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| 1 | Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors显示文摘Multipotent 神经干细胞为房间治疗保持大诺言。到导致的 pluripotent 干细胞以及成熟神经原的成纤维细胞的 reprogramming 建议可能性没有首先建立 pluripotency,把一个严重地区分的体的房间变换成一个 multipotent 状态。这里,我们证明房间从中层导出的那 Sertoli 能直接被变换成拥有神经干细胞性质的一个 multipotent 状态。导致的神经干细胞(iNSCs ) 表示多重 NSC 特定的标记,展出类似于正常 NSC 的全球基因表示侧面,并且能够自强并且区分功能的神经原进神经胶质并且 electrophysiologically。为酷氨酸 hydroxylase (TH ) 积极的导出 iNSC 的神经原污点, γ -aminobutyric 酸,和胆碱 acetyltransferase。另外, iNSCs 能熬过并且产生跟随移植进有牙齿的回转的触处。iNSCs 的产生可以为疾病建模和再生药有重要含意。 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Libin Wang Wei Li Haijiang Zhang Xiao-Yang Zhao Lei Liu Ziwei Wang Changlong Guo Hua-Jun Wu Zhonghua Liu Liu Wang Shigang He Xiu-Jie Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，1： | 31 |
| 2 | CO_2 Emissions Embodied in China's Foreign Trade:An Investigation from the Perspective of Global Vertical Specialization显示文摘In light of the growth in vertically specialized in global trade,the present paper uses input-output tables from the World Input-Output Database to construct an environmental multiregional input-output model to calculate the CO_2 emissions embodied in China's international trade during 1995-2009.The advantage of this model lies in its incorporation of the reexported CO_2emissions component embodied in trade and its ability to differentiate domesticsourcedCO_2 emissions from foreign-sourced CO_2 emissions in trade.The results show that carbon emissions embodied in both China's exports and imports increased significantly during 1995-2009.One important reason for this is that the re-exported carbon emissions embodied in China's imported intermediate inputs increased substantially during this period.Our research reveals that accelerating the transformation of trade pattern and upgrading processing trade should be emphasized in the formulation of policy to prompt CO_2 emissions abatement in China. | Yuhuan Zhao Zhonghua Zhang Song Wang Shaojun Wang | 2014 | China & World Economy2014，22，4： | 21 |
| 3 | Evolution characters of water exchange abilities between Dongting Lake and Yangtze River显示文摘在 19512010 在东廷·莱克和长江主流由使用相关控制的地调查水文学数据驻扎,在到从不同时间规模的三座峡水库( TGR )的操作的二水身体和他们的反应之间的水交换能力的进化字符基于他们的水力的关系被分析。结果如下被显示出。第一在 7 月 9 月期间,到东廷·莱克的三个插头的补充能力更强壮,并且在 1 月三月,到长江的东廷·莱克的补充能力更强壮。第二,在东廷·莱克和长江之间的水交换系数上有一个明显的内部十的波浪。在 19511958 和 19591968,到东廷·莱克的三个插头的补充能力更强壮,但是在 20032010,到长江的东廷·莱克的补充能力被加强了。第三,三个插头的喷洒部门能力变弱,并且来自三个插头的东廷·莱克的水在三座峡水库的操作以后在典型的年里或在 TGR 的不同派遣模式下面减少。而且,来自四条河的东廷·莱克的水拿主导的位置,它显然提高东廷·莱克的补充能力到长江。第四如果在盆的流量变化的效果没被考虑,交换能力和交换的进化人物在规模通常与在他们之间的水交换数量的变化被改变的不同时间在东廷·莱克和长江之间处理,尽管影响水的因素交换在他们之间的能力是很复杂的。在河湖水交换能力和河湖水交换之间有同轴的生长或衰落关系的这些表演总计。 | OU Chaomin LI Jingbao ZHOU Yongqiang CHENG Weiyan YANG Yan ZHAO Zhonghua | 2014 | Journal of Geographical Sciences2014，24，4： | 19 |
| 4 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 5 | Organochlorine pesticides and polycyclic aromatic hydrocarbons in water and sediment of the Bosten Lake,Northwest China显示文摘We evaluated organic pollution in Bosten Lake, Xinjiang, China, by measuring the concentrations and distributions of organochlorine pesticides(OCPs) and polycyclic aromatic hydrocarbons(PAHs). Water and sediment samples were collected from 19 sites(B1–B19) in the lake for analysis. Our analytical results show that the concentrations of total OCPs in water ranges from 30.3 to 91.6 ng/L and the concentrations of PAHs ranges from undetectable(ND) to 368.7 ng/L. The concentrations of total OCPs in surface(i.e., lake bottom) sediment ranges from 6.9 to 16.7 ng/g and the concentrations of PAHs ranges from 25.2 to 491.0 ng/g. Hexachlorocyclohexanes(HCHs) and dichlorodiphenyltrichloroethanes(DDTs) account for large proportions of the OCPs. Low α- to γ-HCH ratios in both water and sediment samples indicate possible contributions from both industrial products and lindane. DDTs in water are probably from historical input, whereas DDTs in sediments are from both historical and recent inputs. Moreover, DDT products in both