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| 1 | Clinicopathologic characteristics and prognosis of gastroenteropancreatic neuroendocrine neoplasms: a multicenter study in South China显示文摘Background: Gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs) are a heterogeneous group of rare tumors. Many issues in terms of epidemiologic features, pathogenesis, and treatment of GEP-NENs are still under discussion. Our study aimed to analyze the clinicopathologic characteristics and prognosis of Chinese patients with GEP-NENs.Methods: Complete clinicopathologic data and survival information of 1183 patients with GEP-NENs treated between 2005 and 2015 were collected from five medical centers in Guangdong Province, China. Patient survival was estimated using the Kaplan–Meier method and analyzed using the log-rank test; prognostic factors were analyzed using the Cox proportional hazards model.Results: The most common tumor location was the rectum(37.4%), followed by the pancreas(28.1%), stomach(20.7%), small intestine(7.2%), appendix(3.4%), and colon(3.3%). After initial definitive diagnosis, 1016(85.9%) patients underwent surgery. The 1-, 3-, and 5-year overall survival(OS) rates for the entire cohort were 87.9%, 78.5%, and 72.8%, respectively. The 3-year OS rates of patients with G1, G2, and G3 tumors were 93.1%, 82.7%, and 43.1%, respectively(P < 0.001). The 3-year OS rates of patients with stage I, II, III, and IV tumors were 96.0%, 87.3%, 64.0%, and 46.8%, respectively(P < 0.001). Patients with distant metastasis who underwent palliative surgery had a longer survival than those who did not(P = 0.003). Similar survival benefits of palliative surgery were observed in patients with neuroendocrine tumor(P y, M category, and sur= 0.031) or neuroendocrine carcinoma(P gery were found to be independent prog= 0.046). In multivariate analysis, age, grade, N categornostic factors.Conclusions: Patients with GEP-NENs who are women, younger than 50 years old, have smaller tumor size, have lower tumor grade, have lower T/N/M category, and who undergo surgery can have potentially longer survival time. Our data showed that surgery can improve the prognosis of GEP-NEN patients with distant metastasis. However, randomized controlled trials need to be conducted to establish the optimal criteria for selecting patients to undergo surgery. | Cheng Fang Wei Wang Yu Zhang Xingyu Feng Jian Sun Yujie Zeng Ye Chen Yong Li Minhu Chen Zhiwei Zhou Jie Chen | 2017 | Chinese Journal of Cancer2017，36，10： | 23 |
| 2 | Hardware Design and Test of a Gear-Shifting Control System of a Multi-gear Transmission for Electric Vehicles显示文摘The performance of electric vehicles is affected by the shift quality of multi-gear transmission.The realization of dual-target tracking control requires the transmission control unit(TCU)to accurately measure and process the input signals of the gear-shifting control system and precisely control the drive motor torque and the position of shift motors.An electric-vehicle-dedicated TCU was designed to meet the above design requirements.Its function modules included a single-chip control circuit,shift position signal sampling circuit,signal conditioning circuit of the rotational speed and angle,controller area network communication circuit,and shift motor drive circuit.A hardware-in-the-loop simulation test system showed that the TCU design scheme met measurement accuracy requirements and coordinated the actions of the shift actuator and motor control unit to achieve fast and smooth shifting before the road test.The power interruption time of the shifting process was within 350 ms.The reliability of the TCU design was further verified in a 150,000-km vehicle road test. | Feng Tian Liqi Sui Yuanfan Zeng Bo Li Xingyue Zhou Lijun Wang Hongxu Chen | 2019 | Automotive Innovation2019，2，3： | 3 |
| 3 | First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment显示文摘We report the first results on ^(76)Ge neutrinoless double beta decay from stage one of the China dark-matter experiment(CDEX).A p-type point-contact high-purity germanium detector with a mass of 994 g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304 kg d has been analyzed over a wide spectral band from 500 keV to 3 MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039 MeV energy range. The half-life of ^(76)Ge neutrinoless double beta decay derived based on this result is T^(0ν)1/2>6.4×10^(22) yr(90% C.L.). An upper limit on the effective Majorana-neutrino mass of 5.0 eV has been achieved. | Li Wang Qian Yue KeJun Kang JianPing Cheng YuanJing Li TszKing Henry Wong ShinTed Lin JianPing Chang JingHan Chen QingHao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He QingJu He JinWei Hu HanXiong Huang TengRui Huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li XueQian Li YuLan Li FongKay Lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao Wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu WeiBin Zhu ZhongHua Zhu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，7： | 3 |
