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| 1 | Online monitoring of water-soluble ionic composition of PM_(10)during early summer over Lanzhou City显示文摘Lanzhou is one of the most aerosol-polluted cities in China. In this study, an online analyzer for Monitoring for AeRosols and GAses was deployed to measure major water-soluble inorganic ions in PM10 at 1-hour time resolution, and 923 samples were obtained from Apr 1 to May 24, 2011. During the field campaign, air pollution days were encountered with Air Quality Index more than 100 and daily average concentration of PM10 exceeding 150 μg/m3. Based on the variation of water-soluble ions and results of Positive Matrix Factorization 3.0 model execution, the air pollution days were classified as crustal species- or secondary aerosol-induced, and the different formation mechanisms of these two air pollution types were studied. During the crustal species pollution days, the content of Ca2+increased and was about 2.3 times higher than the average on clear days, and the air parcel back trajectory was used to analyze the sources of crustal species. Data on sulfate, trace gases and meteorological factors were used to reveal the formation mechanism of secondary aerosol pollution. The sulfur oxidation ratio(SOR) was derived from the 923 samples, and the SOR had high positive correlation with relative humidity in early summer in Lanzhou. | Jin Fan Xiaoying Yue Yi Jing Qiang Chen Shigong Wang | 2014 | Journal of Environmental Sciences2014，26，2： | 8 |
| 2 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 3 | Evaluation of four final irrigation protocols for cleaning root canal walls显示文摘The aim of this study was to compare the efficiency of four final irrigation protocols in smear layer removal and bacterial inhibition in root canal systems.Thirty roots inoculated with Enterococcus faecalis were prepared with ProTaper Universal files.The teeth were disinfected by conventional needle irrigation,sonic agitation using the EndoActivator device,passive ultrasonic irrigation,or an M3 Max file.Teeth with no root canal preparation served as blank controls for the establishment of the infection baseline.Teeth with preparation but no final irrigation served as a post-instrumentation baseline.After the final irrigation,the teeth were sectioned in half.One half of each tooth was examined by scanning electron microscopy(SEM)to assess smear layer removal using a five-point scale.The other half was examined by confocal laser scanning microscopy(CLSM)using the LIVE/DEAD BackLight bacterial viability kit to evaluate the depth of bacterial survival in dentinal tubules.SEM analysis revealed no significant difference in smear layer removal throughout the whole canal among the EA,PUI,and M3 Max groups(P>0.05).CLSM revealed that PUI achieved the greatest bacterial inhibition depth in the coronal((174.27±31.63)μm),middle((160.94±37.77)μm),and apical((119.53±28.49)μm)thirds of the canal(all P<0.05 vs.other groups).According to this comprehensive SEM and CLSM evaluation,PUI appears to have the best infection control ability in root canal systems. | Qiang Li Qian Zhang Xiaoying Zou Lin Yue | 2020 | International Journal of Oral Science2020，12，3： | 6 |
| 4 | Standardized Operational Protocol for Human Brain Banking in China显示文摘With the progress of society, there is an increasing need to tackle disorders of the central nervous system. Human brain tissue, unlike animal tissues, is an irreplaceable resource for the study of neurological diseases (1)Aimed at scientific research and education, the roles of human brain tissue repositories are to acquire brain tissue from donors, prepare, process, and preserve collected samples,provide tissue to specific eligible facilities, and determine the characteristics of each tissue sample. | Wenying Qiu Hanlin Zhang Aimin Bao Keqing Zhu Yue Huang Xiaoxin Yan Jing Zhang Chunjiu Zhong Yong Shen Jiangning Zhou Xiaoying Zheng Liwei Zhang Yousheng Shu Beisha Tang Zhenxin Zhang Gang Wang Ren Zhou Bing Sun Changlin Gong Shumin Duan Chao Ma | 2019 | Neuroscience Bulletin2019，35，2： | 6 |
