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| 1 | The wheat MYB-related transcription factor TaMYB72 promotes flowering in rice显示文摘Through large-scale transformation analyses, Ta MYB72 was identified as a flowering time regulator in wheat. Ta MYB72 is a MYB family transcription factor localized to the nucleus. Three Ta MYB72 homologs,Ta MYB72-A, Ta MYB72-B and Ta MYB72-D, cloned from hexaploid wheat were mapped to the short arm of the group 6 chromosomes. Under the long-day conditions,over-expression of the Ta MYB72 in rice shortened the flowering time by approximately 12 d. Expression analyses suggest that Ta MYB72 may function through upregulation of florigen genes Hd3 a and RFT1. | Lichao Zhang Guoxiang Liu Jizeng Jia Guangyao Zhao Chuan Xia Lina Zhang Fu Li Qiang Zhang Chunhao Dong Shuangcheng Gao Longzhi Han Xiuping Guo Xin Zhang Jinxia Wu Xu Liu Xiuying Kong | 2016 | Journal of Integrative Plant Biology2016，58，8： | 8 |
| 2 | WheatGmap:a comprehensive platform for wheat gene mapping and genomic studies显示文摘Bulked segregant analysis(BSA)is an efficient and low-cost strategy that is widely used to identify causal genes in segregating populations.BSA-based methods,such as BSA sequencing(Wenger et al.,2010),bulked segregant RNA sequencing(BSR-seq)(del Viso et al.,2012),and MutMap(Abe et al.,2012),are powerful tools that can be used for rapidly discovering genetic markers and gene mapping.Although BSA is increasingly being used in wheat(Triticum aestivum)gene mapping efforts,few user-friendly BSA tools have been developed for researchers lacking a strong bioinformatics background.Here,we developed the web-based BSA platform WheatGmap(https://www.wheatgmap.org),which integrates multiple BSA mapping models and large amounts of public data to accelerate gene cloning and functional research and facilitate resource sharing. | Lichao Zhang Chunhao Dong Zhongxu Chen Lixuan Gui Cheng Chen Danping Li Zhencheng Xie Qiang Zhang Xueying Zhang Chuan Xia Xu Liu Xiuying Kong Jirui Wang | 2021 | Molecular Plant2021，14，2： | 4 |
| 3 | Short-working-distance optical imaging system and method for surface detection of underwater structures显示文摘In the surface imaging of underwater structures, long working distance will reduce image quality due to the turbidity of water. To acquire high definition and large field of view(FOV) images for surface detection, a short-working-distance underwater imaging system is proposed based on camera array. A multi-view calibration and rectification method is developed. A look-up table(LUT) method and a multi-resolution spline(MRS) method are applied to stitch array images real-time and seamlessly.Experiments both in the air and in the water are conducted. Strength and weakness of the LUT and MRS methods are discussed.Based on the results, the effectiveness in surface detection of underwater structures is verified. | LIU Cong WANG ChengFei XU YingJun LI Xu LUO ChunHao DAI MeiLing SHAO XinXing HE XiaoYuan | 2018 | Science China(Technological Sciences)2018，61，5： | 4 |
| 4 | Numerical simulation of 23 June 2016 Yancheng City EF4 tornadic supercell and analysis of lightning activity显示文摘Based on the Weather Research Forecasting(WRF) model that features charging and discharging parameterization,relationships between tornado, hail and lightning were investigated for a tornado-producing(EF4 intensity) supercell thunderstorm over Yancheng City in Jiangsu Province, China, on 23 June 2016. Based on a sounding at 0800, there was a low lifting condensation level, substantial convective available potential energy(CAPE), and strong vertical wind shear near Yancheng City, which promote supercell development. At 1400, observations revealed that hail production and a dramatic increase of positive cloud-to-ground flash rates occurred simultaneously, maximizing five minutes later. The tornado occurred 30 min after the hail production. The