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| 1 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 2 | Relationship between phenotypes of cell-function differentiation and pathobiological behavior of gastric carcinomas显示文摘AIM To reveal the correlation between thefunctional differentiation phenotypes of gastriccarcinoma cells and the invasion and metastasisby a new way of cell-function classification.METHODS Surgically resected specimens of361 gastric carcinomas (GC) were investigatedwith enzyme-, mucin-, and tumor-related markerimmunohistochemist ry. According to thedirection of cell-function differentiation,stomach carcinomas were divided into fivefunctionally differentiated types.iation type (AFDT): there were 82 (22.7%)patients including 76 (92.7%) aged 45 years.Sixty-nine (84.1%) cases belonged to theintestinal type. Thirty-eight (46.3%) expressedCD44v6 and 9 (13.6%) of 66 male patientsdeveloped liver metastasis. The 5-year survivalrate of patients in this group (58.5%) was higherMucin secreting function differentiation type(MSFDT): 54 (15%) cases. Fifty-three (98.1%)tumors had penetrated the serosa, 12 (22.2%)expressed ER and 22 (40.7%) expressedCD44v6. The postoperative 5-year survival ratefunction differentiation type (AMPFDT): therewere 180 (49.9%) cases, including 31 (17.2%)aged yanger than 45 years. The tumor was morecommon in women (62, 34.4%,) and expressedmore frequently estrogen receptors (ER) ( 129,81.7%) than other types (P<0.01). Ovarymetastasis was found in 12 (19.4%) out of 62female subjects. The patients with this type GChad the lowest 5-year survival rate (24.7%)differentiation type (SFDT): 13 (3.6%) cases.Nine (69.2%) tumors of this type derived fromAPUD system, the other 4 (30.7%) were ofdifferent histological differentiation. Sixty percent of the patients survived at least five years.(8.9%) cases. Nineteen (59.4%) cases hadlymph node metastases but no one with liver orovary metastasis. The 5-year survival rate was28.1%.CONCLUSION This new cell-functionclassification of GC is helpful in indicating thecharacteristics of invasion and metastasis of GCwith different cell-function differentiationphenotypes. Further study is needed to disclosethe correlation between the cell-functionaldifferentiation phenotypes and the relevantgenotypes and the biological behavior of gastriccarcinoma. | Yan Xin Xiao Ling Li Yan Ping Wang Su Min Zhang Hua Chuan Zheng Dong Ying Wu Yin Chang Zhang The Fourth Laboratory of Cancer Institute, China Medical University, Shenyang 110001, Liaoning Province, China | 2001 | World Journal of Gastroenterology2001，7，1： | 38 |
| 3 | Toll-like receptor 4/nuclear factor-kappa B signaling detected in brain after early subarachnoid hemorrhage显示文摘背景发炎和免疫在 subarachnoid 出血(SAH ) 以后在早大脑损害的致病起一个重要作用。原子 factor-kappa B (NF-KB ) 为发炎和免疫调整许多基因必需品并且被像使用费的受体(TLR ) 激活。这研究试图检测在早 SAH 以后在老鼠大脑发信号的像使用费的受体 4/nuclear factor-kappa B (TLR4/NF-KB ) 的表示。老鼠被将斩首的方法和他们的大脑在血的单个注射以后在 0, 2, 4, 6, 12, 24 和 48 个小时被移开进 prechiasmatic 水塘, TLR4 的 mRNA 表示被 immunohistochemistry 并且西方的弄污被 Taqman 即时 RT-PCR,和蛋白质表示测量。肿瘤坏死 factor-alpha (TNF-) 的 NF-KB 活动和集中, interleukin-lbeta (IL-) 和 intedeukin-6 (IL-6 ) 被试金(ELISA ).Results TaqMan 即时 RT-PCR 并且西方的弄污识别了的连接酶的 immunosorbent 测量在在 mRNA 和蛋白质的 TLR4 表示的一个 biphasic 变化:一座起始的山峰(2-6 小时) 和持续举起(12-48 小时) 。染色的 Immunohistochemical 在 glial 房间和脉管的内皮细胞层主要显示出 TLR4-1ike 免疫反应的可诱导的表示。在象 NF-KB-regulated proinflammatory cytokines (TNF- , IL-1 和 IL-6 ) 的生产一样的 NF-KB 子单元 p65 的激活的一个类似的 biphasic 变化被 ELISA 检测。结论这些数据建议试验性的 SAH 导致在早大脑损害发信号的 TLR4 表示和 NF-KB 的重要起来规定。发信号的 TLR4/NF-KB 的激活可以在 SAH 以后调整煽动性的回答。 | MA Chun-xiao YIN Wei-ning CAI Bo-wen WU Jian WANG Jun-yi HE Min SUN Hong DING Jun-li YOU Chao | 2009 | Chinese Medical Journal2009，，13： | 33 |