| 5 | Expert consensus on regenerative endodontic procedures显示文摘Regenerative endodontic procedures(REPs)is a biologic-based treatment modality for immature permanent teeth diagnosed with pulp necrosis.The ultimate objective of REPs is to regenerate the pulp-dentin complex,extend the tooth longevity and restore the normal function.Scientific evidence has demonstrated the efficacy of REPs in promotion of root development through case reports,case series,cohort studies,and randomized controlled studies.However,variations in clinical protocols for REPs exist due to the empirical nature of the original protocols and rapid advancements in the research field of regenerative endodontics.The heterogeneity in protocols may cause confusion among dental practitioners,thus guidelines and considerations of REPs should be explicated.This expert consensus mainly discusses the biological foundation,the available clinical protocols and current status of REPs in treating immature teeth with pulp necrosis,as well as the main complications of this treatment,aiming at refining the clinical management of REPs in accordance with the progress of basic researches and clinical studies,suggesting REPs may become a more consistently evidence-based option in dental treatment. | Xi Wei Maobin Yang Lin Yue Dingming Huang Xuedong Zhou Xiaoyan Wang Qi Zhang Lihong Qiu Zhengwei Huang Hanguo Wang Liuyan Meng Hong Li Wenxia Chen Xiaoying Zou Junqi Ling | 2022 | International Journal of Oral Science2022，14，4： | 5 |
| 6 | 60-year changes and mechanisms of Urumqi Glacier No.1 in the eastern Tianshan of China,Central Asia显示文摘Worldwide examination of glacier change is based on detailed observations from only a small number of glaciers.The ground-based detailed individual glacier monitoring is of strong need and extremely important in both regional and global scales.A long-term integrated multi-level monitoring has been carried out on Urumqi Glacier No.1(UG1)at the headwaters of the Urumqi River in the eastern Tianshan Mountains of Central Asia since 1959 by the Tianshan Glaciological Station,Chinese Acamedey of Sciences(CAS),and the glaciological datasets promise to be the best in China.The boundaries of all glacier zones moved up,resulting in a shrunk accumulation area.The stratigraphy features of the snowpack on the glacier were found to be significantly altered by climate warming.Mass balances of UG1 show accelerated mass loss since 1960,which were attributed to three mechanisms.The glacier has been contracting at an accelerated rate since 1962,resulting in a total reduction of 0.37 km2 or 19.3%from 1962 to 2018.Glacier runoff measured at the UG1 hydrometeorological station demonstrates a significant increase from 1959 to 2018 with a large interannual fluctuation,which is inversely correlated with the glacier's mass balance.This study analyzes on the changes in glacier zones,mass balance,area and length,and streamflow in the nival glacial catchment over the past 60 years.It provides critical insight into the processes and mechanisms of glacier recession in response to climate change.The results are not only representative of those glaciers in the Tianshan mountains,but also for the continental-type throughout the world.The direct observation data form an essential basis for evaluating mountain glacier changes and the impact of glacier shrinkage on water resources in the interior drainage rivers within the vast arid and semi-arid land in northwestern China as well as Central Asia. | ZhongQin Li HuiLin Li ChunHai Xu YuFeng Jia FeiTeng Wang PuYu Wang XiaoYing Yue | 2020 | Research in Cold and Arid Regions2020，12，6： | 2 |
