai YANG Bin QIAN Kaiguo SHE Yumei WANG Wu | 2019 | Chinese Journal of Electronics2019，28，3： | 15 |
| 2 | Gli-1 siRNA induced apoptosis in Huh7 cells显示文摘AIM: To investigate the effects of Gli-1 small interference RNA (siRNA) on Huh7 cells,and the change of Bcl-2 expression in Huh7 cells. METHODS: Human hepatocellular carcinoma cells Huh7 were used. Cell viability was analyzed by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The expressions of Gli-1 and Bcl-2 family members were detected by RT-PCR and Western blot. Apoptosis was detected by Flow cytometry using propidium iodide,measured by Hoechst 33258 staining using Advanced Fluorescence Microscopy and caspase-3 enzymatic assay. Cell growth was analyzed after treatment with Gli-1 siRNA and 5-? uorouracil (5-Fu). RESULTS: Inhibition of Gli-1 mRNA in Huh7 cells through Gli-1 siRNA reduced cell viability. Gli-1 siRNA treatment also induced apoptosis by three criteria,increase in the sub-G1 cell cycle fraction,nuclear condensation,a morphologic change typical of apoptosis,and activation of caspase-3. Gli-1 siRNA was also able to down-regulate Bcl-2. However,Gli-1 siRNA resulted in no significant changes in Bcl-xl,Bax,Bad,and Bid. Furthermore,Gli-1 siRNA increased the cytotoxic effect of 5-Fu on Huh7 cell. CONCLUSION: Down-regulation of Bcl-2 plays an important role in apoptosis induced by Gli-1 siRNA in HCC cells. Combination Gli-1 siRNA with chemotherapeutic drug could represent a more promising strategy against HCC. The effects of the strategies need further investigation in vivo and may have potential clinical application. | Xi-Lin Chen Liang-Qi Cao Miao-Rong She Qian wang Xiao-Hui Huang Xin-Hui Fu | 2008 | World Journal of Gastroenterology2008，14，4： | 9 |
| 3 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 4 | Expression of reconstructive hF Ⅷ in the hrDNA by using hrDNA targeting vector显示文摘Our lab has constructed a new nonviral vec-tor—hrDNA targeting vector(pHrneo). pHrneo is a human derived vector that can target gene into human ribosomal DNA(hrDNA) locus. In this study, we inserted expression cassette of reconstructive hF Ⅷ (hFVIII-BDDAK39) to pHrneo to construct targeting vector: pHrneo-BDDAK39. Through electroporation of pHrneo-BDDAK39 into HT1080 cells, we identified the homologous recombinants by PCR and Southen blotting, and tested the expression of hFVIII- BDDAK39 in the hrDNA locus. The hFⅧ-BDDAK39 was successfully targeted into hrDNA locus of HT-1080 by pHrneo-BDDAK39, and the efficiency of site-specific inte-gration was 2.0×10?5. hFⅧ-BDDAK39 in hrDNA locus of HT-1080 is found to be able to express efficiently (32±5 ng·106 cells?1·24 h?1). Targeting vector pHrneo-BDDAK39 can find use in gene therapy for hemophilia. | LIU Xionghao LIU Mujun SHE Hua WEN Lu XUE Zhigang LIANG Desheng CAI Fang PAN Qian LONG Zhigao WU Lingqian DAI Heping XIA Kun XlA Jiahui | 2005 | Chinese Science Bulletin2005，50，19： | 5 |
| 5 | Effective and biocompatible antibacterial surfaces via facile synthesis and surface modification of peptide polymers显示文摘It is an urgent need to tackle drug-resistance microbial infections that are associated with implantable biomedical devices.Host defense peptide-mimicking polymers have been actively explored in recent years to fight against drug-resistant microbes.Our recent report on lithium hexamethyldisilazide-initiated superfast polymerization on amino acid N-carboxyanhydrides enables the quick synthesis of host defense peptide-mimicking peptide polymers.Here we reported a facile and cost-effective thermoplastic polyurethane(TPU)surface modification of peptide polymer(DLL:BLG=90:10)using plasma surface activation and substitution reaction between thiol and bromide groups.The peptide polymer-modified TPU surfaces exhibited board-spectrum antibacterial property as well as effective contact-killing ability in vitro.Furthermore,the peptide polymer-modified TPU surfaces showed excellent biocompatibility,displaying no hemolysis and cytotoxicity.In vivo study using methicillin-resistant Staphylococcus aureus(MRSA)for subcutaneous implantation infectious model showed that peptide polymer-modified TPU surfaces revealed