| 4 | Fermented soybean meal improves the growth performance, nutrient digestibility, and microbial flora in piglets显示文摘In order to increase nutritive values of soybean meal(SBM), 3 species of microbes were used to ferment SBM. Through a 3 x 3 orthogonal design and parameter measurements of soybean peptide and antinutritional factor contents in the fermented soybean meal(FSBM), it was estimated that the best microbial proportion of Bacillus subtilis, Hansenula anomala and Lactobacillus casei was 2:1:2 for SBM fermentation(P < 0.05). The further piglet feeding experiment showed that 10% FSBM substitute for SBM had no significant effect on growth performance of suckling piglets(d 7-28)(P> 0.05). However, newlyweaned piglets(d 28-38) fed 10% FSBM and different levels of plasma protein obtained higher average daily gain(ADG) and feed conversion ratio(FCR), compared with those without FSBM but with 6% plasma protein(P < 0.05). Piglets(d 38-68) fed diets supplemented with FSBM and soybean protein concentrate(SBPC) at 3.75% and 7.5% respectively increased nutrient digestibility,fecal enzyme activity and lactic acid bacteria counts, and decreased fecal Escherichia coli counts(P < 0.05), compared with the control. These data indicated that FSBM had positive effects on nutrient digestibility and fecal microflora for piglets. | Lin Yuan Juan Chang Qingqiang Yin Min Lu Yuanran Di Ping Wang Zhixiang Wang Erzhu Wang Fushan Lu | 2017 | Animal Nutrition2017，，1： | 31 |
| 5 | Standards of Ecological Compensation for Traditional Ecoagriculture:Taking Rice-Fish System in Hani Terrace as an Example显示文摘Traditional eco-agriculture provides many ecosystem services which are important for the local environment, especially in mountain areas. In order to encourage the farmers to engage in eco-agriculture,it is necessary to establish an eco-compensation mechanism for them. As the compensation standard is one of key issues in establishing eco-compensation mechanism, this paper calculated the standard based on the farmers' willingness to accept(WTA) and the input-output analysis of eco-compensation. We took the traditional rice-fish eco-agriculture as the research object, conducting field surveys in Hani Terrace of Honghe County. Through the questionnaires in 2011, we obtained the farmers' willingness to accept government compensation and market compensation. Then, the research evaluated the output of eco-compensation, the economic value of rice-fish paddy ecosystem services. Finally, under different market compensation standards, we compared the input and output of government compensation. The results show that, in 2011 the government should to pay farmers 7462 yuan·ha–1·a-1to meet their willingness, but the output(ecological benefit) was only 7393 yuan·ha–1·a-1. However, when the rice price increases 1 yuan·kg-1 because of the limited use of chemicals in the next year, the government just has to pay farmers 4062 yuan·ha–1·a-1 and the surplus will be 3331 yuan·ha–1·a-1. | LIU Mou-cheng XIONG Yin YUAN Zheng MIN Qing-wen SUN Ye-hong Anthony M.Fuller | 2014 | Journal of Mountain Science2014，11，4： | 33 |
| 6 | Methionine-dependence and combination chemotherapy on human gastric cancer cells in vitro显示文摘AIM: To elucidate whether human primary gastric cancer and gastric mucosa epithelial calls in vitro can grow normally in a rnethionine (Met) depleted environment, i.e.Met-dependence, and whether Met-depleting status can enhance the killing effect of chemotherapy on gastric cancer cells.lMETHODS: Fresh human gastric cancer and mucosal tissueswere managed to form monocellular suspensions, whichwere then cultured in the Met-free but homocysteine-containing ( MetHcy+ ) medium, with differentchemotherapeutic drugs. The proliferation of the cells wasexamined by cell counter, flow cytometry (FCM) andmicrocytotoxicity assay (MTT).RESULTS: The growth of human primary gastric cancer cellsin Met Hcy+ was suppressed, manifested by the decrease oftotal cell counts [1.46±0.42 ( x 109@L-1) in Met-Hcy+ vs .64±0.44 ( x l09@L-1) in Met+ Hcy, P<0.01], the decline inthe percentage of G0G1 phase cells (0.69±0.24 in Met-Hey+vs 0.80±0.18 in Met+ Hcy, P<0.01) and