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| 1 | Effect of pre-moxibustion on apoptosis and proliferation of gastric mucosa cells显示文摘瞄准:与导致压力的溃疡在老鼠在胃的粘膜房间的 apoptosis 和增长上观察艾灸前的效果,并且分析在那些效果和热吃惊蛋白质 70 的表示(HSP70 ) 之间的关系。方法:六十只健康 Sprague Dawley 老鼠随机被分配进四个组,也就是组织 A, B, C 和 D。压力溃疡的动物模型走水路被建立沉浸和抑制应力。分别地,当那些在 Zusanli 和 Liangmen 点在组 C 收到了艾灸时,在组 A, B,和 D 的老鼠用作抑制,模型,和 non-acupoint 控制。Immunohistochemical 方法论被用来检测 HSP70 的表示, apoptosis 索引(AI,乘 10-6/mum2 ) 并且增长索引(PCNA-LI,乘 10-6/mum2 ) 。转变生长因素高山的粘膜表示哈(TGF-alpha ) 被放射性免疫测定检测。结果:在 Zusanli 和 Liangmen 点的艾灸显著地减少了胃的损害和胃的粘膜房间的 apoptosis,当显著地增加了时象胃的粘膜房间的增长一样的 TGF-alpha 和 HSP70 的粘膜表示。与组 A 相比,溃疡索引( UI )( 26.8 +/- 9.8 对 12.0 +/- 5.9 , P <
0.01 ), AI ( 9.6 +/- 4.2 对 4.4 +/- 2.6 , P <
0.05 )并且 HSP70 的表示( 9.6 +/- 4.2 对 4.4 +/- 2.6 , P <
0.05 )显著地被增加,但是 TGF-alpha 的内容( 104.7 +/- 51.2 pg/mL 对 254.0 +/- 86.9 pg/mL , P <
0.01 )并且 PCNA-LI ( 6.9 +/- 4.7 对 14.9 +/- 4.6 , P <
0.05 )显著地在组 B 被减少。然而,溃疡索引价值(UI ) 和 AI 在与组 B 和 D 相比的组 C 显然是更低的(14.1 +/- 5.4 对 26.8 +/- 9.8 和 26.2 +/- 7.7, P <
0.01; 3.0 +/- 1.6 对 9.6 +/- 4.2 和 8.2 +/- 5.2 , P <
0.05 ,分别地),但是 TGF-alpha 的内容( 237.0 +/- 72.6 pg/mL 对 104.7 +/- 51.2 pg/mL 和 154.1 +/- 61.3 pg/mL , P <
0.01 )并且 HSP70 的表示( 0.13 +/- 0.03 对 0.08 +/- 0.06 和 0.06 +/- 0.04 , P <
0.05 )在组 C 是更高的。而且, PCNA-LI 比在组 B 在组 C 是显著地更高的(21.6 +/- 4.1 对 6.9 +/- 4.7, P <
0.01 ) 。结论:在 Zusanli 和 Liangmen 点的艾灸在支持 TGF-alpha 的合成和胃的粘膜房间的增长与它的行动有关仔细在导致压力的胃溃疡在老鼠胃粘膜上有保护的效果,它是,压制胃的粘膜房间 apoptosis,和起来调整的 HSP70 表示。 | Shou-Xiang Yi Yan Peng Xiao-Rong Chang Na Peng Jie Yan Yap-Ping Lin | 2007 | World Journal of Gastroenterology2007，13，15： | 25 |
| 2 | Ion Channel Genes and Epilepsy:Functional Alteration,Pathogenic Potential,and Mechanism of Epilepsy显示文摘Ion channels are crucial in the generation and modulation of excitability in the nervous system and have been implicated in human epilepsy. Forty-one epilepsyassociated ion channel genes and their mutations are systematically reviewed. In this paper, we analyzed the genotypes, functional alterations(funotypes), and phenotypes of these mutations. Eleven genes featured loss-offunction mutations and six had gain-of-function mutations.Nine genes displayed diversified funotypes, among which a distinct funotype-phenotype correlation was found in SCN1A. These data suggest that the funotype is an essential consideration in evaluating the pathogenicity of mutations and a distinct funotype or funotype-phenotype correlation helps to define the pathogenic potential of a gene. | Feng Wei Li-Min Yan Tao Su Na He Zhi-Jian Lin Jie Wang Yi-Wu Shi Yong-Hong Yi Wei-Ping Liao | 2017 | Neuroscience Bulletin2017，33，4： | 21 |
| 3 | Role of penehyclidine in acute organophosphorus pesticide poisoning显示文摘BACKGROUND:Penehyclidine is a newly developed anticholinergic agent.We aimed to investigate the role of penehyclidine in acute organophosphorus pesticide poisoning(OP)patients.METHODS:We searched the Pubmed,Cochrane library,EMBASE,Chinese National Knowledge Infrastructure(CNKI),Chinese Biomedical literature(CBM)and Wanfang databases.Randomized controlled trials(RCTs)recruiting acute OP patients were identifi ed for meta-analysis.Main outcomes included cure rate,mortality rate,time to atropinization,time to 60%normal acetylcholinesterase(AchE)level,rate of intermediate syndrome(IMS)and rate of adverse drug reactions(ADR).RESULTS:Sixteen RCTs involving 1,334 patients were identifi ed.Compared with the atropineor penehyclidine-alone groups,atropine combined with penehyclidine significantly increased the cure