| 7 | Salivary protease spectrum biomarkers of oral cancer显示文摘Proteases are important molecules that are involved in many physiological and pathological processes of the human body,such as growth,apoptosis and metastasis cancer cells.They are potential targets in cancer diagnosis and biotherapy.In this study,we analyzed the salivary protease spectrum of patients with oral squamous cell carcinoma (OSCC),oral benign masses and chronic periodontitis,as well as that of health,using human protease array kits,enzyme-linked immunosorbent assay,western blot and immunofluorescence.The salivary protease spectrum was found to be associated with oral diseases.For example,the saliva of patients with OSCC contained increased numbers of proteases than those of other oral diseases and health.The levels of matrix metalloproteinase (MMP)-1,MMP-2,MMP-10,MMP-12,A disintegrin and metalloprotease (ADAM)9,A disintegrin and metalloprotease with thrombospondin type 13 motifs (ADAMST13),cathepsin V and kallikrein 5 in the saliva of patients with OSCC were significantly increased compared with those of other groups.Taking MMP-1,cathepsin V,kallikrein 5 and ADAM9 as biomarkers of OSCC,cutoff values were199,11.34,9.29 and 202.55 pg·mL?1,respectively.From the area under the curve,sensitivity and specificity,the combination of cathepsin V/kallikrein5/ADAM9 was an optimal biomarker for diagnosing OSCC.Thus,analysis of the salivary protease spectrum may be an innovative and cost-efficient approach to evaluating the health status of the oral cavity.Specifically,increases in cathepsin V,kallikrein 5 and ADAM9 may be useful biomarkers in the screening and diagnosis of OSCC. | Yun Feng Qian Li Jiao Chen Ping Yi Xin Xu Yaping Fan Bomiao Cui Yu Yu Xiaoying Li Yue Du Qianming Chen Lingling Zhang Jingjing Jiang Xuedong Zhou Ping Zhang | 2019 | International Journal of Oral Science2019，11，2： | 2 |
| 8 | Case study of dust event sources from the Gobi and Taklamakan deserts:An investigation of the horizontal evolution and topographical effect using numerical modeling and remote sensing显示文摘A severe dust event occurred from April 23 to April 27, 2014, in East Asia. A state-of-the-art online atmospheric chemistry model, WRF/Chem, was combined with a dust model, GOCART,to better understand the entire process of this event. The natural color images and aerosol optical depth(AOD) over the dust source region are derived from datasets of moderate resolution imaging spectroradiometer(MODIS) loaded on a NASA Aqua satellite to trace the dust variation and to verify the model results. Several meteorological conditions, such as pressure, temperature, wind vectors and relative humidity, are used to analyze meteorological dynamic. The results suggest that the dust emission occurred only on April 23 and 24,although this event lasted for 5 days. The Gobi Desert was the main source for this event,and the Taklamakan Desert played no important role. This study also suggested that the landform of the source region could remarkably interfere with a dust event. The Tarim Basin has a topographical effect as a 'dust reservoir' and can store unsettled dust, which can be released again as a second source, making a dust event longer and heavier. | Jin Fan Xiaoying Yue Qinghua Sun Shigong Wang | 2017 | Journal of Environmental Sciences2017，29，6： | 2 |
| 9 | High Temperature Decomposition Behavior of CaZrO3 Coating on Graphite for TiNi Alloy Melting显示文摘In order to restrain the carbon pollution, the feasibility of CaZrO3 coating was studied. The precursor powder was synthesized via solid-state reaction using metal calcium as a raw material. The protective coating on graphite was prepared by impregnation sintering method, and the effects of slurry viscosity, graphite density and coating thickness for coating were compared. The phase composition and microstructure of coatings were characterized, and the thermodynamic process was analyzed when the coating composition changed from CaZrO3 to ZrC. The results show that vacuum sintering can result in the decomposition of CaZrO3 and an intact ZrC coating with beautiful porous structure can be obtained. | 詹斌 ZHANG Yue WANG Caifen WANG Xiaoying | 2020 | Journal of Wuhan University of Technology(Materials Science)2020，35，5： | 1 |