the increase of Scells(0.24±0.20inMet-Hcy+ vs 0.17 ± 0.16 in Met+ Hcy-, P< 0.01); however, gastric mucusal cells grew normally. IfMet-Hcy+ medium was used in combination withchemotherapeutic drugs, the number of surviving gastriccancer cells dropped significantly.CONCLUSION: Human primary gastric cancer cells in vitroare Met-dependent; however, gastric mucosal cells have notshown the same characteristica. Met- Hcy+ environment maystrengthen the killing effect of chemotherapy on humanprimary gastric cancer cells. | Wei-Xin Cao Jing-Min Ou Xu-Feng Fei,Department of Clinical Nutrition,Shanghai Institute of Digestive Surgery,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China Zheng-Gang Zhu Hao-Ran Yin Min Yan Yan-Zhen Lin,Department of Surgery,Shanghai Institute of Digestive Surgery,Ruijin Hospital,Shanghai Second Medical University,Shangha 200025,China | 2002 | World Journal of Gastroenterology2002，8，2： | 24 |
| 7 | Charlson comorbidity index helps predict the risk of mortality for patients with type 2 diabetic nephropathy显示文摘研究目的:探讨Charlson合并症指数(CCI)对2型糖尿病肾病死亡率的预测作用。研究方法:建立2型糖尿病肾病研究队列,根据CCI评分将患者合并症的严重程度分为三度:轻度(CCI1–2分)、中度(CCI 3–4分)、重度(CCI≥5分)。将影响死亡率的因素及按CCI分层后的组间差异指标进行Logistic回归分析及方差分析(ANOVA)。Kaplan-Meier生存曲线分析CCI指数对生存时间及死亡率的影响。重要结论:533例2型糖尿病肾病患者纳入研究。所有患者的CCI评分均大于1,44.7%(238/533)的患者死亡。患者的死亡率随CCI评分增加而增加,CCI 1–2分患者的死亡率为21.0%(50/238),CCI 3–4分患者的死亡率为56.7%(135/238),CCI≥5分患者的死亡率为22.3%(53/238)。Logistic回归分析显示CCI评分、血红蛋白和血浆白蛋白水平是患者死亡率的预测因子(P<0.05)。方差分析结果显示,与CCI评分相对较低的患者相比,CCI评分越高的患者其血红蛋白水平较低,而血清肌酐较高,死亡率也更高。Kaplan-Meier生存曲线显示CCI评分越高的患者生存时间越短。CCI评分是一种简单易行且实用的评估疾病合并症的方法,可用于预测2型糖尿病肾病患者的死亡率。关注2型糖尿病肾病患者的合并症将有利于早期、有效治疗及改善预后。 | You-qun HUANG Rong GOU Yong-shu DIAO Qing-hua YIN Wen-xing FAN Ya-ping LIANG Yi CHEN Min WU Li ZANG Ling LI Jing ZANG Lu CHENG Ping FU Fang LIU | 2014 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2014，15，1： | 23 |
| 8 | Application of bedside continuous blood purification in patients with multiple organ dysfunction syndromes显示文摘BACKGROUND:The complications of systemic inflammatory response syndrome(SIRS)include acute lung injury,acute kidney injury,shock,and multiple organ dysfunction syndrome(MODS).In recent years,how to clear inflammatory mediators has become a hot topic in critical care medicine.Researchers hypothesize that continuous blood purification(CBP) can effectively eliminate a variety of inflammatory mediators which participate in the occurrence of MODS and adjust the immune imbalance.This study aimed to observe the effects of CBP in MODS patients.METHODS:In this retrospective clinical study,a total of 38 MODS patients,18 males and 20 females,were enrolled.After conventional therapy,all the patients received CBP.Biochemistry,blood gas analysis,oxygenation index,mean arterial blood pressure(MAP),acute physiology and chronic health evaluation(APACHE) II scores were monitored.RESULTS:After CBP,the vital signs of patients were rapidly stable,and electrolyte disorders and acid-base imbalance were corrected.Renal function,blood gas,oxygenation index were all improved.MAP was increased,and APACHE II score was significantly decreased.All patients had good tolerance,stable hemodynamics,and no obvious adverse reaction on CBP compared with pre-CBP.CONCLUSION:CBP can effectively clean toxins,correct electrolyte acid-base balance,and improve systemic inflammatory response syndrome and the organ function of MODS patients. | Hai-bo Liu Min Zhang Jing-xiao Zhang Yong-jie Yin | 2012 | World Journal of Emergency Medicine2012，3，1： | 21 |