rate(penehyclidine+atropine vs.atropine,0.97 vs.0.86,RR 1.13,95%CI[1.07–1.19];penehyclidine+atropine vs.penehyclidine,0.93 vs.0.80,RR 1.08,95%CI[1.01–1.15])and reduced the mortality rate(penehyclidine+atropine vs.atropine,0.015 vs.0.11,RR 0.17,95%CI[0.06–0.49];penehyclidine+atropine vs.penehyclidine,0.13 vs.0.08,RR 0.23,95%CI[0.04–1.28]).Atropine combined with penehyclidine in OP patients also helped reduce the time to atropinization and AchE recovery,the rate of IMS and the rate of ADR.Compared with a single dose of atropine,a single dose of penehyclidine also signifi cantly elevated the cure rate,reduced times to atropinization,AchE recovery,and rate of IMS.CONCLUSION:Atropine combined with penehyclidine benefi ts OP patients by enhancing the cure rate,mortality rate,time to atropinization,AchE recovery,IMS rate,total ADR and duration of hospitalization.Penehyclidine combined with atropine is likely a better initial therapy for OP patients than atropine alone. | Shi-yuan Yu Yan-xia Gao Joseph Walline Xin Lu Li-na Zhao Yuan-xu Huang Jiang Tao An-yong Yu Na Ta Ren-ju Xiao Yi Li | 2020 | World Journal of Emergency Medicine2020，11，1： | 18 |
| 4 | Effect of Deficit Irrigation on the Growth, Water Use Characteristics and Yield of Cotton in Arid Northwest China显示文摘Water shortage is a key constraint to sustainable agricultural production in Xinjiang, Northwest China. To enhance the use efficiency of valuable irrigation water resources, a 2-year experiment(2010–2011) was conducted to quantify the response of cotton(Gossypium hirsutum L.) growth and yield to different degrees of deficit irrigation(DI) regimes; to determine the effects of DI on the characteristics of water use for cotton, seasonal water use, available soil water in the root zone, soil water depletion, evapotranspiration(ET)-based water use efficiency and irrigation-based water use efficiency, and to determine the best DI regime for optimal water-saving and yield output. The plots were irrigated at 100%(100ET), 85%(85ET), 70%(70ET), 55%(55ET) and 45%(45ET) of the regional ET of cotton in northern Xinjiang. The effect of DI irrigation on water use characteristics was evaluated by analyzing available soil water and soil water depletion in the root zone along with water use efficiencies of cotton. The study showed that the growth, water use characteristics and yield of cotton varied with irrigation regime. Seasonal ET and seed cotton yield were linearly correlated with irrigation amount. The second-order polynomial equation best approximated water-yield relationship of cotton in the study area.Cotton yield response factor was 0.65, suggesting limited water conditions were suitable for cotton cultivation. Economic evaluation of DI treatments confirmed that the yield loss was less than 10% under 70 ET and 85 ET, which was acceptable for greater sustainability.The results suggested that proper DI schemes were necessary for sustainable cotton production in the region. While irrigation at 85 ET was safe for high cotton yield, irrigation at 70 ET was a viable alternative under limited irrigation water availability. | YANG Chuanjie LUO Yi SUN Lin WU Na | 2015 | Pedosphere2015，25，6： | 17 |
