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| 1 | GS6, A Member of the GRAS Gene Family,Negatively Regulates Grain Size in Rice显示文摘Grain size is an important yield related trait in rice.Intensive arti cial selection for grain size during domestication is evidenced by the larger grains of most of today’s cultivars compared with their wild relatives.However,the molecular genetic control of rice grain size is still not well characterized.Here,we report the identi cation and cloning of Grain Size 6(GS6),which plays an important role in reducing grain size in rice.A premature stop at the t348 position in the coding sequence(CDS)of GS6 increased grain width and weight signi cantly.Alignment of the CDS regions of GS6 in 90 rice materials revealed three GS6alleles.Most japonica varieties(95%)harbor the Type I haplotype,and 62.9%of indica varieties harbor the Type II haplotype.Association analysis revealed that the Type I haplotype tends to increase the width and weight of grains more than either of the Type II or Type III haplotypes.Further investigation of genetic diversity and the evolutionary mechanisms of GS6showed that the GS6gene was strongly selected in japonica cultivars.In addition,a'ggc'repeat region identi ed in the region that encodes the GRAS domain of GS6 played an important historic role in the domestication of grain size in rice.Knowledge of the function of GS6might aid efforts to elucidate the molecular mechanisms that control grain development and evolution in rice plants,and could facilitate the genetic improvement of rice yield. | Lianjun Sun Xiaojiao Li Yongcai Fu Zuofeng Zhu Lubin Tan Fengxia Liu Xianyou Sun Xuewen Sun Chuanqing Sun | 2013 | Journal of Integrative Plant Biology2013，55，10： | 44 |
| 2 | Coking wastewater treatment for industrial reuse purpose: Combining biological processes with ultrafiltration, nanofiltration and reverse osmosis显示文摘A full-scale plant using anaerobic, anoxic and oxic processes (A1/A2/O), along with a pilot-scale membrane bioreactor (MBR), nanofiltration (NF) and reverse osmosis (RO) integrated system developed by Shanghai Baosteel Chemical Co. Ltd., was investigated to treat coking wastewater for industrial reuse over a period of one year. The removals reached 82.5% (COD), 89.6% (BOD), 99.8% (ammonium nitrogen), 99.9% (phenol), 44.6% (total cyanide (T-CN)), 99.7% (thiocyanide (SCN-)) and 8.9% (fluoride), during the A1/A2/O biological treatment stage, and all parameters were further reduced by over 96.0%, except for fluoride (86.4%), in the final discharge effluent from the currently operating plant. The pilot-scale MBR process reduced the turbidity to less than 0.65 NTU, and most of the toxic organic compounds were degraded or intercepted by the A1/A2/O followed MBR processes. In addition, parameters including COD, T-CN, total nitrogen, fluoride, chloride ion, hardness and conductivity were significantly reduced by the NF-RO system to a level suitable for industrial reuse, with a total water production ratio of 70.7%. However, the concentrates from the NF and RO units were highly polluted and should be disposed of properly or further treated before being discharged. | Xuewen Jin Enchao Li Shuguang Lu Zhaofu Qiu Qian Sui | 2013 | Journal of Environmental Sciences2013，25，8： | 38 |
| 3 | Leaching of vanadium from stone coal with sulfuric acid显示文摘The effects of roasting, mass ratio of H2SO4 to stone coal, leaching temperature, liquid-to-solid ratio, grinding fineness of stone coal, and two-stage counter-current leaching on the vanadium leaching ratio were studied. The results show that the vanadium leaching ratio of roasted stone coal through two-stage counter-current leaching can reach 65.1% at the mass ratio of H2SO4 to stone coal of 20%, leaching temperature of 95°C, leaching time of 30 h, liquid-to-solid ratio of 1.1 mL-g-1, and grinding fineness of 0.1 mm, which can serve as an experimental basis for the production of vanadium from stone coal. | WANG Mingyu XIAO Liansheng LI Qinggang WANG Xuewen XIANG Xiaoyan | 2009 | Rare Metals2009，28，1： | 26 |