water and sediments were from multiple sources in the northwestern part of the lake(B11, B12, B13, and B14). Fugacity ratios for DDT isomers(p,p′-DDE and p,p′-DDT) at these sites were generally higher than equilibrium values. These results suggest that the input from the Kaidu River and diffusion of DDTs from the sediment to the water are responsible for DDT pollution in the water. Lower-molecular-weight PAHs, which originate primarily from wood and coal combustion and petroleum sources, represent the major fraction of the PAHs in both water and sediment samples. Our findings indicate that OCPs and PAHs in Bosten Lake can be attributed primarily to human activities. A risk assessment of OCPs and PAHs in water and sediment from Bosten Lake, however, suggests that concentrations are not yet high enough to cause adverse biological effects on the aquatic ecosystem. | SHEN Beibei WU Jinglu ZHAO Zhonghua | 2017 | Journal of Arid Land2017，9，2： | 12 |
| 6 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 7 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 8 | Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase1(LSD1/KDM1A)显示文摘Histone lysine specific demethylase 1(LSD1) has been recognized as an important modulator in post-translational process in epigenetics. Dysregulation of LSD1 has been implicated in the development of various cancers. Herein, we report the discovery of the hit compound 8 a(IC50=3.93 μmol/L) and further medicinal chemistry efforts, leading to the generation of compound 15 u(IC50=49 nmol/L, and Ki= 16 nmol/L), which inhibited LSD1 reversibly and competitively with H3 K4 me2, and was selective to LSD1 over MAO-A/B. Docking studies were performed to rationalize the potency ofcompound 15 u. Compound 15 u also showed strong antiproliferative activity against four leukemia cell lines(OCL-AML3, K562, THP-1 and U937) as well as the lymphoma cell line Raji with the IC50 values of 1.79, 1.30, 0.45, 1.22 and 1.40 μmol/L, respectively. In THP-1 cell line, 15 u significantly inhibited colony formation and caused remarkable morphological changes. Compound 15 u induced expression of CD86 and CD11 b in THP-1 cells, confirming its cellular activity and ability of inducing differentiation.The findings further indicate that targeting LSD1 is a promising strategy for AML treatment, the triazolefused pyrimidine derivatives are new scaffolds for the development of LSD1/KDM1 A inhibitors. | Zhonghua Li Lina Ding Zhongrui Li Zhizheng Wang Fengzhi Suo Dandan Shen Taoqian Zhao Xudong Sun Junwei Wang Ying Liu Liying Ma Bing Zhao Pengfei Geng Bin Yu Yichao Zheng Hongmin Liu | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 6 |
| 9 | Designing near-natural planting patterns for plantation forests in China显示文摘Background: China has a long tradition of managing planted forests. Different species of Populus, Eucalyptus, Larix, Cunninghamia and Pinus are planted to satisfy the local demand for wood products and provide ecological services at the same time. Evidence of the greater resilience of natural forests provides the motivation to develop asymmetric planting patterns, which is the focus of this study. We present a new method for designing plantation patterns that follow those observed in natural ecosystems and to maintain some regularity for operational convenience. Methods: Based on the uniform angle index, we analyzed the spatial structure of six natural forests in different regions of China. The uniform angle index describes the degree of spatial uniformity of the n nearest neighbors of a given reference tree. Accordingly, we identified all possible patterns of a neighborhood group within a regular planting pattern and developed a method to optimize planting point arrangements that contain some randomness as well as a minimum degree of regularity. Results:(1) There are 13 types of structural units in a regular planting, including seven random units, five even units and one cluster unit;(2) Five near-natural arrangements are presented with