| 5 | Reinfection rate and endoscopic changes after successful eradication of Helicobacter pylori显示文摘AIM:To determine the long-term outcomes regarding reinfection with Helicobacter pylori(H.pylori)and endoscopic changes after successful H.pylori eradication. METHODS:From June 1994 to January 2007,186 patients(M:F=98:88;mean age 50.0±11.4 years), in whom H.pylori had been successfully eradicated, were enrolled.The mean duration of follow up was 41.2±24.0 mo. RESULTS:H.pylori reinfection occurred in 58 patients (31.2%).The average annual reinfection rate was 9.1% per patient year.No recurrence of peptic ulcer was detected at the follow up endoscopy.There were no significant differences between the H.pylori eradication regimens for the reinfection rate and no significant differences in endoscopic findings between the H.pylorirecurred group and the H.pylori-cured group.CONCLUSION:The reinfection rate in Korea is 9.1% which represents a decreasing trend.There was no relationship between H.pylori infection status and changes in endoscopic findings.There was also no recurrence or aggravation of ulcers. | Kum Hei Ryu Sun Young Yi Youn Ju Na Su Jung Baik Su Jin Yoon Hae-Sun Jung Hyun Joo Song | 2010 | World Journal of Gastroenterology2010，16，2： | 14 |
| 6 | The Performance of Whole Genome Amplification Methods and Next-Generation Sequencing for Pre-Implantation Genetic Diagnosis of Chromosomal Abnormalities显示文摘Reliable and accurate pre-implantation genetic diagnosis(PGD) of patient's embryos by next-generation sequencing(NGS) is dependent on efficient whole genome amplification(WGA) of a representative biopsy sample. However, the performance of the current state of the art WGA methods has not been evaluated for sequencing. Using low template DNA(15 pg) and single cells, we showed that the two PCR-based WGA systems Sure Plex and MALBAC are superior to the REPLI-g WGA multiple displacement amplification(MDA) system in terms of consistent and reproducible genome coverage and sequence bias across the 24 chromosomes, allowing better normalization of test to reference sequencing data. When copy number variation sequencing(CNV-Seq) was applied to single cell WGA products derived by either Sure Plex or MALBAC amplification, we showed that known disease CNVs in the range of 3e15 Mb could be reliably and accurately detected at the correct genomic positions. These findings indicate that our CNV-Seq pipeline incorporating either Sure Plex or MALBAC as the key initial WGA step is a powerful methodology for clinical PGD to identify euploid embryos in a patient's cohort for uterine transplantation. | Na Li Li Wang Hui Wang Minyue Ma Xiaohong Wang Yi Li Wenke Zhang Jianguang Zhang David S.Cram Yuanqing Yao | 2015 | Journal of Genetics and Genomics2015，42，4： | 13 |
| 7 | Fabrication,microstructures,and properties of copper matrix composites reinforced by molybdenum-coated carbon nanotubes显示文摘Multiwalled carbon nanotubes(CNTs) were coated by a molybdenum layer using carbonyl thermal decomposition process with a precursor of molybdenum hexacarbonyl.The Mo-coated CNTs(Mo-CNTs) were added into copper powders to fabricate Mo-CNT/Cu composites by means of mechanical milling followed by spark plasma sintering.The Mo-CNTs were uniform dispersion in the Cu matrix when their contents were 2.5 vol.%-7.5 vol.%,while some Mo-CNT clusters were clearly observed at additions of 10.0 vol.%-15.0 vol.% Mo-CNTs in the mixture.The mechanical,electrical,and thermal properties of the Mo-CNT/Cu composites were characterized,and the results showed that the tensile strength and hardness were 2.0 and 2.2 times higher than those of CNT-free specimens,respectively.Moreover,the Mo-CNT/Cu composites exhibited an enhanced thermal conductivity but inferior electrical conductivity compared with sintered pure Cu.The uncoated CNT/Cu composites were fabricated by the similar processes,and the measured tensile strength,hardness,thermal conductivity,and electrical conductivity of the CNT/Cu composites were lower than those of the Mo-CNT/Cu composites. | NIE Junhui JIA Chengchang JIA Xian ZHANG Yafeng SHI Na LI Yi | 2011 | Rare Metals2011，30，4： | 12 |