time of minimum positive cloud-to-ground flash rates was 15 min later. The simulation indicated that the tornadic supercell moved eastward and that positive cloud-to-ground flash rates increased dramatically at 1400, the same as observed, but their maximum was 5 min later than observed. The simulated updraft volume peaked at 1425 and the simulated downdraft volume maximized5 min later, when the mesocyclone formed. Simulated reflectivities showed no hook echo and horizontal winds for different height at mid-low levels had a different cyclonic shear at 1430, favorable to mesocyclone formation. Based on the simulated results,the region of positively charged graupel ascended resulting from the region of high liquid water content was lifted by the strong updraft, forming a mid-level strong positive charge region. A lower negative charge region formed by the inductive charging mechanism of collisions between graupel and droplets at the bottom of the cloud, conducive to positive cloud-to-ground flashes. | GUO FengXia LI Yang HUANG ZhaoChu WANG ManFei ZENG FanHui LIAN ChunHao MU YiJun | 2017 | Science China Earth Sciences2017，60，12： | 3 |
| 5 | The method and experiment analysis of two-way common-view satellite time transfer for compass system显示文摘Time synchronization between ground and satellites is a key technology for satellite navigation system. With dual-channel satellite, a method called Two-Way Common-View(TWCV) satellite time transfer for Compass system is proposed, which combines both characteristics of satellite common-view and two-way satellite-ground time transfer. By satellite-ground two-way pseudo-range differencing and two stations common-view differencing, this TWCV method can completely eliminate the influence of common errors, such as satellite clock offset, ephemeris errors, troposphere delay and station coordinates errors. At the same time, ionosphere delay related to signal frequency is also weakened significantly. So the precision of time transfer is improved much more greatly than before. In this paper, the basic principle is introduced in detail, the effect of major errors is analyzed and the practical calculation model in the Earth-fixed coordinate system for this new method is provided. Finally, experiment analysis is conducted with actual Compass observing data. The results show that the deviation and the stability of the satellite dual channel can be better than 0.1 ns, and the accuracy of the two-way common-view satellite time transfer can achieve 0.4 ns. All these results have verified the correctness of this TWCV method and model. In addition, we compare this TWCV satellite time transfer with the independent C-band TWSTFT(Two-Way Satellite Time and Frequency Transfer). It shows that the result of the TWCV satellite time transfer is in accordance with the C-band TWSTFT result, which further suggests that the TWCV method is a remote high precision time transfer technique. The research results in this paper are very important references for the development and application of Compass satellite navigation system. | LIU Li TANG GuiFen HAN ChunHao SHI Xin GUO Rui ZHU LingFeng | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，8： | 2 |
| 6 | The space-time references of BeiDou Navigation Satellite System显示文摘The BeiDou Navigation Satellite System (BDS) is essentially a precise time measurement and time synchronization system for a large-scale space near the Earth. General relativity is the basic theoretical framework for the information processing in the master control station of BDS. Having introduced the basic conceptions of relativistic space-time reference systems, the space-time references of BDS are analyzed and the function and acquisition method of the Earth Orientation Parameters (EOP) are briefly discussed. The basic space reference of BDS is BeiDou Coordinate System (BDCS), and the time standard is