| 4 | The Hardy Rubber Tree Genome Provides Insights into the Evolution of Polyisoprene Biosynthesis显示文摘Eucommia ulmoides,也叫的强壮的橡胶树,是一棵经济地重要的树;然而,它的染色体顺序的缺乏 ?限制基本生物研究和这植物种的应用研究。这里,我们在场它的 1.2-Gb 染色体的一个高质量的集会(支架 N50 ?=? 1.88 Mb ) 与至少 26 ? 为 E 的 723 预言的基因。ulmoides,顺序 Garryales 的首先定序的染色体,它用联合定序的 Illumina 的综合策略被获得,定序的 PacBio,和印射的 BioNano。作为到 lamiids 和 campanulids 的姐妹 taxon, E。ulmoides 经历了三倍由核心 eudicots 而是没有进一步整个染色体的复制分享了的一个古老的染色体 ? 在最后 1.25 亿年里。E。ulmoides 为涉及压力回答和第二等的代谢物的生合成的多重基因展出高表达式层次或基因数字扩大,它可以说明它的可观的环境适应性。与橡胶树(Hevea brasiliensis ) 相对照,它生产 cis 聚异式戊二我烯, E。ulmoides 演变综合经由 farnesyl diphosphate synthases (FPS ) 的长链的 trans 聚异式戊二我烯。而且, FPS 和橡胶延伸 factor/small 橡胶粒子蛋白质基因家庭从 H 独立地被扩展。brasiliensis 系。这些结果提供新卓见进 E. 的生物学 ? ulmoides 和聚异式戊二我烯生合成的起源。 | Ta-na Wuyun Lin Wang Huimin Liu Xuewen Wang Liangsheng Zhang Jeffrey L. Bennetzen Tiezhu Li Lirong Yang Panfeng Liu Lanying Du Lu Wang Mengzhen Huang Jun Qing Iili Zhu Wenquan Bao Hongguo Li Qingxin Du Jingle Zhu Hong Yang Shuguang Yang Hui Liu Hui Yue Jiang Hu Suoliang Yu Yu Tian Fan Liang Jingjing Hu Depeng Wang Ruiwen Gao Dejun Li Hongyan Du | 2018 | Molecular Plant2018，11，3： | 24 |
| 5 | Stage-progressive distribution pattern of the Lungmachi black graptolitic shales from Guizhou to Chongqing, Central China显示文摘The Lungmachi Formation is widely distributed in Guizhou, Chongqing and the adjacent area. It is important for the study of Silurian biostratigraphy and shale-gas investigation. Based on those biostratigraphically well-studied sections from Guiyang to Huayingshan, we reveal the stage-progressive distribution pattern of the Lungmachi black shales. The distribution of the Lungmachi black shales in the studying area can be subdivided into four geographic belts from the south to the north,reflecting the joint effect of regional and global environmental changes. The graptolite depth zonation model was adopted herein to infer the water depth of major graptolite assemblages from the black shales. The changes in the water depth indicate two major stages. The first stage is named the transgressive distribution stage which ranged from the Persculptograptus persculptus Biozone(LM1, upper Hirnantian) to the Coronograptus cyphus Biozone(LM5, upper Rhuddanian), an interval mostly controlled by global sea-level rise. The second stage, ranging from the Demirastrites triangulatus Biozone(LM6, lower Aeronian) to the Spirograptus guerichi Biozone(LM9, lower Telychian), is named the regressive shrinking stage, during which the black shales were gradually replaced by mixed-facies or carbonate sediments from the south to the north, representing the effects of the persistent uplifting of the Central Guizhou Oldland. | CHEN Xu FAN JunXuan WANG WenHui WANG HongYan NIE HaiKuan SHI XueWen WEN ZhiDong CHEN DongYang LI WenJie | 2017 | Science China Earth Sciences2017，60，6： | 23 |
| 6 | Survival of transplanted neurotrophin-3 expressing human neural stem cells and motor function in a rat model of spinal cord injury显示文摘<正>BACKGROUND:Many methods have been attempted to repair nerves following spinal cord injury, including peripheral nerve transplantation,Schwann cell transplantation,olfactory ensheathing cell transplantation,and embryonic neural tissue transplantation.However,there is a need for improved outcomes. OBJECTIVE:To investigate the repair feasibility for rat spinal cord injury using human neural stem cells(hNSCs) genetically modified by lentivirus to express neurotrophin-3. DESIGN,TIME AND SETTING:In vitro cell biological experiment and in vivo randomized,controlled, genetic engineering experiment were performed at the Third Military Medical University of Chinese PLA and First People's Hospital of Yibin,China from March 2006 to December 2007. MATERIALS:A total of 64 adult,female,Wistar rats were used for the in vivo study.Of them,48 rats were used to establish models of spinal cord hemisection,and were subsequently equally and randomly assigned to model,genetically modified hNSC,and normal hNSC groups.The remaining 16 rats served