| 9 | Salt-responsive genes in rice revealed by cDNA microarray analysis显示文摘We used cDNA microarrays containing ~9,000 unigenes to identify 486 salt responsive expressed sequence tags (ESTs) (representing ~450 unigenes) in shoots of the highly salt-tolerant rice variety, Nona Bokra (Oryza sativa L. Ssp.Indica pv. Nona). Some of the genes identified in this study had previously been associated with salt stress. Howeverthe majority were novel, indicating that there is a great number of genes that are induced by salt exposure. Analysis of the salt stress expression profile data of Nona provided clues regarding some putative cellular and molecular processes that are undertaken by this tolerant rice variety in response to salt stress. Namely, we found that multiple transcription factors were induced during the initial salt response of shoots. Many genes whose encoded proteins are implicated in detoxification, protectant and transport were rapidly induced. Genes supporting photosynthesis were repressed and those supporting carbohydrate metabolism were altered. Commonality among the genes induced by salt exposure with those induced during senescence and biotic stress responses suggests that there are shared signaling pathways among these processes. We further compared the transcriptome changes of the salt-sensitive cultivar, IR28, with that of Nona rice. Many genes that are salt responsive in Nona were found to be differentially regulated in IR28. This study identified a large number of candidate functional genes that appear to be involved in salt tolerance and further examination of these genes may enable the molecular basis of salt tolerance to be elucidated. | Dai Yin CHAO Yong Hai LUO Min SHI Da LUO Hong Xuan LIN | 2005 | Cell Research2005，15，10： | 17 |
| 10 | An Empirical Study on Chinese City Network Pattern Based on Producer Services显示文摘Globalization and informatization have accelerated city networking process over the world, which makes research on city network a hot topic in the fields of urban geography and economic geography. With Chinese economic structure adjustment and city economic growth, producer services have begun to play an increasingly important role in city-region networking. This paper employs the methodology of world city network to analyze and explain the spatial development characteristics of China's urban network system based on the data of nationwide producer services enterprise network. The research result indicated that the distribution of producer services network has a positive effect on the development of Chinese city networks. City network connectivity is closely related to the significance of city in producer services development, and the former will gradually decline with the drop of the latter. Accordingly, the 64 cities can be divided into the national central cities, regional central cities, sub-regional central cities and local central cities in accordance with their position and role in the nationwide producer services network. It is concluded that high-grade cities with quality producer services dominate the pattern of Chinese city networks and there emerges three spatial agglomerations of producer services enterprises in Changjiang (Yangtze) River Delta, Zhujiang (Pearl) River Delta and Beijing-Tianjin-Tangshan Economical Region. Moreover, the distribution of different producer services industry varies from city to city, which also affects the characteristics of network development. | ZHEN Feng WANG Xia YIN Jun ZHANG Min | 2013 | Chinese Geographical Science2013，23，3： | 17 |
| 11 | Clinical application of subjective global assessment in Chinese patients with gastrointestinal cancer显示文摘AIM:To investigate the role of subjective global assessment(SGA) in nutritional assessment and outcome prediction of Chinese patients with gastro-intestinal cancer.METHODS:A total of 751 patients diagnosed with gastrointestinal cancer between August 2004 and August 2006 were enrolled in this study.Within 72 h after admission, SGA, anthropometric parameters, and laboratory tests were used to assess the nutritional status of each patient.The outcome variables including hospital stay, complications, and in-hospital medical expenditure were also obtained.RESULTS:Based on the results of SGA, 389(51.8%), 332(44.2%), and 30(4.0%) patients were classified into well nourished group(SGA-A), mildly to moderately malnourished group(SGA-B), and severely malnourished group(SGA-C), respectively.The prevalence of malnutrition classif ied by SGA, triceps skinfold thickness(TSF), mid-upper arm muscle circumference(MAMC), albumin(ALB), prealbumin(PA), and body mass index(BMI) was 48.2%, 39.4%, 37.7%, 31.3%, 21.7%, and 9.6%, respectively.In addition, ANOVA tests revealed significant differences in body mass index(BMI), TSF, PA, and ALB of patients in different SGA groups.The more severely malnourished the patient was, the lower the levels of BMI, TSF, PA, and ALB were(P < 0.05).