the BDS Time (BDT). BDCS and BDT are the realizations of the Geocentric Terrestrial Reference System (GTRS) and the Terrestrial Time (TT) for BDS, respectively. The station coordinates in the BDCS are consistent with those in International Terrestrial Reference Frame (ITRF)2014 at the cm-level and the difference in scale is about 1.1 × 10^(−8) . The time deviation of BDT relative to International Atomic Time (TAI) is less than 50 ns and the frequency deviation is less than 2 × 10^(−14) . The Geocentric Celestial Reference System (GCRS) and the solar Barycentric Celestial Reference System (BCRS) are also involved in the operation of BDS. The observation models for time synchronization and precise orbit determination are established within the GCRS framework. The coordinate transformation between BDCS and GCRS is consistent with the International Earth Rotation and Reference Systems Service (IERS). In the autonomous operation mode without the support of the ground master control station, Earth Orientation Parameters (EOP) is obtained by means of long-term prediction and on-board observation. The observa-tion models for the on-board astrometry should be established within the BCRS framework. | Chunhao Han Li Liu Zhiwu Cai Yuting Lin | 2021 | Satellite Navigation2021，2，1： | 2 |
| 7 | Erratum to Simultaneous inhibition of PI3Kα and CDK4/6synergistically suppresses KRAS-mutated non-small cell lung cancer显示文摘In the published Figure 11,errors appeared in Figure 1B on page 69.In Figure 1B,bands for p-Akt S473,Akt,and Actin in H1355 cells were mistakenly placed.Here,we have updated Figure 1B to correct the mistake above.The errors do not impact the conclusions of this article.We apologize for the errors and for any confusion it may have caused. | Yuxiang Wang Xian Li Xueling Liu Yi Chen Chunhao Yang Cun Tan Bobo Wang Yiming Sun Xi Zhang Yinglei Gao Jian Ding Linghua Meng | 2019 | Cancer Biology & Medicine2019，16，4： | 1 |
| 8 | Investigation of Structure and Magnetic Properties of Rare Earth-Leaned Pr2 ( Fe, Co) 14 ( C, B ) Type Nanocomposites 显示文摘 | Li Anhua Chiu Chunhao Chang W C | 2006 | Journal of Iron and Steel Research2006，13，： | 1 |
| 9 | Effect of low-voltage electrical stimulation after dressing on color stability and water holding capacity of bovine longissimus muscle显示文摘 | Li Chunhao Li Jing Li Xin | | 0，，： | 1 |
| 10 | Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO显示文摘The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment. | Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera Daojin Hong YuenKeung Hor Shaojing Hou Yee Hsiung Bei-Zhen Hu Hang Hu Jianrun Hu Jun Hu Shouyang Hu Tao Hu Zhuojun Hu Chunhao Huang Guihong Huang Hanxiong Huang Qinhua Huang Wenhao Huang Xingtao Huang Yongbo Huang Jiaqi Hui Wenju Huo Cédric Huss Safeer Hussain Antonio Insolia Ara Ioannisian Daniel Ioannisyan Roberto Isocrate Kuo-Lun Jen Xiaolu Ji Xingzhao Ji Huihui Jia Junji Jia Siyu Jian Di Jiang Xiaoshan Jiang Ruyi Jin Xiaoping Jing Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Kampmann Li Kang Michael Karagounis Narine Kazarian Amir Khan Waseem Khan Khanchai Khosonthongkee Patrick Kinz Denis Korablev Konstantin Kouzakov Alexey Krasnoperov Svetlana Krokhaleva Zinovy Krumshteyn Andre Kruth Nikolay Kutovskiy Pasi Kuusiniemi Tobias Lachenmaier Cecilia Landini Sébastien Leblanc Frederic Lefevre Liping Lei Ruiting Lei Rupert Leitner Jason Leung Demin Li Fei Li Fule Li Haitao Li Huiling Li Jiaqi Li Jin Li Kaijie Li Mengzhao Li Nan Li Nan Li Qingjiang Li Ruhui Li Shanfeng Li Shuaijie Li Tao Li Weidong Li Weiguo Li Xiaomei Li Xiaonan Li Xinglong Li Yi Li Yufeng Li Zhibing Li Ziyuan Li Hao Liang Hao Liang Jingjing Liang Jiajun Liao Daniel Liebau Ayut Limphirat Sukit Limpijumnong Guey-Lin Lin Shengxin Lin Tao Lin Jiajie Ling Ivano Lippi Fang Liu Haidong Liu Hongbang Liu Hongjuan Liu Hongtao Liu Hu Liu Hui Liu Jianglai Liu Jinchang Liu Min Liu