obvious suppression of infection and great histocompatibility,compared to bare TPU surfaces.We further explored the antimicrobial mechanism of the peptide polymer-modified TPU surfaces,which revealed a surface contact-killing mechanism by disrupting the bacterial membrane.These results demonstrated great potential of the peptide-modified TPU surfaces for practical application to combat bacterial infections that are associated with implantable materials and devices. | Ziyi Lu Yueming Wu Zihao Cong Yuxin Qian Xue Wu Ning Shao Zhongqian Qiao Haodong Zhang Yunrui She Kang Chen Hengxue Xiang Bin Sun Qian Yu Yuan Yuan Haodong Lin Meifang Zhu Runhui Liu | 2021 | Bioactive Materials2021，6，12： | 5 |
| 6 | Magnetic resonance imaging of the extraocular muscles and corresponding cranial nerves in patients with special forms of strabismus显示文摘有技术进展的背景,磁性的回声成像(MRI ) 现在是足够敏感的检测从生活题目的 brainstem 和轨道产生的眼睛的马达神经的微妙的结构的畸形。这研究被设计描出在有有斜视的特殊形式的 29 个病人全部的 strabismus.Methods A 的特殊形式的病人的 MRI 特征经历了轨道并且 intracalvarium MRI。在 brainstem 的眼睛的马达神经的成像在用采用不变的获得(3D 节日) 的三维的快成像的飞机定序的 0.8 公里厚度图象被执行。到眼睛外面的肌肉( EOM )的神经, EOM 和他们的联系结缔组织被双阶段的卷在有眼睛外面的肌肉的先天的纤维变性的厚 planes.Results 病人展出了的 2.0 公里以内在tri平面的扫描与 T1 weighting 想象发育不全动眼( CN3 ),外展肌肉( CN6 ),软骨轮( CN4 )神经,和 EOM ;在 brainstem 和到侧面的权利的 CN3 的劣等的部门的一个额外的分支的 CN6 的发育不全是 Duane 的收回症候群的最普通然而并非唯一的演讲。CN6,美容(CN7 ) 和舌下神经(CN12 ) 神经的发育不全与 M (o) bius 症候群在病人被揭示。在双边的 synergistic 集中和分叉的稀罕诉讼中,到中间的权利的 CN3 的一个扩大分支和到劣等的权利的 CN3 的一个可疑分支双边地是 found.Conclusion MRI 能揭示眼睛的马达神经和他们的相应 EOM 的微妙的结构。这能在斜视的一些特殊形式关于致病提供珍贵信息。 | JIAO Yong-hong ZHAO Kan-xing WANG Zhen-chang QIAN Xue-han WU Xiao MAN Feng-yuan LU Wei SHE Hai-cheng | 2009 | Chinese Medical Journal2009，，24： | 4 |
| 7 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 8 | A histone H3K27me3 reader cooperates with a family of PHD finger-containing proteins to regulate flowering time in Arabidopsis显示文摘Trimethylated histone H3 lysine 27(H3 K27 me3)is a repressive histone marker that regulates a variety of developmental processes,including those that determine flowering time.However,relatively little is known about the mechanism of how H3 K27 me3 is recognized to regulate transcription.Here,we identified BAH domain-containing transcriptional regulator 1(BDT1)as an H3 K27 me3 reader.BDT1 is responsible for preventing flowering by suppressing the expression of flowering genes.Mutation of the H3 K27 me3 recognition sites in the BAH domain disrupted the binding of BDT1 to H3 K27 me3,leading to de-repression of H3 K27 me3-enriched flowering genes and an earlyflowering phenotype.We also found that BDT1 interacts with a family of PHD finger-containing proteins,which we named PHD1–6,and with CPL2,a Pol II carboxyl terminal domain(CTD)phosphatase responsible for transcriptional repression.Pull-down assays showed that the PHD finger-containing proteins can enhance the binding of BDT1 to the H3 K27 me3 peptide.Mutations in all of the PHD genes caused increased expression of flowering genes and an earlyflowering phenotype.This study suggests that the binding of BDT1 to the H3 K27 me3 peptide,which is enhanced by PHD proteins,is critical for preventing early flowering. | Feng Qian Qiu-Yuan Zhao Tie-Nan Zhang Yu-Lu Li Yin-Na Su Lin Li Jian-Hua Sui She Chen Xin-Jian He | 2021 | Journal of Integrative Plant Biology2021，63，4： | 2 |
| 9 | Synthe- sis, structures and properties of the first series of SrII- MII (M: Cu, Co, Ni and Zn) coordination polymers based on pyridine-2,5-dicarboxylic acid 显示文摘 | Chen Yanmei She Shixiong Gao Qian et ai | 2014 | CrystEng- Comm2014，16，6： | 1 |
| 10 | A fast refinement for adaptive gaussian chirplet decomposition 显示文摘 | Qinye Yin She Qian Aigang Feng | 2002 | IEEE Trans on Signal Processing2002，，50： | 1 |
| 11 | Overexpression of CaWRKY27 , a subgroup IIe WRKY transcription factor of Capsicum annuum , positively regulates tobacco resistance to Ralstonia solanacearum infection显示文摘 | Fengfeng Dang Yuna Wang Jianju She Yufen Lei Zhiqin Liu Thomas Eulgem Yan Lai Jing Lin Lu Yu Dan Lei Deyi Guan Xia Li Qian Yuan Shuilin He | 2014 | Physiol Plantarum2014，，3： | 1 |
