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| 1 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 2 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 3 | Simultaneous virus identification and characterization of severe unexplained pneumonia cases using a metagenomics sequencing technique显示文摘Many viruses can cause respiratory diseases in humans.Although great advances have been achieved in methods of diagnosis,it remains challenging to identify pathogens in unexplained pneumonia(UP) cases.In this study,we applied next-generation sequencing(NGS) technology and a metagenomic approach to detect and characterize respiratory viruses in UP cases from Guizhou Province,China.A total of 33 oropharyngeal swabs were obtained from hospitalized UP patients and subjected to NGS.An unbiased metagenomic analysis pipeline identified 13 virus species in 16 samples.Human rhinovirus C was the virus most frequently detected and was identified in seven samples.Human measles virus,adenovirus B 55 and coxsackievirus A10 were also identified.Metagenomic sequencing also provided virus genomic sequences,which enabled genotype characterization and phylogenetic analysis.For cases of multiple infection,metagenomic sequencing afforded information regarding the quantity of each virus in the sample,which could be used to evaluate each viruses' role in the disease.Our study highlights the potential of metagenomic sequencing for pathogen identification in UP cases. | Xiaohui Zou Guangpeng Tang Xiang Zhao Yan Huang Tao Chen Mingyu Lei Wenbing Chen Lei Yang Wenfei Zhu Li Zhuang Jing Yang Zhaomin Feng Dayan Wang Dingming Wang Yuelong Shu | 2017 | Science China(Life Sciences)2017，60，3： | 14 |
| 4 | Oxidized low-density lipoprotein activates adipophilin through ERK1/2 signal pathway in RAW264.7 cells显示文摘它被报导了那氧化低密度的脂蛋白(Ox-LDL ) 能增加 adipophilin 的表示。然而,详细机制充分没被理解。这研究的目的是在 adipophilin 表示和细胞内部的类脂化合物微滴累积上调查 Ox-LDL 的机制。一个鼠标像巨噬细胞的房间线, RAW264.7,全部被使用,并且 Ox-LDL 以一种剂量依赖者方式导致了 adipophilin 表示,这被发现。而且, Ox-LDL 导致了 peroxisome 激活 proliferator 的受体 --(PPAR ) 表示和 PPAR 特定的禁止者 T0070907 没废除 Ox-LDL-induced adipophilin 表示,而是特定的收缩筋 GW1929。而且, Ox-LDL 导致了 ERK1/2 的 phosphorylation,并且由 PD98059 的 ERK1/2-specific 抑制压制了 Ox-LDL-induced PPAR 和 adipophilin 表示。结果显示出那 ERK1/2 或 PPAR 特定的抑制减少了细胞内部的类脂化合物微滴的数量。同时, PPAR 特定的收缩筋增加了细胞内部的类脂化合物微滴。这些结果建议 Ox-LDL-induced 经由 ERK1/2 激活在 adipophilin 水平增加是在 RAW264.7 房间导致细胞内部的类脂化合物微滴的更大的数量的机制之一,它显示 adipophilin 涉及动脉粥样硬化患者前进。 | Qingnan Liu Zhibing Dai Zhiqiang Liu Xiaohui Liu Chaoke Tang Zuo Wang Guanghui Yi Lushan Liu Zhisheng Jiang Yongzong Yang Zhonghua Yuan | 2010 | Acta Biochimica et Biophysica Sinica2010，42，9： | 13 |
| 5 | rMVP: A Memory-efficient, Visualization-enhanced, and Parallel-accelerated Tool for Genome-wide Association Study显示文摘Along with the develoipment of high-throughput sequencing technologies,both sample size and SNP number are increasing rapidly in genome-wide association studies(GWAS),and the associated computation is more challenging than ever.Here,we present a memory-efficient,visualization-enhanced,and parallel-accelerated R package called“r MVP”to address the need for improved GWAS computation.r MVP can 1)effectively