| 8 | Urban expansion in China and its effect on cultivated land before and after initiating'Reform and Open Policy'显示文摘Urbanization in China has expanded at an unprecedented speed since the declaration of 'Reform and Open Policy'and presented many challenges. Unbalanced regional development, appearance of super megacities and concomitant problems,and conflicts between urbanization and cultivated land protection are three critical problems that Chinese urbanization has to face. To develop new plans for foreseeable future urbanization in China, it is critical to understand the evolving history of cities across China. This study maps urban expansion of 60 typical Chinese cities based on large amount of remote sensing data and the labor-intensive image interpretation method, in order to understand the history of urban expansion from the 1970 s to 2013.Results showed that area of cities expanded 5.23 times compared to their area in the 1970 s. Urban expansion in China accelerated three times(1988–1996, 1999–2006, and 2009–2011) and decelerated three times(1997–1998, 2007–2008, and 2012–2013) over the 40 years. The urban area of South China expanded most significantly 9.42 times, while the urban area in Northeast China expanded only 2.37 times. The disparity among different administrative ranks of cities was even greater than(3.81 times) the differences among different regions. Super megacities have been continuously expanding at a fast rate(8.60-fold), and have not shown obvious signs of slowing down. The proportion of cultivated land among the land sources for urban expansion decreased to a small extent in the 1990 s, but cultivated land continues to be the major land source for urban expansion. Effective future urbanization needs controlling the expansion scale of large cities and reasonably developing medium and small cities, as well as balancing regional development. | ZHANG ZengXiang WEN QingKe LIU Fang ZHAO XiaoLi LIU Bin XU JinYong YI Ling HU ShunGuang WANG Xiao ZUO LiJun LI Na LI MinMin SHI LiFeng ZENG Tian JU HongRun | 2016 | Science China Earth Sciences2016，59，10： | 12 |
| 9 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 10 | Value of abdominal ultrasound scan, CT and MRI for diagnosing inferior vena cava tumour thrombus in renal cell carcinoma显示文摘我们使用了的背景腹的超声扫描(美国船),在肾的房间癌( RCC )的静脉的传播计算了断层摄影术( CT )和磁性的回声成像( MRI )调查结果决定劣等的静脉 cava ( IVC )的优异程度血栓和 IVC 墙侵略并且把他们与外科、病理学的报告作比较。从 1999 年 1 月的方法到 2007 年 8 月, 25 个病人与 IVC 结果血栓与 RCC 被诊断。在他们的操作前,所有病人有美国船,对比提高的 CT 和 MRI 发现结果血栓和 IVC 墙侵略的优异程度。所有 postprocessing 技术被富有经验的放射线学者执行。二个病理学家在所有病理标本上报导了。瘤血栓的优异程度被高级外科医生在每操作证实,用根据 2004 Mayo 诊所分类定义的血栓的层次。X 光线照相术的结果与所有病人有的外科、病理学的 findings.Results 相比激进的肾切除术和瘤血栓切除。八个病人在左边上有 RCC 并且 17 在右边上。根据临床、病理学的调查结果, 6 个病人有水平瘤血栓, 9 水平, 5 水平和 5 水平。六个病人让 IVC 围侵略。没有病人有淋巴节点或远转移的证据。25 个病人,美国船正确地在 18/25, CT 23/25 和 MR123/25 诊断了瘤血栓的优异程度。发现 IVC 墙侵略 preoperatively.Conclusions Multidectector 的 1 个盒子的美国船计算了断层摄影术和磁性的回声成像比在在肾的房间癌诊断劣等的静脉 cava 瘤血栓的腹的超声可比较、更有效。任何一个都不能三个方法检测劣等的静脉 cava 墙侵略。 | GUO Hong-feng SONG Yi NA Yan-qun | 2009 | Chinese Medical Journal2009，，19： | 11 |