Qian Liu Qin Liu Runxuan Liu Shuangyu Liu Shubin Liu Shulin Liu Xiaowei Liu Yan Liu Alexey Lokhov Paolo Lombardi Claudio Lombardo Kai Loo Chuan Lu Haoqi Lu Jingbin Lu Junguang Lu Shuxiang Lu Xiaoxu Lu Bayarto Lubsandorzhiev Sultim Lubsandorzhiev Livia Ludhova Fengjiao Luo Guang Luo Pengwei Luo Shu Luo Wuming Luo Vladimir Lyashuk Qiumei Ma Si Ma Xiaoyan Ma Xubo Ma Jihane Maalmi Yury Malyshkin Fabio Mantovani Francesco Manzali Xin Mao Yajun Mao Stefano MMari Filippo Marini Sadia Marium Cristina Martellini Gisele Martin-Chassard Agnese Martini Davit Mayilyan Axel Müller Ints Mednieks Yue Meng Anselmo Meregaglia Emanuela Meroni David Meyhöfer Mauro Mezzetto Jonathan Miller Lino Miramonti Salvatore Monforte Paolo Montini Michele Montuschi Nikolay Morozov Pavithra Muralidharan Massimiliano Nastasi Dmitry VNaumov Elena Naumova Igor Nemchenok Alexey Nikolaev Feipeng Ning Zhe Ning Hiroshi Nunokawa Lothar Oberauer Juan Pedro Ochoa-Ricoux Alexander Olshevskiy Domizia Orestano Fausto Ortica Hsiao-Ru Pan Alessandro Paoloni Nina Parkalian Sergio Parmeggiano Teerapat Payupol Yatian Pei Nicomede Pelliccia Anguo Peng Haiping Peng Frédéric Perrot Pierre-Alexandre Petitjean Fabrizio Petrucci Luis Felipe Piñeres Rico Oliver Pilarczyk Artyom Popov Pascal Poussot Wathan Pratumwan Ezio Previtali Fazhi Qi Ming Qi Sen Qian Xiaohui Qian Hao Qiao Zhonghua Qin Shoukang Qiu Muhammad Rajput Gioacchino Ranucci Neill Raper Alessandra Re Henning Rebber Abdel Rebii Bin Ren Jie Ren Taras Rezinko Barbara Ricci Markus Robens Mathieu Roche Narongkiat Rodphai Aldo Romani Bedřich Roskovec Christian Roth Xiangdong Ruan Xichao Ruan Saroj Rujirawat Arseniy Rybnikov Andrey Sadovsky Paolo Saggese Giuseppe Salamanna Simone Sanfilippo Anut Sangka Nuanwan Sanguansak Utane Sawangwit Julia Sawatzki Fatma Sawy Michaela Schever Jacky Schuler Cédric Schwab Konstantin Schweizer Dmitry Selivanov Alexandr Selyunin Andrea Serafini Giulio Settanta Mariangela Settimo Muhammad Shahzad Vladislav Sharov Gang Shi Jingyan Shi Yongjiu Shi Vitaly Shutov Andrey Sidorenkov FedorŠimkovic Chiara Sirignano Jaruchit Siripak Monica Sisti Maciej Slupecki Mikhail Smirnov Oleg Smirnov Thiago Sogo-Bezerra Julanan Songwadhana Boonrucksar Soonthornthum Albert Sotnikov Ondrej Sramek Warintorn Sreethawong Achim Stahl Luca Stanco Konstantin Stankevich DušanŠtefánik Hans Steiger Jochen Steinmann Tobias Sterr Matthias Raphael Stock Virginia Strati Alexander Studenikin Gongxing Sun Shifeng Sun Xilei Sun Yongjie Sun Yongzhao Sun Narumon Suwonjandee Michal Szelezniak Jian Tang Qiang Tang Quan Tang Xiao Tang Alexander Tietzsch Igor Tkachev Tomas Tmej Konstantin Treskov Andrea Triossi Giancarlo Troni Wladyslaw Trzaska Cristina Tuve Stefan van Waasen Johannes van den Boom Guillaume Vanroyen Nikolaos Vassilopoulos Vadim Vedin Giuseppe Verde Maxim Vialkov Benoit Viaud Cristina Volpe Vit Vorobel Lucia Votano Pablo Walker Caishen Wang Chung-Hsiang Wang En Wang Guoli Wang Jian Wang Jun Wang Kunyu Wang Lu Wang Meifen Wang Meng Wang Ruiguang Wang Siguang Wang Wei Wang Wenshuai Wang Xi Wang Xiangyue Wang Yangfu Wang Yaoguang Wang Yi Wang Yifang Wang Yuanqing Wang Yuman Wang Zhe Wang Zheng Wang Zhimin Wang Zongyi Wang Apimook Watcharangkool Lianghong Wei Wei Wei Yadong Wei Liangjian Wen Christopher Wiebusch Steven Chan-Fai Wong Bjoern Wonsak Diru Wu Fangliang Wu Qun Wu Wenjie Wu Zhi Wu Michael Wurm Jacques Wurtz Christian Wysotzki Yufei Xi Dongmei Xia Yuguang Xie Zhangquan Xie Zhizhong Xing Benda Xu Donglian Xu Fanrong Xu Jilei Xu Jing Xu Meihang Xu Yin Xu Yu Xu Baojun Yan Xiongbo Yan Yupeng Yan Anbo Yang Changgen Yang Huan Yang Jie Yang Lei Yang Xiaoyu Yang Yifan Yang Haifeng Yao Zafar Yasin Jiaxuan Ye Mei Ye Ugur Yegin Frédéric Yermia Peihuai Yi Xiangwei Yin Zhengyun You Boxiang Yu Chiye Yu Chunxu Yu Hongzhao Yu Miao Yu Xianghui Yu Zeyuan Yu Chengzhuo Yuan Ying Yuan Zhenxiong Yuan Ziyi Yuan Baobiao Yue Noman Zafar Andre