process large GWAS data,2)rapidly evaluate population structure,3)efficiently estimate variance components by Efficient Mixed-Model Association e Xpedited(EMMAX),Factored Spectrally Transformed Linear Mixed Models(Fa ST-LMM),and Haseman-Elston(HE)regression algorithms,4)implement parallel-accelerated association tests of markers using general linear model(GLM),mixed linear model(MLM),and fixed and random model circulating probability unification(Farm CPU)methods,5)compute fast with a globally efficient design in the GWAS processes,and 6)generate various visualizations of GWASrelated information.Accelerated by block matrix multiplication strategy and multiple threads,the association test methods embedded in r MVP are significantly faster than PLINK,GEMMA,and Farm CPU_pkg.r MVP is freely available at https://github.com/xiaolei-lab/r MVP. | Lilin Yin Haohao Zhang Zhenshuang Tang Jingya Xu Dong Yin Zhiwu Zhang Xiaohui Yuan Mengjin Zhu Shuhong Zhao Xinyun Li Xiaolei Liu | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 12 |
| 6 | High power triboelectric nanogenerator based on printed circuit board (PCB) technology显示文摘从我们的环境收获机械精力获得稳定、高的力量产量由于便携式的电子学的快开发吸引了集中的兴趣。在这个工作,组织磁盘的摩擦电 nanogenerator (TENG ) 基于成熟印刷电路板(聚氯联苯) 被准备为有效地在空间改进利用的技术和合成结构。在 CHS 作为的窗户和呆滞的修正,窗户 shading 设备和太阳的国内热水系统的 1e 采纳的一个狭窄的栅栏翻新措施。在这份报纸,焦点作为一项 retrofit 措施在 CHS 在用阶段变化材料(脉冲编码调制) 的热存储的采纳以后。结果显示那与融化 23 的温度使用脉冲编码调制 ? 訄吗?? | Changbao Han Chi Zhang Wei Tang Xiaohui Li Zhong Lin Wang | 2015 | Nano Research2015，8，3： | 10 |
| 7 | The long-term variability of sea surface temperature in the seas east of China in the past 40 a显示文摘The global surface temperature change since the mid-19th century has caused general concern and intensive study.However,long-term changes in the marginal seas,including the seas east of China,are not well understood because long-term observations are sparse and,even when they exist,they are over limited areas.Preliminary results on the long-term variability of sea surface temperature(SST) in summer and winter in the seas east of China during the period of 1957-2001 are reported using the Ocean Science Database of Institute of Oceanology,Chinese Academy of Sciences,the coastal hydrological station in situ and satellite data.The results show well-defined warming trends in the study area.However warming and cooling trends vary from decade to decade,with steady and rapid warming trends after the 1980s and complicated spatial patterns.The distribution of SST variation is intricate and more blurred in the areas far away from the Kuroshio system.Both historical and satellite data sets show significant warming trends after 1985.The warming trends are larger and spread to wider areas in winter than in summer,which means decrease in the seasonal cycle of SST probably linked with recently observed increase of the tropical zooplankton species in the region.Spatial structures of the SST trends are roughly consistent with the circulation pattern especially in winter when the meridional SST gradients are larger,suggesting that a horizontal advection may play an important role in the long-term SST variability in winter. | WANG Fan MENG Qingjia TANG Xiaohui HU Dunxin | 2013 | Acta Oceanologica Sinica2013，32，3： | 9 |