a minimum proportion of 50% of random units. These five arrangements represent a combination of regularity for operational convenience and asymmetry. Conclusions: The new planting patterns developed in this study are expected to increase the asymmetric competition and resilience of these important ecosystems. Some experimental plantings, based on our findings, have already been established, e.g., in Pinus tabulaeformis plantations in Tianshui, Gansu Province, and in a Populus deltoides plantation in Fangshan near Beijing. | Gongqiao Zhang Gangying Hui Yanbo Hu Zhonghua Zhao Xiuling Guan Klaus von Gadow Ganggang Zhang | 2019 | Forest Ecosystems2019，6，3： | 6 |
| 10 | Comparison of the distribution of the repetitive DNA sequences in three variants of Cucumis sativus reveals their phylogenetic relationships显示文摘有在拷贝数字或 / 并且顺序多型性的可变性的重复 DNA 序列能作为有用分子的标记被采用学习 phylogenetics 并且当在 situ 杂交(鱼) 与荧光结合了时,识别种类 / 染色体。Cucumis sativus 有三变体, Cucumis sativus L。var。sativus, Cucumis sativus L。var。hardwickii 和 Cucumis sativus L。var。xishuangbannesis。在这三变体之中的 phylogenetics 很好没用 cytological 里程碑被探索。这里,我们在黄瓜专注于高度重复的 DNA 序列的组织和分发,与栽培变种和野黄瓜之间的差别上的强调。在黄瓜和它的亲戚的 chromosomal karyotypes 的差异在我们的学习被检测。从而,有多探查鸡尾酒的三个集合的顺序的鱼(有染色体特定的 fosmid 的联合重复 DNA 作为探针克隆) 在一样的中期房间上被进行,它帮助了我们同时识别每野黄瓜 C 的 7 个中期染色体。sativus var。hardwickii。体的中期染色体的标准化 karyotype 被构造。我们也显示的数据在栽培变种黄瓜和 C 之间的关系。s。var。xishuangbannesis 比 C 的靠近。s。var。xishuangbannesis 和 C。s。var。hardwickii。 | Xin Zhao Jingyuan Lu Zhonghua Zhang Jiajin Hu Sanwen Huang Weiwei Jin | 2011 | Journal of Genetics and Genomics2011，38，1： | 5 |
| 11 | Effect of Yiqiyangyin recipe on heparanase and nephrin in rats with adriamycin-induced nephropathy显示文摘OBJECTIVE: To discuss the mechanism of Yiqiyangyin recipe in rats with adriamycin (ADR)-induced nephropathy. METHODS: We randomly divided 30 Sprague-Dawley rats into 5 groups: control, model, glucocorticoid, Chinese herb, and Chinese herb plus glucocorticoid groups. The 24-h urine volume was collected on days 7, 14, 21, and 28 after ADR injection, and all rats were killed on day 28. We measured the 24-h levels of urinary protein, serum cholesterol, and serum triglycerides, and renal function of all rats by using routine biochemical methods. Pathological changes in the rat kidneys were observed under light and electron microscopes. Heparanase (HPA) mRNA expression levels were measured using re-al-time fluorescence-quantitative polymerase chain reaction. Urine levels of HPA in all groups were measured using enzyme-linked immunosorbent assay. The expression of nephrin was detected by immunohistochemical staining and quantitatively analyzed using Motic image analysis 3.2 software. RESULTS: The levels of urinary protein and serum triglycerides and cholesterol in rats with ADR-induced nephropathy increased on day 14. The serum albumin levels simultaneously decreased. All the changes reached the peak on day 28. Examination under the light microscope showed inflammatory cells and slight fibroplasia in the renal interstitium in the model group, but fewer inflammatory cells were observed in the intervention groups than those in the model group. Examination under the electron microscope showed extensive fusion of foot processes in ADR rats. HPA mRNA expression was higher in the model group than that in the control group. The HPA mRNA levels in the intervention groups, especially in the Chinese herb group, and Chinese herb plus glucocorticoid group were significantly lower than the level in the model group. The HPA expression levels correlated significantly with the proteinuria level. No significant difference was found in the HPA level in urine between the intervention groups and the model group, whereas the model group had a higher urinary HPA level than the control group. Nephrin mRNA expression levels in the model group were higher than those in the control group. Nephrin mRNA expression levels were significantly lower in the intervention groups than that in the model group, especially the Chinese herb plus