χ2 tests showed a significant difference in SGA classif ication between patients receiving different types of treatment(surgery vs chemotherapy/radiotherapy).As the nutritional status classif ied by SGA deteriorated, the patients stayed longer in hospital and their medical expenditures increased significantly.Furthermore, multiple regression analysis showed that SGA and serum ALB could help predict the medical expenditures and hospital stay of patients undergoing surgery.The occurrence of complications increased in parallel with the increasing grade of SGA, and was the highest in the SGA-C group(23.3%) and the lowest in the SGA-A group(16.8%).CONCLUSION:SGA is a reliable assessment tool and helps to predict the hospital stay and medical expenditures of Chinese surgical gastrointestinal cancer patients. | Bei-Wen Wu Tao Yin Wei-Xin Cao Zhi-Dong Gu Xiao-Jin Wang Min Yan Bing-Ya Liu | 2009 | World Journal of Gastroenterology2009，15，28： | 16 |
| 12 | Metamorphism of the northern Liaoning Complex:Implications for the tectonic evolution of Neoarchean basement of the Eastern Block,North China Craton显示文摘As one of the areas where typical late Archean crust is exposed in the Eastern Block of the North China Craton,the northern Laioning Complex consists principally of tonalitic-trondhjemitic-granodioritic(TTG) gneisses,massive granitoids and supracrustal rocks.The supracrustal rocks,named the Qingyuan Group, consist of interbedded amphibolite,hornblende granulite,biotite granulite and B1F.Petrological evidence indicates that the amphibolites experienced the early prograde(M1),peak(M2) and post-peak(M3) metamorphism.The early prograde assemblage(M1) is preserved as mineral inclusions,represented by actinotite + hornblende + plagioclase + epidote + quartz + sphene,within garnet porphyroblasts.The peak assemblage(M2) is indicated by garnet + clinopyroxene + hornblende + plagioclase + quartz + ilmenite, which occur as major mineral phases in the rock.The post-peak assemblage(M3) is characterized by the garnet + quartz symplectite.The P—T pseudosections in the NCFMASHTO system constructed by using THERMOCALC define the P-T conditions of Ml,M2 and M3 at 490-550℃/<4.5 kbar,780-810℃/7.65- 8.40 kbar and 630-670℃/8.15-9.40 kbar,respectively.As a result,an anticlockwise P-T path involving isobaric cooling is inferred for the metamorphic evolution of the amphibolites.Such a P-T path suggests that the late Archean metamorphism of the northern Liaoning Complex was related to the intrusion and underplating of mantle-derived magmas.The underplating of voluminous mantle-derived magmas leading to metamorphism with an anticlockwise P-T path involving isobaric cooling may have occurred in continental magmatic arc regions,above hot spots driven by mantle plumes,or in continental rift environments. A mantle plume model is favored because this model can reasonably interpret many other geological features of late Archean basement rocks from the northern Liaoning Complex in the Eastern Block of the North China Craton as well as their anticlockwise P—T paths involving isobaric cooling. | Kam Kuen Wu Guochun Zhao Min Sun Changqing Yin Yanhong He Pui Yuk Tam | 2013 | Geoscience Frontiers2013，4，3： | 14 |