as normal controls. METHODS:hNSCs were in vitro genetically modified by lentivirus to secrete both green fluorescence protein and neurotrophin-3.Neurotrophin-3 expression was measured by Western blot. Genetically modified hNSC or normal hNSC suspension(5×10~5) was injected into the rat spinal cord following T_(10) spinal cord hemisection.A total of 5μL Dulbecco's-modified Eagle's medium was infused into the rat spinal cord in the model group.Transgene expression and survival of transplanted hNSCs were determined by immunohistochemistry.Motor function was evaluated using the Basso,Beattie,and Bresnahan(BBB) scale. MAIN OUTCOME MEASURES:The following parameters were measured:expression of neurotrophin-3 produced by genetically modified hNSCs,transgene expression and survival of hNSCs in rats,motor function in rats. RESULTS:hNSCs were successfully genetically modified by lentivirus to stably express neurotrophin-3.The transplanted hNSCs primarily gathered at,or around,the injection site two weeks following transplantation,and gradually migrated towards the surrounding tissue. Transplanted hNSCs were observed 7.0-8.0 mm away from the injection site.In addition,hNSCs were observed 10 weeks after transplantation.At week 4,BBB locomotor scores were significantly greater in the genetically modified hNSC and normal hNSC groups,compared with the model group (P<0.05),and scores were significantly greater in the genetically modified hNSC group compared with the normal hNSC group(P<0.05). CONCLUSION:hNSCs were genetically modified with lentivirus to stably secrete neurotrophin-3. hNSCs improved motor function recovery in rats following spinal cord injury. | Peiqiang Cai Guangyun Sun Peishu Cai Martin Oudega Rui Xiao Xuewen Wang Wei Li Yunbing Shu Cheng Cai Haihao Yang Xuebing Shan Wuhua Luo | 2009 | Neural Regeneration Research2009，4，7： | 18 |
| 7 | Mega-shoaling in carbonate platform of the Middle Triassic Leikoupo Formation,Sichuan Basin, Southwest China显示文摘Shoaling is a common type of sedimentation in the evolution of carbonate platform,and commonly has poor continuity.This paper presents a newly discovered and rare type of shoaling,i.e.,mega-shoaling in nearly basin scale,which is developed in the Middle Triassic Leikoupo Formation of the Sichuan Basin,southwest China.During the Leikoupo time,the studied Sichuan Basin experienced hot and dry climate conditions and developed a carbonate platform within a restricted epicontinental sea.In B sub-layer of the Lei-1-1 sub-member of the Leikoupo Formation a series of grainstones of shoal facies accumulated throughout almost the entire basin,thereby generating features associated with basin-scale mega-shoaling.By detailed core examination and microscopic observation of thin sections,it is shown that the lithology of this set of grainstones is dominated by doloarenite(calcarenite)followed by oolitic dolomite(limestone).In addition,it contains three types of sedimentary sequences characterized by upward-coarsening and upward-shallowing as the followings:restricted lagoon to platform interior beach;restricted lagoon to platform interior beach and to platform flat;and tidal flat to peritidal beach.Subsequently,a multicyclic stratigraphic division and correlation revealed that this set of grainstones can be well traced and compared horizontally,and is generally isochronous.In addition,a template for logging facies,established based on core calibrations and logging data,was employed to analyze the 235 wells in the basin.The results demonstrate the shoal grainstones to be 10–40 m thick with a15×104km2continuous distribution area.These findings indicate that the carbonate platform developed mega-shoals within a short period of time.The genesis of such a mega-shoaling was investigated by focusing on various shoaling conditions,such as paleo-tectonics,paleo-geomorphology,paleo-climate,sea-level changes,and palaeo-hydrodynamics.A specific combination of independent geological factors creates beneficial geomorphologic conditions for the mega-shoaling