| 4 | GRU-Based Fault Diagnosis Method for Ball Mill显示文摘Recently, the fault diagnosis of the ball mill mostly depends on the experience of workers, which brings about a lot of uncertainty for fault diagnosis. In addition, the cost of labor is getting higher, so that the research of ball mill fault diagnosis based on machine learning has become increasingly valuable. The current fault diagnosis methods are mostly judging based on instantaneous data, which makes it difficult to reflect the ball mill indicators and the occurrence of time-related correlation(such as hysteresis effect). This paper presents a ball mill fault diagnosis method based on Gate Recursion Unit(GRU),which analyzes the fault data in the form of time series and compares with other common methods such as neural network, Autoencoder and Long Short-Term Memory(LSTM). After comparison,it is concluded that the fault diagnosis method based on GRU ball mill has the lowest error rate as 4.85%. | QU Xingyu ZENG Peng LI Junpeng | 2018 | Instrumentation2018，5，4： | 2 |
| 5 | Mendelian randomization study to investigate the causal relationship between plasma homocysteine and chronic obstructive pulmonary disease显示文摘BACKGROUND:Several observational studies have shown an association between homocysteine(Hcy)levels and chronic obstructive pulmonary disease(COPD),but causal relationships are not clear.Our study aimed to explore the causal relationship between plasma Hcy and COPD by two-sample Mendelian randomization(MR).METHODS:A two-sample MR study was performed to infer the causal link.Genetically predicted plasma Hcy was selected as an instrumental variable(Ⅳ)from published genome-wide association study(GWAS)meta-analyses.COPD with different etiologies was extracted as outcome variables from other GWAS meta-analyses.The main MR analysis was performed using the inversevariance weighted(IVW)method.Additional analyses were further performed using Cochran’s Q-test and MR-Egger regression to evaluate the heterogeneity or horizontal pleiotropy of our findings.RESULTS:MR analysis showed no significant association between plasma Hcy and COPD.The results of the groups were consistent with the sensitivity analysis and repeated analysis,without heterogeneity or horizontal pleiotropy.The IVW results showed COPD hospital admissions(odds ratio[OR]1.06,95%confidence interval[CI]0.91-1.24,P=0.42),asthma/COPD(OR 0.97,95%CI0.89-1.06,P=0.55),COPD-related chronic infection(OR 1.50,95%CI 0.57-3.99,P=0.41),COPDI asthma/interstitial lung disease(ILD)-related pneumonia or pneumonia-derived septicemia(OR 0.93,95%CI 0.86-1.02,P=0.13),and COPD-related respiratory insufficiency(OR 1.00,95%CI 0.7-1.44,P=0.99).CONCLUSION:There is no direct causal relationship between plasma Hcy and COPD in our study.As Hcy is known to have deleterious effects on endothelial function and vascular homeostasis,further studies are needed to investigate whether additional factors mediate the association between Hcy and COPD. | Yanlan Hu Ping Tan Juntao Wang Jun Zeng Quan Li Shijiao Yan Wenjie Hao Lanfen He Xingyue Song Caihong Zhang Chuanzhu Lyu | 2023 | World Journal of Emergency Medicine2023，14，5： | 0 |
| 6 | Simplified quantitative analysis method and its application in the insitu synthesized copper-based azide chips显示文摘Copper-based azide(Cu(N_(3))2 or CuN_(3),CA)chips synthesized by in-situ azide reaction and utilized in miniaturized explosive systems has become a hot research topic in recent years.However,the advantages of in-situ synthesis method,including small size and low dosage,bring about difficulties in quantitative analysis and differences in ignition capabilities of CA chips.The aim of present work is to develop a simplified quantitative analysis method for accurate and safe analysis of components in CA chips to evaluate and investigate the corresponding ignition ability.In this work,Cu(N_(3))2 and CuN_(3)components in CA chips were separated through dissolution and distillation by utilizing the difference in solubility and corresponding content was obtained by measuring N_(3)-concentration through spectrophotometry.The spectrophotometry method was optimized by studying influencing factors and the recovery rate of different separation methods was studied,ensuring the accuracy and reproducibility of test results.The optimized method is linear in range from 1.0-25.0 mg/L,with a correlation coefficient R^(2)=0.9998,which meets the requirements of CA chips with a milligram-level content test.Compared with the existing ICP method,component analysis results of CA chips obtained by spectrophotometry are closer to real component content in samples and have satisfactory accuracy.Moreover,as its application in miniaturized explosive systems,the ignition ability of CA chips with different component contents for direct ink writing CL-20 and the corresponding mechanism was studied.This study provided a basis and idea for the design and performance evaluation of CA chips in miniaturized explosive systems. | Jie Ren Yunfeng Li Mingyu Li Xingyu Wu Jiabao Wang Qingxuan Zeng | 2024 | Defence Technology(防务技术)2024，32，2： | 0 |