| 8 | Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis显示文摘最近的研究在嗅觉的薄板 propria 作为居民干细胞的一种新类型识别了嗅觉的 ecto 间充质的干细胞(OE-MSCs ) 。然而,它仍然保持不清楚是否 OE-MSCs 拥有任何 immunoregulatory 功能。在这研究,我们发现老鼠 OE-MSCs 比骨头表示了更高转变的生长因素贝它和 interleukin-10 层次导出髓的 MSC。在文化, OE-MSCs 经由直接压制受动器 T 房间增长并且增加规章的 T (Treg ) 房间扩大施加了他们的抑制免疫力的能力。在有导致骨胶原的关节炎的老鼠, OE-MSCs 的采纳转移显著地压制了关节炎发作和疾病严厉,它被增加的 Treg 房间伴随并且在 vivo 减少了 Th1/Th17 房间回答。一起拿,我们的调查结果在调整 T 房间回答识别了 OE-MSCs 的新奇功能,显示那 OE-MSCs 可以为风湿性关节炎和另外的自体免疫的疾病的处理代表新房间治疗。 | Ke Rui Zhijiang Zhang Jie Tian Xiang Lin Xiaohui Wang Jie Ma Xinyi Tang Huaxi Xu Liwei Lu Shengjun Wang | 2016 | Cellular & Molecular Immunology2016，13，3： | 8 |
| 9 | Dynamically controlling terahertz wavefronts with cascaded metasurfaces显示文摘Dynamically controlling terahertz(THz)wavefronts in a designable fashion is highly desired in practice.However,available methods working at microwave frequencies do not work well in the THz regime due to lacking suitable tunable elements with submicrometer sizes.Here,instead of locally controlling individual meta-atoms in a THz metasurface,we show that rotating different layers(each exhibiting a particular phase profile)in a cascaded metadevice at different speeds can dynamically change the effective Jonesmatrix property of the whole device,thus enabling extraordinary manipulations on the wavefront and polarization characteristics of a THz beam impinging on the device.After illustrating our strategy based on model calculations,we experimentally demonstrate two proof-of-concept metadevices,each consisting of two carefully designed all-silicon transmissive metasurfaces exhibiting different phase profiles.Rotating two metasurfaces inside the fabricated devices at different speeds,we experimentally demonstrate that the first metadevice can efficiently redirect a normally incident THz beam to scan over a wide solid-angle range,while the second one can dynamically manipulate both the wavefront and polarization of a THz beam.Our results pave the way to achieving dynamic control of THz beams,which is useful in many applications,such as THz radar,and bio-and chemical sensing and imaging. | Xiaodong Cai Rong Tang Haoyang Zhou Qiushi Li Shaojie Ma Dongyi Wang Tong Liu Xiaohui Ling Wei Tan Qiong He Shiyi Xiao Lei Zhou | 2021 | Advanced Photonics2021，3，3： | 8 |
| 10 | Tissue resident regulatory T cells: novel therapeutic targets for human disease显示文摘 | Xiaohui Zhou Jiayou Tang Hao Cao Huimin Fan Bin Li | 2015 | Cellular & Molecular Immunology2015，12，5： | 7 |
| 11 | Arbuscular Mycorrhizal Symbiosis Requires a Phosphate Transceptor in the Gigaspora margarita Fungal Symbiont显示文摘陆上的脉管的植物的多数能够形成 mutualistic 协会与要求 biotrophic arbuscular mycorrhizal (AM ) 从门 Glomeromycota 的真菌。这 mutualistic 共生提供糖类给真菌,并且相互地改进植物磷酸盐举起。AM 真菌的 transporters 能通过菌丝的网络从土壤获得磷酸盐。不过, AM 真菌的磷酸盐 transporters 的精确函数,并且他们是否充当传感器或作为滋养的 transporters,在真菌的信号 transduction 仍然保持不清楚。这里,我们从为 AM 共生被要求的 Gigaspora margarita 报导高亲密关系的磷酸盐 transporter GigmPT。GigmPT 的导致主人的基因 silencing 妨碍 G 的发展。margarita 在 AM 期间共生。最重要地, GigmPT 在 G 作为磷酸盐 transceptor 工作。关于表明小径以及蛋白质的磷酸盐的激活的 margarita kinase A 发信号串联。用代用品半胱氨酸可接近性方法,我们识别了残余 A 146( 在 transmembrane 领域[TMD ] IV ) 并且瓦尔 357( 在 TMD VIII ) GigmPT,哪个为磷酸盐在生长期间在酵母发信号和运输是批评的感应。一起,我们的结果从 AM 真菌 G 提供重要卓见进磷酸盐 transceptor 的分子的功能。margarita。 | Xianan Xie Hui Lin Xiaowei Peng Congrui Xu Zhongfeng Sun Kexin Jiang Antian Huang Xiaohui Wu Nianwu Tang Alessandra Salvioli Paola Bonfante Bin Zhao | 2016 | Molecular Plant2016，9，12： | 6 |