glucocorticoid group. Compared with the control group, themodel group showed increased nephrin expression in the kidney. Nephrin levels in the other groups, especially in the Chinese herb plus glucocorticoid group, were significantly lower than that in the model group. The nephrin levels in the kidney were negatively correlated with the proteinuria level. CONCLUSION: Yiqiyangyin recipe could attenuate foot process injury particularly in combination with a steroid reduce the development of proteinuria possibly by inhibition of HPA in the kidney, and regulate the expression of nephrin in rats with ADR-induced nephropathy. Our study showed that treatment with Yiqiyangyin recipe plus glucocorticoid was better than a singular intervention, and we explored the pharmacological mechanism of this combination by biochemical and molecular biological analysis to provide a basis for clinical application. | Wen Sun Yongrui He Jian Yu Yanyan Lin Yonghong Wang Xia Gao Ying Wang Zhonghua Zhao Xueguang Liu | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 4 |
| 12 | Targeting β-secretase with RNAi in neural stem cells for Alzheimer's disease therapy显示文摘There are several major pathological changes in Alzheimer's disease,including apoptosis of cholinergic neurons,overactivity or overexpression of β-site amyloid precursor protein cleaving enzyme 1(BACE1) and inflammation.In this study,we synthesized a 19-nt oligonucleotide targeting BACE1,the key enzyme in amyloid beta protein(Aβ) production,and introduced it into the pSilenCircle vector to construct a short hairpin(shRNA) expression plasmid against the BACE1 gene.We transfected this vector into C17.2 neural stem cells and primary neural stem cells,resulting in downregulation of the BACE1 gene,which in turn induced a considerable reduction in reducing Aβ protein production.We anticipate that this technique combining cell transplantation and gene therapy will open up novel therapeutic avenues for Alzheimer's disease,particularly because it can be used to simultaneously target several pathogenetic changes in the disease. | Zhonghua Liu Shengliang Li Zibin Liang Yan Zhao Yulin Zhang Yaqi Yang Minjuan Wang Feng Li | 2013 | Neural Regeneration Research2013，8，33： | 4 |
| 13 | A FAST HIGH ORDER METHOD FOR ELECTROMAGNETIC SCATTERING BY LARGE OPEN CAVITIES显示文摘在这份报纸,从在一架无限的地面飞机嵌入的一个矩形的大开的洞的电磁的散布被学习。由介绍一个非局部的人工的边界条件,来自开的洞的散布问题被归结为一个围住的领域问题。有限差别计划然后被求婚到的 A 协议第四顺序分离在矩形的领域散布模型的洞,和一个特殊处理被强制接近边界调节,它让截断错误到达 O (h [4 ]) 在全部计算领域。一个快算法,利用分离 Fourier 转变在水平并且在垂直方向的 Gaussian 消除,被采用,它把分离系统归结为一个小得多的接口系统。有效 pre-conditioner 被介绍让 BICGstab 反复的解答者解决这个接口系统。数字结果表明建议方法的显著精确性和效率。特别地,为大波浪数字解决洞模型直到 600 能被用来。[从作者抽象] | Meiling Zhao Zhonghua Qiao Tao Tang | 2011 | Journal of Computational Mathematics2011，29，3： | 4 |
| 14 | An Imported Case and an Infected Close Contact of the Omicron Variant of SARS-CoV-2—Guangdong Province,China,December 13,2021显示文摘On November 27,2021,a 67-year-old male returning from Canada via airplane was transferred to the central isolation hotel in Shanghai.During the quarantine,his 1st,4th,7th,and 14th days of specimens returned negative for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which causes coronavirus disease 2019(COVID-19).On December 11,he completed 14 days of centralized isolation and returned to Guangzhou from Shanghai via airplane,then he was closed-loop transferred to Yuexiu District for a 7-day home isolation.On December 12,the local Community Health Service Center routinely collected his throat swab and the result returned to COVID-19 positive on December 13,2021.He was transported to the Guangzhou Eighth People’s Hospital for isolated treatment by negative pressure ambulance on the same day.The patient had two inflamed lungs according to the chest computed tomography(CT)examination,but his most recently updated condition was stable.An estimated 600 close contacts were identified and were placed in centralized isolation.On December 16,one of the close contacts,a 70-year-old female also tested positive for COVID-19.She lived on the lower floor of the same type of apartment as the imported case and spent 19 hours in the same building. | Kuibiao Li Zhonghua Zheng Xiang Zhao Qing Zeng Tengfei Zhou Qianfang Guo Yao Hu Wenbo Xu Zhoubin Zhang Baisheng Li | 2022 | China CDC weekly2022，4，5： | 4 |