| 10 | Spatiotemporal dynamics of ecosystem fires and biomass burning-induced carbon emissions in China over the past two decades显示文摘Fire is a major type of disturbance that has important influences on ecosystem dynamics and carbon cycles.Yet our understanding of ecosystem fires and their carbon cycle consequences is still limited,largely due to the difficulty of large-scale fire monitoring and the complex interactions between fire,vegetation,climate,and anthropogenic factors.Here,using data from satellite-derived fire observations and ecosystem model simulations,we performed a comprehensive investigation of the spatial and temporal dynamics of China’s ecosystem fire disturbances and their carbon emissions over the past two decades(1997–2016).Satellite-derived results showed that on average about 3.47-4.53×10^(4) km^(2) of the land was burned annually during the past two decades,among which annual burned forest area was about 0.81-1.25×10^(4) km^(2),accounting for 0.33-0.51%of the forest area in China.Biomass burning emitted about 23.02 TgC per year.Compared to satellite products,simulations from the Energy Exascale Earth System Land Model(ELM)strongly overestimated China’s burned area and fire-induced carbon emissions.Annual burned area and fire-induced carbon emissions were high for boreal forest in Northeast China’s Daxing’anling region and subtropical dry forest in South Yunnan,as revealed by both the satellite product and the model simulations.Our results suggest that climate and anthropogenic factors play critical roles in controlling the spatial and seasonal distribution of China’s ecosystem fire disturbances.Our findings highlight the importance of multiple complementary approaches in assessing ecosystem fire disturbance and its carbon consequences.Further studies are required to improve the methods of observing and modelling China’s ecosystem fire disturbances,which will provide valuable information for fire management and ecosystem sustainability in an era when both human activities and the natural environment are rapidly changing. | Anping Chen Rongyun Tang Jiafu Mao Chao Yue Xiran Li Mengdi Gao Xiaoying Shi Mingzhou Jin Daniel Ricciuto Sam Rabin Phillippe Ciais Shilong Piao | 2020 | Geography and Sustainability2020，1，1： | 1 |
| 11 | Potential Treatment of COVID-19 with Traditional Chinese Medicine: What Herbs Can Help Win the Battle with SARS-CoV-2?显示文摘Traditional Chinese medicine(TCM)has been successfully applied worldwide in the treatment of coronavirus disease 2019(COVID-19),which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).However,the pharmacological mechanisms underlying this success remain unclear.Hence,the aim of this review is to combine pharmacological assays based on the theory of TCM in order to elucidate the potential signaling pathways,targets,active compounds,and formulas of herbs that are involved in the TCM treatment of COVID-19,which exhibits combatting viral infections,immune regulation,and amelioration of lung injury and fibrosis.Extensive reports on target screening are elucidated using virtual prediction via docking analysis or network pharmacology based on existing data.The results of these reports indicate that an intricate regulatory mechanism is involved in the pathogenesis of COVID-19.Therefore,more pharmacological research on the natural herbs used in TCM should be conducted in order to determine the association between TCM and COVID-19 and account for the observed therapeutic effects of TCM against COVID-19. | Lin Li Yuzheng Wu Jiabao Wang Huimin Yan Jia Lu Yu Wang Boli Zhang Junhua Zhang Jian Yang Xiaoying Wang Min Zhang Yue Li Lin Miao Han Zhang | 2022 | Engineering2022，，12： | 1 |
| 12 | Computation of wind-structure interaction on tension structure显示文摘 | Yue Wu Xiaoying Sun Shizhao Shen | 2008 | Journal of Wind Engineering and Industrial Aerodynamics2008，96，： | 1 |
| 13 | Stereo matching algorithms with different cost aggregation显示文摘 | NingKelin Zhang Xiaoying Ming Yue | 2014 | Proceedings of International Conference on Computer Science and Information Technology2014，，1： | 1 |