including a quiescent paleo-tectonic environment,relatively flat paleo-geomorphology and evaporites filling up and leveling off.In addition,a stably settling carbonate platform underwent sea-level fluctuations through swift transgressions and protracted regressions,which is not only conducive to continuous,multicyclic and superimposed vertical development of grain beaches but also beneficial for the horizontal migration,coalescence and superimposition of individual grain beaches.As a consequence,large-scale and continuously-distributed grain beach sedimentation emerges and mega-shoals develop. | TAN XiuCheng LI Ling LIU Hong CAO Jian WU XiaoQing ZHOU SuYan SHI XueWen | 2014 | Science China Earth Sciences2014，57，3： | 12 |
| 8 | Research on Pressure Tactile Sensing Technology Based on Fiber Bragg Grating Array显示文摘一个压力触觉的传感器基于纤维布拉格栅栏(FBG ) ,数组在这篇论文,和它的有弹性的身体的数字模拟被介绍被有限元素软件(ANSYS ) 实现。根据模拟,纤维布拉格栅栏绳在灵活硅酮被植入认识到传感器制造过程,并且一个严峻的系统被造。一系列刻度测试经由高精确被做通用出版社机器。触觉的传感器数组察觉了外部压力,它被纤维栅栏解调仪器使解调,并且三尺寸的图画被规划视觉上显示位置和尺寸。同时,传感器的一个动态接触实验为模仿在未知环境遇到另外的目标的机器人被进行。试验性的结果证明传感器有好线性,重覆性,并且有动态反应的好效果,并且它的压力敏感是 0.03 nm/N。另外,传感器也有反电磁的干扰的优点,好灵活性,简单结构,低等等花费,它被期望以后在便携人工的皮肤被过去常。 | Jinxue SONG Qi JIANG Yuanyang HUANG Yibin LI Yuxi JIA Xuewen RONG Rui SONG Hongbin LIU | 2015 | Photonic Sensors2015，5，3： | 8 |
| 9 | Combined genomic, transcriptomic, and metabolomic an alyses provide in sights into chayote (Sechium edule) evolution and fruit development显示文摘Chayote(Sechium edule)is an agricultural crop in the Cucurbitaceae family that is rich in bioactive components.To enhance genetic research on chayote,we used Nanopore third-generation sequencing combined with Hi-C data to assemble a draft chayote genome.A chromosome-level assembly anchored on 14 chromosomes(N50 contig and scaffold sizes of 8.40 and 46.56 Mb,respectively)estimated the genome size as 606.42 Mb,which is large for the Cucurbitaceae,with 65.94%(401.08 Mb)ofthe genome comprising repetitive sequences;28,237 protein-coding genes were predicted.Comparative genome analysis indicated that chayote and snake gourd diverged from sponge gourd and that a whole-genome duplication(WGD)event occurred in chayote at 25±4 Mya.Transcriptional and metabolic analysis revealed genes involved in fruit texture,pigment,fl avor,fl avonoids,antioxidants,and plant hormones during chayote fruit development.The analysis of the genome,transcriptome,and metabolome provides insights into chayote evolution and lays the groundwork for future research on fruit and tuber development and genetic improvements in chayote. | Anzhen Fu Qing Wang Jianlou Mu Lili Ma Changlong Wen Xiaoyan Zhao Lipu Gao Jian Li Kai Shi Yunxiang Wang Xuechuan Zhang Xuewen Zhang Fengling Wang Donald Grierson Jinhua Zuo | 2021 | Horticulture Research2021，8，1： | 6 |
| 10 | Adaptive Proportional-Derivative Sliding Mode Control Law With Improved Transient Performance for Underactuated Overhead Crane Systems显示文摘In this paper, an adaptive proportional-derivative sliding mode control(APD-SMC) law, is proposed for 2D underactuated overhead crane systems. The proposed controller has the advantages of simple structure, easy to implement of PD control, strong robustness of SMC with respect to external disturbances and uncertain system parameters, and adaptation for unknown system dynamics associated with the feedforward parts. In the proposed APD-SMC law, the PD control part is used to stabilize the controlled system, the SMC part is used to compensate the external disturbances and system uncertainties,and the adaptive control part is utilized to estimate the unknown system parameters. The coupling behavior between the trolley movement and the payload swing is enhanced and, therefore, the transient performance of the proposed controller is improved.The Lyapunov techniques and the La Salle's invariance theorem are employed in to support the theoretical derivations. Experimental results are provided to validate the superior performance of the proposed control law. | Menghua Zhang Xin Ma Rui Song Xuewen Rong Guohui Tian Xincheng Tian Yibin Li | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，3： | 5 |