| 12 | OxLDL up-regulates Niemann-Pick type C1 expression through ERK1/2/COX-2/ PPARα-signaling pathway in macrophages显示文摘NiemannPick 类型 C1 (NPC1 ) 主要位于迟了的 endosome/lysosome 的膜并且从迟了的 endosome/lysosome 控制细胞内部的胆固醇 trafficking 到血浆膜。它被报导了那氧化低密度的脂蛋白(oxLDL ) 罐头起来调整 NPC1 表情。然而,详细机制充分没被理解。在这研究,我们在 THP-1 巨噬细胞在 NPC1 表示上调查了 oxLDL 刺激的效果。我们的结果显示出在 mRNA 和蛋白质的起来调整的 NPC1 表示在一个剂量依赖者和时间依赖者举止铺平的那 oxLDL。另外, oxLDL 也导致了细胞外的调整信号的 kinase 1/2 (ERK1/2 ) 的 phosphorylation。有 oxLDL 的处理显著地在巨噬细胞增加了 cyclooxygenase-2 (COX-2 ) mRNA 和蛋白质表示,并且这些增加被 ERK1/2 禁止者 PD98059 或 ERK1/2 压制小介入 RNA (siRNA ) 处理。OxLDL 起来调整在 mRNA 和蛋白质的激活 proliferator 的受体(PPAR ) 铺平的 peroxisome 的表示,它能被 COX-2 siRNA 或 COX-2 禁止者 NS398 处理在这些巨噬细胞废除。OxLDL 戏剧性地提高了细胞的胆固醇流出,它被禁止 ERK1/2 或 COX-2 废除。另外,导致 oxLDL 的 NPC1 表示和细胞的胆固醇流出被 PPAR siRNA 或 GW6471 颠倒, PPAR 的一个对手。一起拿,这些结果提供证据那 oxLDL 罐头起来调整通过在巨噬细胞的 ERK1/2/COX-2/PPAR-signaling 小径的 NPC1 的表示。 | Xiaohua Yu Xiaoxu Li Guojun Zhao Ji Xiao Zhongcheng Mo Kai Yin Zhisheng Jiang Yuchang Fu Xiaohui Zha Chaoke Tang | 2012 | Acta Biochimica et Biophysica Sinica2012，44，2： | 6 |
| 13 | 基于智能脉诊仪的“人与天地相参”研究显示文摘目的探讨脉象与'人与天地相参'理论的相关性及其重现性。方法于2012年7月22日(大暑)至2014年6月21日(夏至)、2016年10月23日(霜降)至2018年10月23日(霜降)分别进行二轮实验观察,第一轮观察对象42人,第二轮50人,均为中国中医科学院在职职工、在读研究生。基于动态标准化脉诊信息采集和分析技术,采集受试者双手寸、关、尺的脉诊信息,同时记录当日最高气温、最低气温、日出时间、日落时间、昼时长、夜时长天地背景数据。采用余弦函数谐波拟合脉图建模方法获取脉图参数,通过两轮次脉学实验观察,从脉图参数角度分析脉位、脉力与天地参数的相关性与重现性。结果在193个参数中,脉位、脉力是跟随天地参数(太阳角度、气温)变化最明显的两个参数。脉位、脉力在两轮次实验中均伴随太阳角度呈现规律性和重现性。两轮次实验的脉位、脉力与太阳角度具有强相关性或中等相关性。结论脉位、脉力呈现出'人与天地相参'的规律,且具有重现性。 | 闪增郁 张喜 党娇娇 陈燕萍 逯波 张美玉 JPRaskin Xiaohui Tang 宋军 | 2019 | 中医杂志2019，60，24： | 5 |
| 14 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 15 | Parallel selection of distinct Tof5 alleles drove the adaptation of cultivated and wild soybean to high latitudes显示文摘Photoperiod responsiveness is a key factor limiting the geographic distribution of cultivated soybean and its wild ancestor.In particular,the genetic basis of the adaptation in wild soybean remains poorly understood.In this study,by combining whole-genome resequencing and genome-wide association studies we identified a novel locus,Time of Flowering 5(Tof5),which promotes flowering and enhances adaptation to high latitudes in both wild and cultivated soybean.By genomic,genetic and transgenic analyses we showed that Tof5 en-codes a homolog of Arabidopsis thaliana FRUITFULL(FUL).Importantly,further analyses suggested that different alleles of Tof5 have undergone parallel selection.The Tof5H1 allele was strongly selected by humans after the early domestication of cultivated soybean,while Tof5H2 allele was naturally selected in wild soybean,and in each case facilitating adaptation to high latitudes.Moreover,we found that the key flowering repressor E1 suppresses the transcription of Tof5 by binding to its promoter.In turn,Tof5 physically associates with the