| 13 | Antioxidant and Anti-inflammatory Capacity of Ferulic Acid Released from Wheat Bran by Solid-state Fermentation of Aspergillus niger显示文摘Objective A strain of Aspergillus niger(A. niger), capable of releasing bound phenolic acids from wheat bran, was isolated. This strain was identified by gene sequence identification. The antioxidant and anti-inflammatory capacity of ferulic acid released from wheat bran by this A. niger strain(FA-WB) were evaluated. Methods Molecular identification techniques based on PCR analysis of specific genomic sequences were conducted; antioxidant ability was examined using oxygen radical absorbance capacity(ORAC), cellular antioxidant activity(CAA) assays, and erythrocyte hemolysis assays. RAW264.7 cells were used as a model to detect anti-inflammatory activity. Results The filamentous fungal isolate was identified to be A. niger. ORAC and CAA assay showed that FA-WB had better antioxidant activity than that of the ferulic acid standard. The erythrocyte hemolysis assay results suggested that FA-WB could attenuate AAPH-induced oxidative stress through inhibition of reactive oxy gen species(ROS) generation. FA-WB could significantly restore the AAPH-induced increase in intracellular antioxidant enzyme activities to normal levels as well as inhibit the intracellular malondialdehyde formation. TNF-?, IL-6, and NO levels indicated that FA-WB can inhibit the inflammation induced by lipopolysaccharide(LPS). Conclusion Ferulic acid released from wheat bran by a new strain of A. niger had good anti-inflammatory activity and better antioxidant ability than standard ferulic acid. | YIN Zhi Na WU Wen Jia SUN Chong Zhen LIU Hui Fan CHEN Wen Bo ZHAN Qi Ping LEI Zhuo Gui XIN Xuan MA Juan Juan YAO Kun MIN Tian ZHANG Meng Meng WU Hui | 2019 | Biomedical and Environmental Sciences2019，32，1： | 14 |
| 14 | ZmCOL3, a CCT gene represses flowering in maize by interfering with the circadian clock and activating expression of ZmCCT显示文摘Flowering time is a trait vital to the adaptation of flowering plants to different environments.Here, we report that CCT domain genes play an important role in flowering in maize(Zea mays L.).Among the 53 CCT family genes we identified in maize, 28 were located in flowering time quantitative trait locus regions and 15 were significantly associated with flowering time, based on candidate-gene association mapping analysis.Furthermore, a CCT gene named ZmCOL3 was shown to be a repressor of flowering.Overexpressing ZmCOL3 delayed flowering time by approximately 4 d, in either long-day or short-day conditions.The absence of one cytosine in the ZmCOL3 3'UTR and the presence of a 551 bp fragment in the promoter region are likely the causal polymorphisms contributing to the maize adaptation from tropical to temperate regions.We propose a modified model of the maize photoperiod pathway, wherein ZmCOL3 acts as an inhibitor of flowering either by transactivating transcription of ZmCCT, one of the key genes regulating maize flowering, or by interfering with the circadian clock. | Minliang Jin Xiangguo Liu Wei Jia Haijun Liu Wenqiang Li Yong Peng Yanfang Du Yuebin Wang Yuejia Yin Xuehai Zhang Qing Liu Min Deng Nan Li Xiyan Cui Dongyun Hao Jianbing Yan | 2018 | Journal of Integrative Plant Biology2018，60，6： | 14 |
| 15 | Cloning and characterization of a potato StAN11 gene involved in anthocyanin biosynthesis regulation显示文摘Anthocyanins are a class of products of plant secondary metabolism and are responsible for tubers color in potato.The biosynthesis of anthocyanins is a complex Researchbiological process,in which multiple genes are involved including structural genes and regulatory genes.In this study,StAN11,a WD40-repeat gene,was cloned from potato cultivar Chieftain(Solanum tuberosum L.).StAN11(HQ599506)contained no intron and its open reading frame(ORF)was 1,029 bp long,encoding a putative protein of 342 amino acids.In order to verify its role in anthocyanin biosynthesis,StAN11 was inserted behind the CaMV-35S promoter of pCMBIA1304 and the recombination vector was introduced into the potato cultivar