| 11 | Dry Heat Treatment Reduces the Occurrence of Cladosporium cucumerinum, Ascochyta citrullina, and Colletotrichum orbiculare on the Surface and Interior of Cucumber Seeds显示文摘Dry heat treatment has been identifie as a method for disinfecting seed-borne pathogens in vegetable seeds. This study demonstrated that three seed-borne pathogens of cucumber(Cladosporium cucumerinum that causes scabs, Ascochyta citrullina that results in gummy stem blight,and Colletotrichum orbiculare that induces anthracnose) could be effectively eradicated from cucumber seeds by dry heat treatment. In vitro growth of these three pathogens was inhibited by dry heat treatment at 70 °C for 40 min. These pathogens were inactivated after exposing infected seeds to 70 °C dry heat for at least 90 min. Seed infection was significant y reduced by exposing the seeds to 70 °C dry heat for at least 40 min. Seed moisture content and germination were slightly reduced after 70 °C heat treatment for 40–120 min. Seed vigor remained at a high level after dry heat treatment at 70 °C for 90 min. In conclusion, 70 °C dry heat treatment for 90 min was determined to be the optimal method for eradication of C. cucumerinum, Didymella bryoniae, and C. orbiculare from cucumber seeds. | SHI Yanxia MENG Shanshan XIE Xuewen CHAI Ali LI Baoju | 2016 | Horticultural Plant Journal2016，2，1： | 5 |
| 12 | MoS2 nanorods with inner caves through synchronous encapsulation of sulfur for high performance Li–S cathodes显示文摘Lithium–sulfur(Li–S)batteries have become one of the most promising candidates for next-generation batteries owing to their high specific capacity,low cost,and environment-friendliness.Many efforts have been made to mitigate the'shuttle effect'through physical adsorption and chemical bonding.MoS2 has been proposed as a cathode material to provide effective anchoring sites for lithium polysulfides(Li PSs),but is still limited by its layer structure.Herein,we designed novel MoS2 nanorods with inner caves based on our previous work,and performed synchronous encapsulation of sulfur during the synthesis process.The outer MoS2 tubular shells physically inhibit the outward diffusion of polysulfide species while the inner particles chemically anchor the polysulfides to prevent shuttling.As the cathode matrix in Li–S batteries,the electrochemical results deliver a high initial discharge capacity of 1213 mAhg^-1 for sulfur at 0.1 C.After cycling at 1 C for 300 cycles,the cells exhibit a capacity decay of only 0.076%per cycle and high average coulombic efficiency over 95%.The tubular MoS2 structure is an innovative and appealing design,which could be regarded as a prospective substrate for the improved performance of Li–S batteries. | Yikun Yi Zechen Liu Pu Yang Tao Wang Xuewen Zhao Hongyang Huang Yonghong Cheng Jinying Zhang Mingtao Li | 2020 | Journal of Energy Chemistry2020，29，6： | 5 |
| 13 | Efficient full-path optical calculation of scalar and vector diffraction using the Bluestein method显示文摘Efficient calculation of the light diffraction in free space is of great significance for tracing electromagnetic field propagation and predicting the performance of optical systems such as microscopy,photolithography,and manipulation.However,existing calculation methods suffer from low computational efficiency and poor flexibility.Here,we present a fast and flexible calculation method for computing scalar and vector diffraction in the corresponding optical regimes using the Bluestein method.The computation time can be substantially reduced to the sub-second level,which is 105 faster than that achieved by the direct integration approach(~hours level)and 102 faster than that achieved by the fast Fourier transform method(~minutes level).The high efficiency facilitates the ultrafast evaluation of light propagation in diverse optical systems.Furthermore,the region of interest and the sampling numbers can be arbitrarily chosen,endowing the proposed method with superior flexibility.Based on these results,full-path calculation of a complex optical system is readily demonstrated and verified by experimental results,laying a foundation for real-time light field analysis for realistic optical implementation such as imaging,laser processing,and optical manipulation. | Yanlei Hu Zhongyu Wang Xuewen Wang Shengyun Ji Chenchu Zhang Jiawen Li Wulin Zhu Dong Wu Jiaru Chu | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 14 | Synthesis of Osthole Derivatives with Grignard Reagents and Their Larvicidal Activities on Mosquitoes显示文摘osthole 的结构被修改了对蚊子改进它的 larvicidal 活动。