promoters of two important FLOWERING LOCUS T(FT),FT2a and FT5a,to upregulate their transcription and promote flowering under long photoperiods.Collectively,ourfindings provide insights into how wild soybean adapted to high latitudes through natural selection and indicate that cultivated soybean underwent changes in the same gene but evolved a distinct allele that was artificially selected after domestication. | Lidong Dong Qun Cheng Chao Fang Lingping Kong Hui Yang Zhihong Hou Yongli Li Haiyang Nan Yuhang Zhang Qingshan Chen Chunbao Zhang Kun Kou Tong Su Lingshuang Wang Shichen Li Haiyang Li Xiaoya Lin Yang Tang Xiaohui Zhao Sijia Lu Baohui Liu Fanjiang Kong | 2022 | Molecular Plant2022，15，2： | 5 |
| 16 | Thyristor Junction Temperature Estimation Based on Measured Temperature of Molybdenum Flat显示文摘为获得较准确的晶闸管结温,提出了基于晶闸管钼层实测温度计算结温的共扼梯度算法。分析了共轭梯度法用于求解结温的具体步骤,并通过FORTRAN语言编译形成LOG命令流,导入ANSYS软件中来实现算法,该方法对于未知的低频分量,以较少的迭代次数即可以得到准确解,对于未知的高频分量,通过多次的迭代也能够获得准确的返溯值,因而具备处理多个未知量且收敛速度快的优点。以KPD3000-72型晶闸管应用于直流输电领域为例,分别在直流稳态、单波次浪涌电流和3波次浪涌电流的试验条件下进行计算,结果表明所得结温准确,为传统热阻抗法提供了校核的依据。 | ZHANG Chunyu LI Chengrong HAN Xiaohui ZHA Kunpeng TANG Guangfu | 2012 | 中国电机工程学报2012，32，22： | 5 |
| 17 | Issues and rational design of aqueous electrolyte for Zn-ion batteries显示文摘Aqueous Zn-ion batteries(AZIBs)are regarded as a promising alternative to the widely used lithium-ion batteries in large-scale energy storage systems.The researches on the development of novel aqueous electrolyte to improve battery performance have also attracted great interest since the electrolyte is a key com-ponent for Zn2+migration between cathode and anode.Herein,we briefly sum-marized and illuminated the recent development tendency of aqueous electrolyte for AZIBs,then deeply analyzed its existing issues(water decomposition,cathode dissolution,corrosion and passivation,and dendrite growth)and discussed the corresponding optimization strategies(pH regulation,concentrated salt solution,electrolyte composition design,and functional additives).The internal mecha-nisms of these strategies were further revealed and the relationships between issues and solutions were clarified,which could guide the future development of aqueous electrolytes for AZIBs. | Qi Zhang Zefang Yang Huimin Ji Xiaohui Zeng Yougen Tang Dan Sun Haiyan Wang | 2021 | SusMat2021，1，3： | 3 |
| 18 | Syntenic quantitative trait loci and genomic divergence for Sclerotinia resistance and ?owering time in Brassica napus显示文摘Oilseed rape(Brassica napus) is an allotetraploid with two subgenomes descended from a common ancestor. Accordingly, its genome contains syntenic regions with many duplicate genes, some of which may have retained their original functions, whereas others may have diverged. Here, we mapped quantitative trait loci(QTL) for stem rot resistance(SRR), a disease caused by the fungus Sclerotinia sclerotiorum, and flowering time(FT) in a recombinant inbred line population. The population was genotyped using B.napus 60 K single nucleotide polymorphism arrays and phenotyped in six(FT) and nine(SSR) experimental conditions or environments. In total, we detected 30 SRR QTL and 22 FT QTL and show that some of the major