Désirée plants by Agrobacterium-mediated transformation.The color of transgenic tuber skin was significantly deepened,compared to the wild-type control,which was highly consistent with the accumulation of anthocyanin and expression of StAN11 in transgenic lines tuber skin.Further analysis on the expression of Flavonone-3-hydroxylase(F3H),Dihydroflavonol reductase(DFR),Anthocyanidin synthase(ANS),and Flavonoid 3-O-glucosyl transferase(3GT)in transgenic plants revealed that only DFR was upregulated.This result suggested that StAN11 regulated anthocyanin biosynthesis in potato by controlling DFR expression and accumulation of anthocyanin could be increased through overexpression of StAN11 in the tubers with the genetic background of anthocyanin biosynthesis. | Wang Li Bing Wang Man Wang Min Chen Jing-Ming Yin Ghullam Murtaza Kaleri Rui-Jie Zhang Tie-Niu Zuo Xiong You Qing Yang | 2014 | Journal of Integrative Plant Biology2014，56，4： | 13 |
| 16 | Effect of various crop rotations on rice yield and nitrogen use efficiency in paddy–upland systems in southeastern China显示文摘To evaluate the effects of various rotation systems on rice grain yield and N use efficiency, a paddy–upland cropping experiment(2013–2016) was conducted in southeastern China. The experiment was designed using six different rice––winter crop rotations: rice–fallow(RF),rice–wheat(RW), rice–potato with rice straw mulch(RP), rice–green manure(Chinese milk vetch; RC–G), rice–oilseed rape(RO), and rice–green manure crop(oilseed rape with fresh straw incorporated into soil at flowering; RO–G) and three N rates, N0(0 kg N ha-1), N1(142.5 kg N ha-1), and N2(202.5 kg N ha-1). Average rice yields in the RF(5.93 t ha-1) rotation were significantly lower than those in the rotations with winter crops(7.20–7.48 t ha-1)under the N0 treatment, suggesting that incorporation of straw might be more effective for increasing soil N than winter fallow. The rice yield differences among the rotations varied by year with the N input. In general, the grain yields in the RP and RO–G rotations –were respectively 11.6–28.5% and 14.80–37.19% higher than those in the RF in plots with N applied. Increasing the N rate may have tended to minimize the average yield gap between the RF and the other rotations; the yield gaps were 18.55%, 4.14%, and 0.23% in N0, N1, and N2, respectively. However, the N recovery efficiency in the RF was significantly lower than that in other rotations, except for 2015 under both N1 and N2 rates, a finding that implies a large amount of chemical N loss. No significant differences in nitrogen agronomic efficiency(NAE) and physiological efficiency(NPE) were found between the rotations with legume(RC–G) and non–legume(RO and RW) winter crops, a result that may be due partly to straw incorporation. For this reason, we concluded that the return of straw could reduce differences in N use efficiency between rotations with and without legume crops. The degree of synchrony between the crop N demand and the N supply was evaluated by comparison of nitrogen balance degree(NBD) values. The NBD values in the RP and RW were significantly lower than those in the other rotations under both N1 and N2 rates. Thus,in view of the higher grain yield in the RP compared to the RW under the N1 rate, the RP rotation might be a promising practice with comparable grain yield and greater N use efficiency under reduced N input relative to the other rotations. The primary yield components of the RF and RP were identified as number of panicles m-2 and numbers of kernels panicle-1, respectively. The NAE and NPE were positively correlated with harvest index, possibly providing a useful indicator for evaluating N use efficiency. | Song Chen Shaowen Liu Xi Zheng Min Yin Guang Chu Chunmei Xu Jinxiang Yan Liping Chen Danying Wang Xiufu Zhang | 2018 | The Crop Journal2018，6，6： | 13 |