Zambanini Pan Zeng Shan Zeng Tingxuan Zeng Yuda Zeng Liang Zhan Feiyang Zhang Guoqing Zhang Haiqiong Zhang Honghao Zhang Jiawen Zhang Jie Zhang Jingbo Zhang Peng Zhang Qingmin Zhang Shiqi Zhang Tao Zhang Xiaomei Zhang Xuantong Zhang Yan Zhang Yinhong Zhang Yiyu Zhang Yongpeng Zhang Yuanyuan Zhang Yumei Zhang Zhenyu Zhang Zhijian Zhang Fengyi Zhao Jie Zhao Rong Zhao Shujun Zhao Tianchi Zhao Dongqin Zheng Hua Zheng Minshan Zheng Yangheng Zheng Weirong Zhong Jing Zhou Li Zhou Nan Zhou Shun Zhou Xiang Zhou Jiang Zhu Kejun Zhu Honglin Zhuang Liang Zong Jiaheng Zou | 2021 | Chinese Physics C2021，45，2： | 0 |
| 11 | An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19显示文摘The global spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019(COVID-19).In this study,we developed an integrative drug repositioning framework,which fully takes advantage of machine learning and statistical analysis approaches to systematically integrate and mine large-scale knowledge graph,literature and transcriptome data to discover the potential drug candidates against SARS-CoV-2.Our in silico screening followed by wet-lab validation indicated that a poly-ADP-ribose polymerase 1(PARP1)inhibitor,CVL218,currently in Phase I clinical trial,may be repurposed to treat COVID-19.Our in vitro assays revealed that CVL218 can exhibit effective inhibitory activity against SARS-CoV-2 replication without obvious cytopathic effect.In addition,we showed that CVL218 can interact with the nucleocapsid(N)protein of SARS-CoV-2 and is able to suppress the LPS-induced production of several inflammatory cytokines that are highly relevant to the prevention of immunopathology induced by SARS-CoV-2 infection. | Yiyue Ge Tingzhong Tian Suling Huang Fangping Wan Jingxin Li Shuya Li Xiaoting Wang Hui Yang Lixiang Hong Nian Wu Enming Yuan Yunan Luo Lili Cheng Chengliang Hu Yipin Lei Hantao Shu Xiaolong Feng Ziyuan Jiang Yunfu Wu Ying Chi Xiling Guo Lunbiao Cui Liang Xiao Zeng Li Chunhao Yang Zehong Miao Ligong Chen Haitao Li Hainian Zeng Dan Zhao Fengcai Zhu Xiaokun Shen Jianyang Zeng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 12 | A New EMG Decomposition Framework for Upper Limb Prosthetic Systems显示文摘Neural interfaces based on surface Electromyography(EMG)decomposition have been widely used in upper limb prosthetic systems.In the current EMG decomposition framework,most Blind Source Separation(BSS)algorithms require EMG with a large number of channels(generally larger than 64)as input,while users of prosthetic limbs can generally only provide less skin surface for electrode placement than healthy people.We performed decomposition tests to demonstrate the performance of the new framework with the simulated EMG signal.The results show that the new framework identified more Motor Units(MUs)compared to the control group and it is suitable for decomposing EMG signals with low channel numbers.In order to verify the application value of the new framework in the upper limb prosthesis system,we tested its performance in decomposing experimental EMG signals in force fitting experiments as well as pattern recognition experiments.The average Pearson coefficient between the fitted finger forces and the ground truth forces is 0.9079 and the average accuracy of gesture classification is 95.11%.The results show that the decomposition results obtained by the new framework can be used in the control of the upper limb prosthesis while only requiring EMG signals with fewer channels. | Wenhao Wu Li Jiang Bangchu Yang Kening Gong Chunhao Peng Tianbao He | 2023 | Journal of Bionic Engineering2023，20，6： | 0 |