有 Grignard 试剂的 osthole 衍生物的新有效合成被开发了,它作为倡导者采用 CuI 和 LiCl 并且盖住大量底层负担得起相应产品在对好收益(多达 83%) 温和。简历活动评估证明几个产品比 osthole 展出了更好的活动。 | Ming Liu Yang Liu Xuewen Hua Changchun Wu Sha Zhou Baolei Wang Zhengming Li | 2015 | Chinese Journal of Chemistry2015，33，12： | 4 |
| 15 | Facile synthesis of nanoceria by a molten hydroxide method and its photocatalytic properties显示文摘Ceria nanoparticles were facilely synthesized by a molten NaOH-KOH hydroxide flux method with the precursor of Ce(NO3)3·6H2O under different conditions in alumina crucibles or Teflon-lined stainless steel autoclave.The XRD patterns and TEM images show that both the crystal and particle sizes of synthesized nanoceria are around 10 nm.XPS results reveal that the nanoceria obtained in alumina crucible has a Ce3+fraction of 17.1%which is higher than that of ceria synthesized in the Teflon vessel,the FTIR spectra of nanoceria prepared in alumina crucible show a stronger intensity of O-H stretching mode.UV-DRS and PL spectra results show that the nanoceria synthesized in alumina crucible with a calculated band gap of 2.9 eV has a wider responding light wavelength and a lower photogene rated electron-hole recombination rate,due to a higher concentration of oxygen vacancies(Ce^3+%).The photocatalytic results show that the degradation ratio and rate of the Rhodamine B(RhB)solution with the nanoceria synthesized in alumina crucible are 98.39%and 0.02919 min-1,both of which are larger than those of the ceria obtained from Teflon vessel.This method proves to be a simple and scalable way to synthesize nanoceria with rich oxygen vacancies and high photocatalytic activity. | Xuewen Xia Yuanpei Lan Junqi Li Chaoyi Chen Benjun Xu Xian Luo Xisong Mao | 2020 | Journal of Rare Earths2020，38，9： | 4 |
| 16 | A Trot and Flying Trot Control Method for Quadruped Robot Based on Optimal Foot Force Distribution显示文摘In order to enhance the dynamic motion capability of the bionic quadruped robot,a flying trot gait control method based on full-scale virtual model and optimal plantar force distribution is proposed.A stable flying trot gait is accomplished by mapping the robot torso motion to the foot trajectory.The force distribution calculated by the torso virtual model is converted into a quadratic optimization problem and solved in real time by the open source library Gurobi.The transition between the trot gait and the flying trot gait is achieved by coordinating leg motion phases.The results of the dynamic simulation verify that the proposed method can realize the 3D stable flying trot gait.Compared against the trot gait,the flying trot gait can improve the speed of the quadruped robot.Combine the trot gait and the flying trot gait,the quadruped robot can move efficiently and adapt to complex terrains. | Teng Chen Xiaobo Sun Ze Xu Yibin Li Xuewen Rong Lelai Zhou | 2019 | Journal of Bionic Engineering2019，16，4： | 4 |
| 17 | Pulse labeling and long-term tracing of newborn neurons n the adult subgranular zone显示文摘在过去的十年的研究证明了那个成年大脑生产增殖并且区分到集成到存在电路的新生的神经原的神经祖先房间。然而,详细说明了区别过程和最新产生的神经原的内在的机制由于为把神经祖先房间和新生的神经原标记并且操作的可得到的方法的限制大部分是未知的。在这研究,我们设计了一紧控制了, noninvasive 系统基于 Cre/loxP 再结合到完成在 vivo 的长期的跟踪和成年神经原的基因操作。在这个系统, tamoxifen 可诱导的 recombinase, CreERT2,被 doublecortin 的基于用绳子拖的平底渡船的倡导者驾驶(DCX,新生的神经原的一个标记) 。由带着记者老鼠穿过这根 Cre 线,我们发现在有牙齿的回转(DG ) 的新生的神经原能由黄的导致 tamoxifen 的表示是有选择地标记脉搏的荧光灯蛋白质(YFP ) 。YFP 积极的神经原被 coimmunostaining 与房间识别类型特定的标记并且由记录的 electrophysiological 描绘了。而且,这些神经原的迁居的分析证明这些标记的神经原的多数移居了到小粒房间层的内部部分。而且,新生的小粒神经原的内部分子的层的脊骨生长拿一个动态模式转换 U 形状,与在外部分子的层的楔形的变化相对照。我们的转基因的工具提供一个有效方法有选择地在成年老鼠 DG 把新生的神经原标记并且操作。 | Xuewen Cheng Yang Li Ying Huang Xiaoyan Feng Guoping Feng Zhi-Qi Xiong | 2011 | Cell Research2011，21，2： | 4 |