| 17 | Deposition of FeCoNiCrMn high entropy alloy(HEA) coating via cold spraying显示文摘High entropy alloys(HEAs) are of great interest in the community of materials science and engineering due to their unique phase structure. They are constructed with five or more principal alloying elements in equimolar or near-equimolar ratio. Therefore, HEAs can derive their performance from multiple principal elements rather than a single element. In this work, solid-state cold spraying(CS) was applied for the first time to produce FeCoNiCrMn HEA coating. The experimental results confirm that CS can be used to produce a thick HEA coating with low porosity. As a low-temperature deposition process, CS completely retained the HEA phase structure in the coating without any phase transformation. The characterization also reveals that the grains in the CSed HEA coating had experienced significant refinement as compared to those in the as-received HEA powder due the occurrence of dynamic recrystallization at the highly deformed interparticle region. Due to the increased dislocation density and grain boundaries,CSed HEA coating was much harder than the as-received powder. The tribological study shows that the CSed FeCoNiCrMn HEA coating resulted in lower wear rate than laser cladded HEA coatings. | Shuo Yin Wenya Li Bo Song Xingchen Yan Min Kuang Yaxin Xu Kui Wen Rocco Lupoi | 2019 | Journal of Materials Science & Technology2019，35，6： | 13 |
| 18 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 19 | Association of CYP3A polymorphisms with the pharmacokinetics of cyclosporine A in early post- renal transplant recipients in China显示文摘目的: 回顾地评估细胞色素 P450 3A (CYP3A ) 和 ATP 有约束力的盒子亚科 B 的协会成员 1 (ABCB1 ) 有用汉语的 cyclosporine A (CsA ) 的 pharmacokinetics 的基因多型性肾移植病人。 | Xiang-guang MENG Cheng-xian GUO Guo-qing FENG Ying-chun ZHAO Bo-ting ZHOU Jian-le HAN Xin CHEN Yong SHI Hong-yao SHI Ji-ye YIN Xiang-dong PENG Qi PEI Wei ZHANG Guo WANG Meng HE Min LIU Jing-ke YANG Hong-hao ZHOU | 2012 | Acta Pharmacologica Sinica2012，33，12： | 11 |
| 20 | Effects of lysedEnterococcus faecalis FK-23 on experimental allergic rhinitis in a murine model显示文摘In the current study,we sought to investigate whether lysed Enterococcus faecalis FK-23(LFK),a heat-killed probiotic preparation,attenuated eosinophil influx into the upper airway and had immunomodulatory activity in a murine allergic rhinitis model.Eighteen BALB/c mice were divided into three groups;the ovalbumin(OVA)-sensitized/challenged group,which received saline orally for 6 weeks(OVA group),the OVA-sensitized/challenged group,which received LFK orally for 6 weeks(LFK-fed group),and the non-sensitized group,which received saline for 6 weeks(saline control group).Nasal rubbing and sneezing were monitored during the study.After the final challenge,interleukin(IL)-4,interferon(IFN)-γ,and OVA-specific IgE levels in the sera and splenocyte culture supernatants were determined,eosinophilic infiltrate into the upper airway was quantified,and splenic CD4+CD25+ regulatory T cells(Tregs) were examined by flow cytometry.We found that nasal rubbing was significantly reduced in LFK-fed mice compared to the OVA group on d 27 and 35,and sneezing was significantly inhibited by LFK administration for 35 d.LFK-fed mice had significantly less eosinophil influx into the nasal mucosa than the OVA group.There were no significant differences between the LFK-fed group and OVA group in the serum and splenocyte culture supernatant levels of IL-4,IFN-γ,and OVA-specific IgE.Interestingly,the LFK-fed mice had a significantly greater percentage of splenic CD4+CD25+ Tregs than OVA group.Our results indicate that oral administration of LFK may alleviate nasal symptoms,reduce nasal eosinophilia,and increase the percentage of CD4+CD25+ Tregs in experimental allergic rhinitis. | Luping Zhu Takashi Shimada Ruoxi Chen Meiping Lu Qingzhao Zhang Wenmin Lu Min Yin Tadao Enomoto Lei Cheng | 2012 | The Journal of Biomedical Research2012，26，3： | 11 |
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