| 13 | Stress-Regulation Design of Lithium Alloy Electrode toward Stable Battery Cycling显示文摘Metallic tin(Sn)foil is a promising candidate anode for lithium-ion batteries(LIBs)due to its metallurgical processability and high capacity.However,it suffers low initial Coulombic efficiency and inferior cycling stability due to its uneven alloying/dealloying reactions,large volume change and stress,and fast electrode structural degradation.Herein,we report an undulating LiSn electrode fabricated by a scalable two-step procedure involving mechanical lithography and chemical prelithiation of Sn foil.With the combination of experimental measurements and chemo-mechanical simulations,it was revealed the obtained undulating LiSn/Sn electrode could ensure better mechanical stability due to the pre-swelling state from Sn to Li x Sn and undulating structure of lithography in comparison with plane Sn,homogenize the electrochemical alloying/dealloying reactions due to the activated surface materials,and compensate Li loss during cycling due to the introduction of excess Li from Li_(x)Sn,thus enabling enhanced electrochemical performance.Symmetric cells consisting of undulating LiSn/Sn electrode with an active thickness of∼5 um displayed stable cycling over 1000 h at 1 mA cm^(-2) and 1 mAh cm^(-2) with a low average overpotential of<15 mV.When paired with commercial LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2)(NCM622)cathode with high mass loading of 15.8 mg cm^(-2),the full cell demonstrated a high capacity of 2.4 mAh cm^(-2) and outstanding cycling stability with 84.9% capacity retention at 0.5 C after 100 cycles.This work presents an advanced LiSn electrode with stress-regulation design toward high-performance LIBs,and sheds light on the rational electrode design and processing of other high-capacity lithium alloy anodes. | Chunhao Li Shuibin Tu Xin Ai Siwei Gui Zihe Chen Wenyu Wang Xiaoxiao Liu Yuchen Tan Hui Yang Yongming Sun | 2023 | Energy & Environmental Materials2023，6，1： | 0 |
| 14 | Robust measurement of orbital angular momentum of a partially coherent vortex beam under amplitude and phase perturbations显示文摘The ability to overcome the negative effects,induced by obstacles and turbulent atmosphere,is a core challenge of long-distance information transmission,and it is of great significance in free-space optical communication.The spatial-coherence structure,that characterizes partially coherent fields,provides a new degree of freedom for carrying information.However,due to the influence of the complex transmission environment,the spatial-coherence structure is severely damaged during the propagation path,which undoubtedly limits its ability to transmit information.Here,we realize the robust far-field orbital angular momentum(OAM)transmission and detection by modulating the spatial-coherence structure of a partially coherent vortex beam with the help of the cross-phase.The cross-phase enables the OAM information,quantified by the topological charge,hidden in the spatial-coherence structure can be stably transmitted to the far field and can resist the influence of obstructions and turbulence within the communication link.This is due to the self-reconstruction property of the spatial-coherence structure embedded with the cross-phase.We demonstrate experimentally that the topological charge information can be recognized well by measuring the spatial-coherence structure in the far field,exhibiting a set of distinct and separated dark rings even under amplitude and phase perturbations.Our findings open a door for robust optical signal transmission through the complex environment and may find application in optical communication through a turbulent atmosphere. | Zhao Zhang Gaoyuan Li Yonglei Liu Haiyun Wang Bernhard J.Hoenders Chunhao Liang Yangjian Cai Jun Zeng | 2024 | Opto-Electronic Science2024，3，1： | 0 |