| 18 | Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects显示文摘Both opioids and nonsteroidal anti-inflammatory drugs(NSAIDS)produce deleterious side effects and fail to provide sustained relief in patients with chronic inflammatory pain.Peripheral neuroinflammation(PN)is critical for initiation and development of inflammatory pain.A better understanding of molecular mechanisms underlying PN would facilitate the discovery of new analgesic targets and the development of new therapeutics.Emerging evidence suggests that peripheral sensory neurons are not only responders to painful stimuli,but are also actively engaged in inflammation and immunity,whereas the intrinsic regulatory mechanism is poorly understood.Here we report the expression of proton-selective ion channel Hv1 in peripheral sensory neurons in rodents and humans,which was previously shown as selectively expressed in microglia in mammalian central nervous system.Neuronal Hv1 was up-regulated by PN or depolarizing stimulation,which in turn aggravates inflammation and nociception.Inhibiting neuronal Hv1 genetically or by a newly discovered selective inhibitor YHV98-4 reduced intracellular alkalization and ROS production in inflammatory pain,mitigated the imbalance in downstream SHP-1-pAKT signaling,and also diminished pro-inflammatory chemokine release to alleviate nociception and morphine-induced hyperalgesia and tolerance.Thus,our data reveal neuronal Hv1 as a novel target in analgesia strategy and managing opioids-related side effects. | Qiansen Zhang Yimin Ren Yiqing Mo Peipei Guo Ping Liao Yuncheng Luo Jie Mu Zhuo Chen Yang Zhang Ya Li Linghui Yang Daqing Liao Jie Fu Juwen Shen Wei Huang Xuewen Xu Yanyan Guo Lianghe Mei Yunxia Zuo Jin Liu Huaiyu Yang Ruotian Jiang | 2022 | Cell Research2022，32，5： | 3 |
| 19 | Design, Synthesis and Herbicidal Activity of Novel Sulfonylureas Containing Tetrahydrophthalimide Substructure显示文摘 | HUA Xuewen ZHOU Sha CHEN Minggui ZHANG Dongkai LIU Ming LIU Jingbo WU Changchun LIU Yang LI Yonghong LI Zhengming | 2016 | Chemical Research in Chinese Universities2016，32，3： | 3 |
| 20 | Insight into selective removal of copper from high-concentration nickel solutions with XPS and DFT:New technique to prepare 5N-nickel with chelating resin显示文摘An efficient and profitable separation process was proposed to prepare 5N(the purity of the metal solution reaches 99.999%) high-purity nickel from 3N nickel-solutions using Purolite S984. The adsorption performance of this superior resin, especially its selectivity for metal ions,was explored quantitatively. The maximum adsorption capacity for copper was 2.286 mmol/g calculated by the Langmuir model, which was twice as large as that for nickel. In the binary systems, the adsorption capacity for nickel was decreased by 45%, indicating direct competition for the active sites. The infinite separation factor for copper versus nickel exceeded 300, revealing the feasibility of preparing5N-level high-purity nickel solutions, which was further verified using the 800 BV(bed volume) effluent in the column dynamic process.According to the cost–benefit analysis, purification contributed to a profit of approximately 60,000 USD per cycle, and the investment return period was less than 1/3 years. Density functional theory analysis confirmed that four nitrogen atoms would be involved in the coordination complex and thus a structure involving two five-membered rings could be achieved. The X-ray photoelectron spectra confirmed the involvement of nitrogen atoms,implying a coordination ratio of approximately 1:1. | Xuewen Tao Fuqiang Liu Zhiping Bai Dongyang Wei Xiaopeng Zhang Junfei Wang Jie Gao Xiaowen Sun Baohua Li Chenghui Li Aimin Li | 2016 | Journal of Environmental Sciences2016，28，10： | 3 |
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