| 11 | Numerical Simulation of Typhoon Muifa(2011) Using a Coupled Ocean-Atmosphere-Wave-Sediment Transport(COAWST) Modeling System显示文摘The newly developed Coupled Ocean-Atmosphere-Wave-Sediment Transport(COAWST) Modeling System is applied to investigate typhoon-ocean interactions in this study. The COAWST modeling system represents the state-of-the-art numerical simulation technique comprising several coupled models to study coastal and environmental processes. The modeling system is applied to simulate Typhoon Muifa(2011), which strengthened from a tropical storm to a super typhoon in the Northwestern Pacific, to explore the heat fluxes exchanged among the processes simulated using the atmosphere model WRF, ocean model ROMS and wave model SWAN. These three models adopted the same horizontal grid. Three numerical experiments with different coupling configurations are performed in order to investigate the impact of typhoon-ocean interaction on the intensity and ocean response to typhoon. The simulated typhoon tracks and intensities agree with observations. Comparisons of the simulated variables with available atmospheric and oceanic observations show the good performance of using the coupled modeling system for simulating the ocean and atmosphere processes during a typhoon event. The fully coupled simulation that includes a ocean model identifies a decreased SST as a result of the typhoon-forced entrainment. Typhoon intensity and wind speed are reduced due to the decrease of the sea surface temperature when using a coupled ocean model. The experiments with ocean coupled to atmosphere also results in decreased sea surface heat flux and air temperature. The heat flux decreases by about 29% compared to the WRF only case. The reduction of the energy induced by SST decreases, resulting in weakening of the typhoon. Coupling of the waves to the atmosphere and ocean model induces a slight increase of SST in the typhoon center area with the ocean-atmosphere interaction increased as a result of wave feedback to atmosphere. | LIU Na LING Tiejun WANG Hui ZHANG Yunfei GAO Zhiyi WANG Yi | 2015 | Journal of Ocean University of China2015，14，2： | 10 |
| 12 | A de novo Genome of a Chinese Radish Cultivar显示文摘Here, we report a high-quality draft genome of a Chinese radish(Raphanus sativus) cultivar. This draft contains 387.73 Mb of assembled scaffolds, 83.93% of the scaffolds were anchored onto nine pseudochromosomes and 95.09% of 43 240 protein-coding genes were functionally annotated. 184.75 Mb(47.65%) of repeat sequences was identified in the assembled genome. By comparative analyses of the radish genome against 10 other plant genomes, 2 275 genes in 780 gene families were found unique to R. sativus. This genome is a good reference for genomic study and of great value for genetic improvement of radish. | ZHANG Xiaohui YUE Zhen MEI Shiyong QIU Yang YANG Xinhua CHEN Xiaohua CHENG Feng WU Zhangyan SUN Yuyan JING Yi LIU Bo SHEN Di WANG Haiping CUI Na DUAN Yundan WU Jian WANG Jinglei GAN Caixia WANG Jun WANG Xiaowu LI Xixiang | 2015 | Horticultural Plant Journal2015，1，3： | 10 |