| 14 | Partition-coordinated control of soil and water loss for chestnut forests in the Yanshan Mountain Region, China显示文摘Soil erosion from chestnut forests is one of the most important factors causing land degradation in the Yanshan Mountain Region. A 2-year field study was done to compare the effects on erosion of a control plot(CP), a repaired and maintained horizontal ditch built with an engineering baffle every 6 m(MP 1),and a repaired and maintained horizontal ditch built with an engineering baffle every 8 m(MP 2). The results showed that the slope runoff of chestnut forests was influenced by rainfall characteristic factors.No single rainfall characteristic factor showed dominance for hill slope runoff. The runoff reduction effect of the partition-coordinated erosion control measures(MP 1 and MP 2) was substantial for chestnut forests under high rainfall intensity conditions. However, the runoff reduction efficiency was higher under the conditions of heavy rainfall and low average rainfall intensity than for storms with higher intensity and lower total rainfall. The reduction effect of the partition-coordinated erosion control measures on the runoff and sediment yield of chestnut forest slopes was MP 2 > MP 1 > CP. The runoff reduction rate and erosion reduction rate of MP 2 reached 61.70% and 97.41%, respectively, and that for MP 1 was 54.15% and 85.31%, respectively. Therefore, after a comprehensive comparison, MP 2 was determined to be more effective for soil erosion control for a sloping chestnut forest. | Xinhui Ding Guangquan Liu Xiaoying Liu Yongsheng Xie Zhichun Yue | 2019 | International Journal of Sediment Research2019，34，1： | 1 |
| 15 | Computation of wind-structure interaction on tension structures 显示文摘 | Wu Yue Sun Xiaoying Shen Shizhao | 2008 | Journal of Wind Engineering and Industrial Aerodynamics2008，96，1011： | 1 |
| 16 | Involvement of Notch signal- ling pathway in senescence of human dental pulp cells显示文摘 | Xiaoying Z Heng Z Yue L | 2010 | Chin J Dent Res2010，13，1： | 1 |
| 17 | Reproducing kernel triangular B-spline-based FEM for solving PDEs显示文摘 | Yue Jia Yongjie Zhang Gang Xu Xiaoying Zhuang Timon Rabczuk | 2013 | Computer Methods in Applied Mechanics and Engineering2013，，： | 1 |
| 18 | Enhancer RNAs: A missing regulatory layer in gene transcription显示文摘Enhancers and super-enhancers exert indispensable roles in maintaining cell identity through spatiotemporally regulating gene transcription.Meanwhile,active enhancers and super-enhancers also produce transcripts termed enhancer RNAs(eRNAs) from their DNA elements.Although enhancers have been identified for more than 30 years,widespread transcription from enhancers are just discovered by genome-wide sequencing and considered as the key to understand longstanding questions in gene transcription.RNA-transcribed enhancers are marked by histone modifications such as H3K4m1/2 and H3K27Ac,and enriched with transcription regulatory factors such as LDTFs,P300,CBP,BRD4 and MED1.Those regulatory factors might constitute a Mega-Trans-like complex to potently activate enhancers.Compared to mRNAs,eRNAs are quite unstable and play roles at local.Functionally,it has been shown that e RNAs promote formation of enhancer-promoter loops.Several studies also demonstrated that eRNAs help the binding of RNA polymerase II(RNAPII) or transition of paused RNAPII by de-association of the negative elongation factor(NELF) complex.Nevertheless,these proposed mechanisms are not universally accepted and still under controversy.Here,we comprehensively summarize the reported findings and make perspectives for future exploration.We also believe that super-enhancer derived RNAs(seRNAs) might be informative to understand the nature of super-enhancers. | Renfang Mao Yuanyuan Wu Yue Ming Yuanpei Xu Shouyan Wang Xia Chen Xiaoying Wang Yihui Fan | 2019 | Science China(Life Sciences)2019，62，7： | 1 |
| 19 | Computation of wind-structure interaction on tension structures显示文摘 | Wu Yue Sun Xiaoying Shen Shizhao | 2008 | Journal of Wind Engineering and Industrial Aerodynamics2008，96，1011： | 1 |
| 20 | The ability of cone-beam computerized tomography to detect vertical root fractures in endodontically treated and nonendodontically treated teeth: a report of 3 cases显示文摘 | Xiaoying Zou Denggao Liu Lin Yue Minkai Wu | 2011 | Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology2011，，： | 1 |
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