| 15 | Long-term hydrological impacts of land use/land cover change from 1984 to 2010 in the Little River Watershed,Tennessee显示文摘Assessing long-term hydrological impacts of land use/land cover(LULC)change is of critical importance for land use planning and water resource management.The Little River Watershed,Tennessee,is an important watershed supporting drinking water and recreational activities within and around the Great Smoky Mountains National Park in the Unites States.However,the potential hydrological impacts of LULC change,especially urbanization in recent decades,are not quantified.This paper assessed the long-term impacts of LULC change on streamflow and non-point source pollution using the Soil and Water Assessment Tool(SWAT)and a detailed LULC record from 1984 to 2010.The SWAT was first calibrated and validated using observed streamflowin 2010 and then simulated using different LULC patterns in 1984-2010 to quantify the long-term hydrological impacts caused by the LULC change.Simulated results indicated a minor 3%increase in streamflow for the whole watershed from 1984 to 2010,but with a distinct spatial pattern.The increase in streamflow is closely related to urban development.Almost no streamflow increase occurred in the upper watershed within the national park,whereas>10%increase occurred in the lower watershed,especially in areas close to cities.Model simulation also suggested 34.6%reduction in sediment and about 10%reduction in nutrient loads from 1984 to 2010,closely related to the decrease in agricultural land.However,without calibration and validation,the simulated reduction in the sediment and nutrient loads may be problematic because SWAT mainly simulates the static LULC patterns,whereas LULC transitions,such as construction phases,may generate more sediment and nutrient loads.In addition,the simulation also did not account for the sediment and nutrients generated from stream bank erosion. | Chunhao Zhu Yingkui Li | 2014 | International Soil and Water Conservation Research2014，2，2： | 0 |
| 16 | Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer显示文摘Objective: Activating KRAS mutations are the most common drivers in the development of non-small cell lung cancer(NSCLC).However, unsuccess of treatment by direct inhibition of KRAS has been proven. Deregulation of PI3K signaling plays an important role in tumorigenesis and drug resistance in NSCLC. The activity of PI3Kα-selective inhibition against KRAS-mutated NSCLC remains largely unknown.Methods: Cell proliferation was detected by sulforhodamine B assay. Cell cycle distribution and apoptosis were measured by flow cytometry. Cell signaling was assessed by Western blot and immunohistochemistry. RNA interference was used to down-regulate the expression of cyclin D1. Human NSCLC xenografts were employed to detect therapeutic efficacy in vivo.Results: CYH33 possessed variable activity against a panel of KRAS-mutated NSCLC cell lines. Although CYH33 blocked AKT phosphorylation in all tested cells, Rb phosphorylation decreased in CYH33-sensitive, but not in CYH33-resistant cells, which was consistent with G1 phase arrest in sensitive cells. Combined treatment with the CDK4/6 inhibitor, PD0332991, and CYH33 displayed synergistic activity against the proliferation of both CYH33-sensitive and CYH33-resistant cells, which was accompanied by enhanced G1-phase arrest. Moreover, down-regulation of cyclin D1 sensitized NSCLC cells to CYH33. Reciprocally, CYH33 abrogated the PD0332991-induced up-regulation of cyclin D1 and phosphorylation of AKT in A549 cells. Co-treatment with these two drugs demonstrated synergistic activity against A549 and H23 xenografts, with enhanced inhibition of Rb phosphorylation.Conclusions: Simultaneous inhibition of PI3Kα and CDK4/6 displayed synergistic activity against KRAS-mutated NSCLC. These data provide a mechanistic rationale for the combination of a PI3Kα inhibitor and a CDK4/6 inhibitor for the treatment of KRASmutated NSCLC. | Yuxiang Wang Xian Li Xueling Liu Yi Chen Chunhao Yang Cun Tan Bobo Wang Yiming Sun Xi Zhang Yinglei Gao Jian Ding Linghua Meng | 2019 | Cancer Biology & Medicine2019，16，1： | 0 |
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