| 13 | Aluminum matrix composites reinforced by molybdenum-coated carbon nanotubes显示文摘To extend the application of carbon nanotubes (CNTs) and explore novel aluminum matrix composites,CNTs were coated by molybdenum layers using metal organic chemical vapor deposition,and then Mo-coated CNT (Mo-CNT)/Al composites were prepared by the combination processes of powder mixing and spark plasma sintering.The influences of powder mixing and Mo-CNT content on the mechanical properties and electrical conductivity of the composites were investigated.The results show that magnetic stirring is better than mechanical milling for mixing the Mo-CNTs and Al powders.The electrical conductivity of the composites decreases with increasing Mo-CNT content.When the Mo-CNT content is 0.5wt%,the tensile strength and hardness of Mo-CNT/Al reach their maximum values.The tensile strength of 0.5wt% Mo-CNT/Al increases by 29.9%,while the electrical conductivity only decreases by 7.1%,relative to sintered pure Al.The phase analysis of Mo-CNT/Al composites reveals that there is no formation of Al carbide in the composites. | Jun-hui Nie Cheng-chang Jia Na Shi Ya-feng Zhang Yi Li XianJia | 2011 | International Journal of Minerals,Metallurgy and Materials2011，18，6： | 9 |
| 14 | Training for percutaneous renal access on a virtual reality simulator显示文摘 | ZHANG Yi YU Cheng-fan LIU Jin-shun WANG Gang ZHU He NA Yan-qun | 2013 | Chinese Medical Journal2013，，8： | 9 |
| 15 | Triboelectric–Electromagnetic Hybrid Generator for Harvesting Blue Energy显示文摘Progress has been developed in harvesting lowfrequency and irregular blue energy using a triboelectric–electromagnetic hybrid generator in recent years. However,the design of the high-efficiency, mechanically durable hybrid structure is still challenging. In this study, we report a fully packaged triboelectric–electromagnetic hybrid generator(TEHG), in which magnets were utilized as the trigger to drive contact–separation-mode triboelectric nanogenerators(CS-TENGs) and coupled with copper coils to operate rotary freestanding-mode electromagnetic generators(RF-EMGs). The magnet pairs that produce attraction were used to transfer the external mechanical energy to the CS-TENGs, and packaging of the CS-TENGpart was achieved to protect it from the ambient environment. Under a rotatory speed of 100 rpm, the CS-TENGs enabled the TEHG to deliver an output voltage, current,and average power of 315.8 V, 44.6 μA, and ~ 90.7 μW,and the output of the RF-EMGs was 0.59 V, 1.78 m A, and 79.6 μW, respectively. The cylinder-like structure made the TEHG more easily driven by water flow and demonstrated to work as a practical power source to charge commercial capacitors. It can charge a 33μF capacitor from 0 to 2.1 V in 84 s, and the stored energy in the capacitor can drive an electronic thermometer and form a self-powered water-temperature sensing system. | Huiyun Shao Ping Cheng Ruixuan Chen Lingjie Xie Na Sun Qingqing Shen Xiaoping Chen Qianqian Zhu Yi Zhang Yina Liu Zhen Wen Xuhui Sun | 2018 | Nano-Micro Letters2018，10，3： | 9 |
| 16 | Chronic Intermittent Hypobaric Hypoxia Ameliorates Renal Vascular Hypertension Through Up-regulating NOS in Nucleus Tractus Solitarii显示文摘Chronic intermittent hypobaric hypoxia(CIHH)is known to have an anti-hypertensive effect, which might be related to modulation of the baroreflex in rats with renal vascular hypertension(RVH). In this study, RVH was induced by the 2-kidney-1-clip method(2 K1 C) in adult male Sprague-Dawley rats. The rats were then treated with hypobaric hypoxia simulating 5000 m altitude for 6 h/day for 28 days. The arterial blood pressure(ABP), heart rate(HR), and renal sympathetic nerve activity(RSNA) were measured before and after microinjection of L-arginine into the nucleus tractus solitarii(NTS) in anesthetized rats.Evoked excitatory postsynaptic currents(eEPSCs) and spontaneous EPSCs(sEPSCs) were recorded in anterogradely-labeled NTS neurons receiving baroreceptor afferents. We measured the protein