| 12 | The preparation of nano-sulfur/MWCNTs and its electrochemical performance显示文摘 | Chen Jia-jia Jia Xin She Qiu-jie Wang Chong Zhang Qian Zheng Ming-sen Dong Quan-feng | 2010 | Electrochimica Acta2010，，27： | 1 |
| 13 | Advancement of chimeric antigen receptor-natural killer cells targeting hepatocellular carcinoma显示文摘With the advance of genome engineering technology,chimeric antigen receptors(CARs)-based immunotherapy has become an emerging therapeutic strategy for tumors.Although initially designed for T cells in tumor immunotherapy,CARs have been exploited to modify the function of natural killer(NK)cells against a variety of tumors,including hepatocellular carcinoma(HCC).CAR-NK cells have the potential to sufficiently kill tumor antigen-expressing HCC cells,independent of major histocompatibility complex matching or prior priming.In this review,we summarize the recent advances in genetic engineering of CAR-NK cells against HCC and discuss the current challenges and prospects of CAR-NK cells as a revolutionary cellular immunotherapy against HCC. | Kai Dai Yin Wu Sha She Qian Zhang | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 1 |
| 14 | Regulation of Neuronal Survival Factor MEF2D by Chaperone-Mediated Autophagy显示文摘 | Qian Yang Hua She Marla Gearing | 2009 | Science2009，323，： | 1 |
| 15 | TNFα inhibitor C87 sensitizes EGFRvⅢ transfected glioblastoma cells to gefitinib by a concurrent blockade of TNFα signaling显示文摘Objective: More than half of human glioblastomas show EGFR gene amplification and mutation, but EGFR inhibitors have not been effective in treating EGFR-positive glioblastoma patients.The mechanism behind this type of primary resistance is not well understood.The aim of this study was to investigate gefitinib resistance in glioblastoma, and explore ways to circumvent this significant clinical problem.Methods: MTT method was used to test the cell viability after EGFR-positive glioblastoma cells were treated with indicated drugs;real-time quantitative PCR method was included to detect the TNFα mRNA levels in glioma tissues and cell lines.ELISA was introduced to measure the TNFα protein levels in cell culture supernatant of glioblastoma cells treated with gefitinib.Western blot was used to detect the activity change of intracellular kinases in drug-treated glioblastoma cells.Two mouse xenograft tumor models were carried out to evaluate the in vivo effects of a combination of EGFR and TNFα inhibitors.Results: We found that glioblastoma resistance to gefitinib may be mediated by an adaptive pro-survival TNFα-JNK-Axl signaling axis, and that high TNFα levels in the glioblastoma microenvironment may further intensify primary resistance.A combination of the TNFα-specific small-molecule inhibitor C87 and gefitinib significantly enhanced the sensitivity of glioblastoma cells to gefitinib in vitro and in vivo.Conclusions: Our findings provide a possible explanation for the primary resistance of glioblastoma to EGFR inhibitors and suggest that dual blockade of TNFα and EGFR may be a viable therapeutic strategy for the treatment of patients with chemotherapy-refractory advanced glioblastoma. | Li Ma Chunhua She Qian Shi Qiang Yin Xinxin Ji Yongrong Wang Yulong Fan Xinyao Kong Peng Li Zengfeng Sun Xiaohui Zhang Zhen Zhang Jian Wang Tong Wang Yuanfu Xu Wenliang Li | 2019 | Cancer Biology & Medicine2019，16，3： | 1 |
| 16 | GRINDING RESIDUAL STRESS OF CEMENTED CARBIDE显示文摘Grinding residual stress in the surface layer of WC-6 Wt—%Co hard alloy was measured by means of X-ray diffraction. The effects of various grinding parameters and treatment processes on the stress were studied. By means of electrolytic etching, the stress distribution along the depths beneath the surface was measured. The relationship between the stress and the service life of the alloy is discussed. | Qian, Chongliang Wu, Enxi Lu, Haibo Central South University of Technology. Changsha 410083. China Chen, Ruikuan She, Zhenhui Wu, Chunhua Zhenzhou Cemented Carbide Industry Company. Zhenzhou 412000. China | 1993 | 中国有色金属学会会刊:英文版1993，3，1： | 0 |