| 15 | Cold Stress-induced Glucosyltransferase CsUGT78A15 is Involved in the Formation of Eugenol Glucoside in Camellia sinensis显示文摘Eugenol is a natural phenolic compound known for its health-promoting properties and its ability to add a floral scent to tea plants.Plant eugenol glycosides have been identified and shown to make important contributions to fruit floral quality.However,the details of their biosynthesis and metabolism in tea plants are still unknown.Here,eugenol glucoside was unambiguously identified as a native metabolite in the tea plant,and its biosynthesis was shown to be induced by low temperature treatment.Through the analysis of UGTs induced by low temperature,the glycosyltransferase CsUGT78A15 was identified in tea,and its encoded protein was shown to catalyze the glucosylation of eugenol.Vmax/Km ratios showed that eugenol was the most suitable substrate for CsUGT78A15.Sugar donor preference analysis showed that CsUGT78A15 had a higher selectivity for glucose,followed by galactose and glucuronic acid.The expression of CsUGT78A15was correlatedwith the accumulation of eugenol glucoside in different tissues and genotypes of tea.Down-regulation of CsUGT78A15 led to a decreased eugenol glucoside content under cold stress,indicating that CsUGT78A15 plays an important role in the biosynthesis of eugenol glucoside under cold stress.The identification of eugenol glucoside in the tea plant and the discovery of a cold stress-induced eugenol glucosyltransferase in tea provide the foundation for the improvement of tea flavor under cold stress and the biotechnological production of eugenol glucoside. | Mingyue Zhao Binbin Cai Jieyang Jin Na Zhang Tingting Jing Jingming Wang Yuting Pan Zixiang Zhou Yifan Zhao Yingying Feng Feng Yu Mengting Zhang Yating Li Zhonghua Liu Chuankui Song | 2020 | Horticultural Plant Journal2020，6，6： | 4 |
| 16 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 17 | Tranexamic acid for acute intracerebral haemorrhage growth based on imaging assessment (TRAIGE): a multicentre, randomised, placebo- controlled trial显示文摘Background Studies show tranexamic acid can reduce the risk of death and early neurological deterioration after intracranial haemorrhage.We aimed to assess whether tranexamic acid reduces haematoma expansion and improves outcome in intracerebral haemorrhage patients susceptible to haemorrhage expansion.Methods We did a prospective,double-blind,randomised,placebo-controlled trial at 10 stroke centres in China.Acute supratentorial intracerebral haemorrhage patients were eligible if they had indication of haemorrhage expansion on admission imaging(eg,spot sign,black hole sign or blend sign),and were treatable within 8 hours of symptom onset.Patients were randomly assigned(1:1)to receive either tranexamic acid or a matching placebo.The primary outcome was intracerebral haematoma growth(>33% relative or>6 mL absolute)at 24 hours.Clinical outcomes were assessed at 90 days.Results Of the 171 included patients,124(72.5%)were male,and the mean age was 55.9±11.6 years.89 patients received tranexamic acid and 82 received placebo.The primary outcome did not differ significantly between the groups:36(40.4%)patients in the tranexamic acid group and 34(41.5%)patients in the placebo group had intracranial haemorrhage growth(OR 0.96,95% CI 0.52 to 1.77,p=0.89).The proportion of death was lower in the tranexamic acid treatment group than placebo group(8.1%vs 10.0%),but there were no significant differences in secondary outcomes including absolute intracranial haemorrhage growth,death and dependency.Conclusions Among patients susceptible to haemorrhage expansion treated within 8 hours of stroke onset,tranexamic acid did not significantly prevent intracerebral haemorrhage growth.Larger studies are needed to assess safety and efficacy of tranexamic acid in intracerebral haemorrhage patients. | Jingyi Liu Ximing Nie Hongqiu Gu Qi Zhou Haixin Sun Ying Tan Dacheng Liu Lina Zheng Jiahui Zhao Yan Wang Yibin Cao Haomeng Zhu Yunpeng Zhang Lijin Yi Yuehua Pu Miao Wen Zhonghua Yang Shengjun Sun Wenzhi Wang Xingquan Zhao Liping Liu Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 3 |