expression of neuronal nitric oxide synthase(nNOS) and endothelial NOS(eNOS) in the NTS. The results showed that the ABP in RVH rats was significantly lower after CIHH treatment. The inhibition of ABP, HR, and RSNA induced by L-arginine was less in RVH rats than in sham rats, and greater in the CIHHtreated RVH rats than the untreated RVH rats. The eEPSC amplitude in NTS neurons receiving baroreceptor afferents was lower in the RVH rats than in the sham rats and recovered after CIHH. The protein expression of nNOS and e NOS in the NTS was lower in the RVH rats than in the sham rats and this decrease was reversed by CIHH. In short, CIHH treatment decreases ABP in RVH rats via upregulating NOS expression in the NTS. | Na Li Yue Guan Yan-Ming Tian Hui-Jie Ma Xiangjian Zhang Yi Zhang Sheng Wang | 2019 | Neuroscience Bulletin2019，35，1： | 9 |
| 17 | Efficient and Large-Scale Synthesis of Few-Layered Graphene Using an Arc-Discharge Method and Conductivity Studies of the Resulting Films显示文摘An arc-discharge method using a buffer gas containing carbon dioxide has been developed for the efficient and large-scale synthesis of few-layered graphene.The resulting samples of few-layered graphene,well-dispersed in organic solvents such as N,N-dimethylformamide(DMF)and 1,2-dichlorobenzene(o-DCB),were examined by transmission electron microscopy(TEM),X-ray diffraction(XRD),Raman spectroscopy,atomic force microscopy(AFM),and thermal gravimetric analysis(TGA).The electrical conductivity and transparency of flexible films prepared using a direct solution process have also been studied. | Yingpeng Wu Bin Wang Yanfeng Ma Yi Huang Na Li Fan Zhang Yongsheng Chen | 2010 | Nano Research2010，3，9： | 8 |
| 18 | Identifying Metabolite and Protein Biomarkers in Unstable Angina In-patients by Feature Selection Based Data Mining Method显示文摘Unstable angina(UA) is the most dangerous type of Coronary Heart Disease(CHD) to cause more and more mortal and morbid world wide. Identification of biomarkers for UA at the level of proteomics and metabolomics is a better avenue to understand the inner mechanism of it. Feature selection based data mining method is better suited to identify biomarkers of UA. In this study, we carried out clinical epidemiology to collect plasmas of UA in-patients and controls. Proteomics and metabolomics data were obtained via two-dimensional difference gel electrophoresis and gas chromatography techniques. We presented a novel computational strategy to select biomarkers as few as possible for UA in the two groups of data. Firstly, decision tree was used to select biomarkers for UA and 3-fold cross validation was used to evaluate computational performances for the three methods. Alternatively, we combined independent t test and classification based data mining method as well as backward elimination technique to select, as few as possible, protein and metabolite biomarkers with best classification performances. By the method, we selected 6 proteins and 5 metabolites for UA. The novel method presented here provides a better insight into the pathology of a disease. | SHI Cheng-he ZHAO Hui-hui HOU Na CHEN Jian-xin SHI Qi XU Xue-gong WANG Juan ZHENG Cheng-long ZHAO Ling-yan YANG Yi WANG Wei | 2011 | Chemical Research in Chinese Universities2011，27，1： | 8 |