| 7 | Highly efficient twin-field quantum key distribution with neural networks显示文摘Quantum key distribution(QKD)allows two legitimate parties,Alice and Bob,to share a series of random bits that are secured by the laws of quantum mechanics.As a remarkable theoretical progress towards longer distances. | Jingyang LIU Qingqing JIANG Huajian DING Xiao MA Mingshuo SUN Jiaxin XU Chun-Hui ZHANG Shipeng XIE Jian LI Guigen ZENG Xingyu ZHOU Qin WANG | 2023 | Science China(Information Sciences)2023，66，8： | 0 |
| 8 | Chiral nanoporous networks featuring various chiral vertices from an achiral molecule on Ag(100)显示文摘Chiral nanoporous nanoarchitectures exhibit potential applications in various fields including chiral separation,sensing and catalysis.Two-dimensional(2D)supramolecular chemistry offers novel methods to build chiral nanoporous networks from achiral molecules.Herein,we report a series of chiral nanoporous networks built by an achiral precursor molecule via a stepwise annealing strategy on Ag(100).The nanoporous network morphologies and structural details are characterized by high-resolution scanning tunneling microscopy(STM).It is revealed that all vertices within networks are chiral.These chiral vertices are either dimeric,trimeric,or tetrameric.The connection of these chiral vertices gives rise to diverse chiral nanopores with varying shapes and sizes.A strict chirality correlation between nanopores and their vertices is determined.Specifically,enantiomeric vertices of one-pair nanopore enantiomers are always in identical type but opposite handedness.This work serves as a model to investigate the influence of vertex chirality on nanopore chirality of a supramolecular matrix.The attained chiral nanopores could potentially be utilized as templates for surface reaction,chiral recognition,etc.The mirror-symmetric silver adatoms clusters dictated by chiral nanopore are discerned. | Dong Han Tao Wang Jianmin Huang Xingyu Li Zhiwen Zeng Junfa Zhu | 2022 | Nano Research2022，15，4： | 0 |
| 9 | Research on ABAC Access Control Based on Big Data Platform显示文摘In the environment of big data,the traditional access control lacks effective and flexible access mechanism.Based on attribute access control,this paper proposes a HBMC-ABAC big data access control framework.It solves the problems of difficult authority change,complex management,over-authorization and lack of authorization in big data environment.At the same time,binary mapping codes are proposed to solve the problem of low efficiency of policy retrieval in traditional ABAC.Through experimental analysis,the results show that our proposed HBMC-ABAC model can meet the current large and complex environment of big data. | Kun Yang Xuanxu Jin Xingyu Zeng | 2021 | Journal of Cyber Security2021，3，4： | 0 |
| 10 | ICMPTend: Internet Control Message Protocol Covert Tunnel Attack Intent Detector显示文摘The Internet Control Message Protocol(ICMP)covert tunnel refers to a network attack that encapsulates malicious data in the data part of the ICMP protocol for transmission.Its concealment is stronger and it is not easy to be discovered.Most detection methods are detecting the existence of channels instead of clarifying specific attack intentions.In this paper,we propose an ICMP covert tunnel attack intent detection framework ICMPTend,which includes five steps:data collection,feature dictionary construction,data preprocessing,model construction,and attack intent prediction.ICMPTend can detect a variety of attack intentions,such as shell attacks,sensitive directory access,communication protocol traffic theft,filling tunnel reserved words,and other common network attacks.We extract features from five types of attack intent found in ICMP channels.We build a multi-dimensional dictionary of malicious features,including shell attacks,sensitive directory access,communication protocol traffic theft,filling tunnel reserved words,and other common network attack keywords.For the high-dimensional and independent characteristics of ICMP traffic,we use a support vector machine(SVM)as a multi-class classifier.The experimental results show that the average accuracy of ICMPTend is 92%,training ICMPTend only takes 55 s,and the prediction time is only 2 s,which can effectively identify the attack intention of ICMP. | Tengfei Tu Wei Yin Hua Zhang Xingyu Zeng Xiaoxiang Deng Yuchen Zhou Xu Liu | 2022 | Computers, Materials & Continua2022，，5： | 0 |
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