| 17 | Photocatalyst-controlled and visible light-enabled selective oxidation of pyridinium salts显示文摘This study proposes two different methods of photocatalytic-controlled and visible light-induced selective oxidation of pyridiniums with air as the terminal oxidant.The key to these transformations is to choose the appropriate light source and photocatalyst.Pyridiniums are successfully converted into pyrroles through oxygen-mediated cycloaddition,proton-coupled electron transfer(PCET),pyridine ring opening,and recyclization.The other route is that pyridiniums selectively form 4-carbonyl pyridines through free radical rearrangement/aerobic oxidation under the catalysis of cobalt(Ⅱ). | Xiang-Jun Peng Hai-Ping He Qian Liu Kun She Bao-Qi Zhang Heng-Shan Wang Hai-Tao Tang Ying-Ming Pan | 2021 | Science China Chemistry2021，64，5： | 0 |
| 18 | Dynamical Changes of the Serum Nitric Oxide(NO) Concentrations after Subarachnoid Hemorrhage(SAlH) and the Effects of Acanthopanax Senticosus显示文摘Objective. To explore the dynamical changes of the serum NO concentrations after SAH and the effects of acanthopanax senti cosus. Background. No, as a vascul ar regulat i on factor, Plays an important role on cerebral blood circulation .High intention has been paid to the rclationaship betveen No and cerebral vasospasm following SAH. Methods. The serum NO concentrat,ons of simple SAH group and acanthopanax senticosus--treated group were dynamically measured in the 2nd, 4th and 6th day after onset. Results. The serum NO concentrations of simple SAH group and acanthopanax scnticosus-treated group in the 4th and 6th day after onset were obviously lower than those of control group(P<0.01,P<0.05).The serum NO concentrations of the two groups reached their minimum in the 4th day after onset and then went up gradually in the 6th day. The content of the red blood cell in the cerebrospinal tiui of the simple SAH group was significamily contrary related to the Serum N0 concentration in the 4 th day (r=-0. 69. P< 0. 01). Discussion. The Sources , Synthesis, functious of No , the relationship between No and SAl and the effects of acanthopanax Senticoaus were discussed. Conclusion. The serum NO concentrations of the patients after SAH decrease and that may be involvea in the mechanism of cerebral vasospasm (CVS). Acanthopanax senticosus can increase the serum NO concentrations. | She Zheng Ming Qian Hong Fa | 2000 | 中国临床神经科学2000，8，z1： | 0 |
| 19 | Fabrication of Ce-ReS_(2)by Molten Salt for Electrochemical Hydrogen Evolution显示文摘Renewable and economical generation of hydrogen via electrochemical methods shows great potential in addressing the energy crisis.In this study,an emerging molten salt method was adopted for the synthesis of a cerium-modifi ed rhenium disulfi de nanosheet for electrical hydrogen evolution reactions.The prepared 1%Ce-doped rhenium disulfi de(ReS_(2))sample showed promoted hydrogen evolution performance in both acid and alkaline electrolytes compared to bare ReS_(2).Generating of abundant defects in ReS_(2)exposed more reaction active sites.Moreover,adding cerium accelerated the hydrogen evolution dynamics.Hopefully,this work will off er new insight into developing ReS_(2)-based electrocatalysts for hydrogen evolution reactions. | Ran Chen Minghai Ma Yi Luo Liping Qian Shunli Wan Shengyou Xu Xinsong She | 2022 | Transactions of Tianjin University2022，28，6： | 0 |
| 20 | Power Dependence of the Recombination Processes in the In_(x)Ga_(1-x)As/GaAs Single Quantum Well显示文摘We have measured the power dependence of the photoluminesence spectra from a set of strained In_(x)Ga_(1-x)As/GaAs single quantum wells.The result shows that the excitation power has important effect on the carrier recombination processes.When the power increases from 0.5 to 14mW,the photoluminescence from the barrier becomes more intense than that from the well and the trapping efficiency decreases.At high excitation level,the ratio of the radiative recombination rate to the nonradiative recombination rate of the barrier increases ten times than that at lower excitation level,while it only doubles for the well. | QIAN Shixiong WU Jianyao YUAN Shu LI Yufen Thorwald G.Andersson CHEN Zonggui PENG Wenji SHE Weilong YU Zhenxin | 1991 | Chinese Physics Letters1991，8，8： | 0 |
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