| 18 | First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment显示文摘We report the first results on ^(76)Ge neutrinoless double beta decay from stage one of the China dark-matter experiment(CDEX).A p-type point-contact high-purity germanium detector with a mass of 994 g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304 kg d has been analyzed over a wide spectral band from 500 keV to 3 MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039 MeV energy range. The half-life of ^(76)Ge neutrinoless double beta decay derived based on this result is T^(0ν)1/2>6.4×10^(22) yr(90% C.L.). An upper limit on the effective Majorana-neutrino mass of 5.0 eV has been achieved. | Li Wang Qian Yue KeJun Kang JianPing Cheng YuanJing Li TszKing Henry Wong ShinTed Lin JianPing Chang JingHan Chen QingHao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He QingJu He JinWei Hu HanXiong Huang TengRui Huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li XueQian Li YuLan Li FongKay Lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao Wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu WeiBin Zhu ZhongHua Zhu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，7： | 3 |
| 19 | Fixed-Time Output Consensus Tracking for High-Order Multi-Agent Systems With Directed Network Topology and Packet Dropout显示文摘This paper studies the problem of fixed-time output consensus tracking for high-order multi-agent systems(MASs)with directed network topology with consideration of data packet dropout.First,a predictive compensation based distributed observer is presented to compensate for packet dropout and estimate the leader’s states.Next,stability analysis is conducted to prove fixed time convergence of the developed distributed observer.Then,adaptive fixed-time dynamic surface control is designed to counteract mismatched disturbances introduced by observation error,and stabilize the tracking error system within a fixed time,which overcomes explosion of complexity problem and singularity problem.Finally,simulation results are provided to verify the effectiveness and superiority of the consensus tracking strategy proposed.The contribution of this paper is to provide a fixed-time distributed observer design method for high-order MAS under directed graph subject to packet dropout,and a novel fixed-time control strategy which can handle mismatched disturbances and overcome explosion of complexity and singularity problem. | Junkang Ni Peng Shi Yu Zhao Zhonghua Wu | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，4： | 3 |
| 20 | Derivation of Germline Competent Rat Embryonic Stem Cells from DA Rats显示文摘The laboratory rat was one of the earliest mammalian species for scientific research and used as animal disease models in physiology,toxicology,behavior,immunology,and tumor-biology for over 150 years(Jacob,1999).However,rat lags far behind mouse in generating human disease models and functional genomic studies because of the lack of authentic rat embryonic stem(ES) cells(Voigt and Serikawa, 2009),whereas the first mouse ES cell line was established in 1981(Evans and Kaufman,1981).By combining two or three kinase inhibitors which target GSK3,MEK and FGF signaling pathways in serum-free N2B27 medium,germline competent rat ES cells were first derived in 2008(Buehr et al.,2008; | Tianda Li Xiao-Yang Zhao Fei Teng Xin Li Minggui Jiang Wei Li Xuepeng Wang Jialiang Wang Lei Liu Zhonghua Liu Liu Wang Qi Zhou | 2012 | Journal of Genetics and Genomics2012，39，11： | 3 |
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