QTL associated with these two traits were co-localized,suggesting a genetic linkage between them. Two SRR QTL on chromosome A2 and two on chromosome C2 were shown to be syntenic, suggesting the functional conservation of these regions. We used the syntenic properties of the genomic regions to exclude genes for selection candidates responsible for QTL-associated traits. For example, 152 of the 185 genes could be excluded from a syntenic A2–C2 region. These findings will help to elucidate polyploid genomics in future studies, in addition to providing useful information for B. napus breeding programs. | Fengqi Zhang Junyan Huang Minqiang Tang Xiaohui Cheng Yueying Liu Chaobo Tong Jingyin Yu Tehrim Sadia Caihua Dong Lingyan Liu Baojun Tang Jianguo Chen Shengyi Liu | 2019 | Journal of Integrative Plant Biology2019，61，1： | 3 |
| 19 | Comparison of the clinical outcomes of hematologic malignancies after myeloablative haploidentical transplantation with G-CSF/ATG and posttransplant cyclophosphamide:results from the Chinese Bone Marrow Transplantation Registry Group(CBMTRG)显示文摘This study compared G-CSF/ATG and PTCy in myeloablative haploidentical hematopoietic stem cell transplantation(haploHSCT)for hematologic malignancies between January 2013 and March 2018 reporting to the Chinese Bone Marrow Transplantation Registry Group(CBMTRG).For each PTCy,G-CSF/ATG subjects(1:4)were selected using the nested case-pair method.In total,220 patients including 176 in G-CSF/ATG group and 44 in PTCy group were analyzed.The incidences of 30-day neutrophil engraftment(88.6%vs.96.6%,P=0.001),90-day platelet engraftment(84.1%vs.94.2%,P=0.04),the median time to neutrophil engraftment(17 days vs.12 days,P=0.000)and platelet engraftment(22 days vs.17 days,P=0.001)were significantly inferior in PTCy group.The incidences of grades 2–4 and 3–4 acute graft-versus-host disease(GVHD),chronic GVHD and severe chronic GVHD were comparable.Among G-CSF/ATG and PTCy groups,the 3-year progression-free survival,overall survival,cumulative incidences of nonrelapse mortality and relapse was 74.3%vs.61%(P=0.045),78.3%vs.65.2%(P=0.039),12%vs.27.3%(P=0.008),and 14.9%vs.11.7%(P=0.61),respectively.G-CSF/ATG can achieve better engraftment,PFS and OS,and lower incidence of NRM compared to PTCy in myeloablative haplo-HSCT for hematologic malignancies. | Feifei Tang Yajing Xu Huiren Chen Lanping Xu Xiaohui Zhang Yu Wang Qifa Liu Depei Wu Xiaojun Huang | 2020 | Science China(Life Sciences)2020，63，4： | 3 |
| 20 | The Silurian A-Type Granites in Northeastern Guangxi,South China Block:New Evidence of Transition from Compression to Post-orogenic Extension of the Kwangsian Orogen显示文摘Objective More and more evidence suggests that the Kwangsian orogen is probably an intraplate orogen,which is one of the few examples of intraplate orogenesis worldwide.However,the initiation time,size and scope of the Kwangsian orogeny have not been determined yet.This study analyzed the Silurian A-type granites in | JIA Xiaohui WANG Xiaodi TANG Gongjian YANG Wenqiang NIU Zhijun | 2016 | Acta Geologica Sinica(English Edition)2016，90，5： | 3 |
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