| 19 | Repeatability and Reproducibility of Quantitative Assessment of the Retinal Microvasculature Using Optical Coherence Tomography Angiography Based on Optical Microangiography显示文摘Objective The aim of this study was to determine the repeatability and reproducibility of optical coherence tomography angiography(OCTA) based on optical microangiography(OMAG) measurements of macular vessels in normal eyes. Methods In this prospective cohort study, 40 eyes of 40 healthy volunteers underwent repeated OCTA(Cirrus HD-OCT 5000 angiography system, Carl Zeiss Meditec, Inc.) scans on two separate visit days. On each visit day, the eyes were scanned three times. The following parameters were used to quantitatively describe the OCTA images of the superficial vascular network: vessel area density(VAD), vessel skeleton density(VSD), vessel diameter index(VDI), vessel perimeter index(VPI), vessel complexity index(VCI), flux, and foveal avascular zone(FAZ). Coefficient of variation(CV) and intraclass correlation coefficient(ICC) were calculated for evaluating intravisit and intervisit repeatability, as well as interobserver reproducibility. Results The measurements showed high repeatability [CVs ≤ 4.2%(intravisit) and ≤ 4.6%(intervisit)] and interobserver reproducibility(ICCs ≥ 0.923) for all parameters. Conclusion This study demonstrated good repeatability and reproducibility of OCTA based on OMAG for the measurement of superficial vessel parameters in normal eyes. | ZHAO Qi YANG Wen Li WANG Xiao Na Ruikang K Wang YOU Qi Sheng CHU Zhong Di XIN Chen ZHANG Meng Yu LI Dong Jun WANG Zi Yang CHEN Wei LI Yi Feng CUI Rui SHEN Lin WEI Wen Bin | 2018 | Biomedical and Environmental Sciences2018，31，6： | 8 |
| 20 | Relationship between Maternal PBMC HBV cccDNA and HBV Serological Markers and its Effect on HBV Intrauterine Transmission显示文摘Objective To investigate the relationship between maternal peripheral blood mononuclear cells (PBMC) hepatitis B virus(HBV) covalenty closed circular deoxyribonucleic acid(cccDNA) and other HBV serological markers and its effects on HBV intrauterine transmission. Methods We enrolled 290 newborns and their hepatitis B surface antigen(HBsAg) positive mothers. HBV cccDNA in PBMC and HBV DNA in serum were detected by a real‐time PCR‐TaqM an probe while HBV serological markers were detected with an electrochemiluminescence immunoassay. Results There was a positive correlation between the levels of PBMC HBV cccD NA and serum HBV DNA and HBeA g(r = 0.436 and 0.403, P < 0.001). The detection rate of pattern A [‘HBsA g(+), HBeA g(+), and anti‐HBc(+)’] was significantly higher in the PBMC HBV cccD NA positive group than in the control group(χ^2 = 48.48, P < 0.001). There was a significant association between HBV intrauterine transmission and PBMC HBV cccD NA(χ^2 = 9.28, P = 0.002). In the presence of serum HBV DNA, HBeA g, and PBMC HBV cccD NA, the risk of HBV intrauterine transmission was three times higher(OR = 3.69, 95% CI: 1.30‐10.42) than that observed in their absence. The risk of HBV intrauterine transmission was the greatest(OR = 5.89, 95% CI: 2.35‐14.72) when both PBMC HBV cccD NA and pattern A were present. A Bayesian network model showed that maternal PBMC HBV cccD NA was directly related to HBV intrauterine transmission. Conclusion PBMC HBV cccDNA may be a direct risk factor for HBV intrauterine transmission. Our study suggests that serological markers could be combined with PBMC‐related markers in prenatal testing. | WANG Dan Dan YI Lin Zhu WU Li Na YANG Zhi Qing HAO Hai Yun SHI Xiao Hong WANG Bo FENG Shu Ying FENG Yong Liang WANG Su Ping | 2019 | Biomedical and Environmental Sciences2019，32，5： | 8 |
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