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| 1 | Fine mapping of the awn gene on chromosome 4 in rice by association and linkage analyses显示文摘Awnness is a key trait in rice domestication, yet no studies have been conducted on fine mapping or association mapping of the rice awn gene. In this study, we investigated the awnness and genotype of a core collection of 303 cultivated rice varieties and a BC5F2 segregating population of 200 individuals. Combining association and linkage analyses, we mapped the awnness related genes to chromosome 4. Primary association analysis using 24 SSR markers revealed five loci significantly associated with awnness on chromosome 4. The associated markers cover previously identified regions. Fine association mapping was conducted using another 29 markers within a 4-Mb region, covering the associated marker in34, which is close to the awn gene Awn4.1. Seven associated markers were revealed, distributed over an 870-kb region. Combining the fine association mapping and linkage analysis of awnness in the 200 BC5F2 segregating population, we finally identified a 330-kb region as the candidate region for Awn4.1. The results indicate that combining association mapping and linkage mapping provides an efficient and precise approach to both genome-wide mapping and fine mapping of rice genes. | HU GuangLong ZHANG DongLing PAN HuiQiao LI Ben WU JianTao ZHOU XueYa ZHANG QunYuan ZHOU Lei YAO GuoXin LI JunZhou LI JinJie ZHANG HongLiang LI ZiChao | 2011 | Chinese Science Bulletin2011，56，9： | 4 |
| 2 | Development of upland rice introgression lines and identification of QTLs for basal root thickness under different water regimes显示文摘基因渗入线(IL ) 是为识别量的特点 loci (QTL ) 的珍贵材料,评估帮助的基因相互作用,和标记繁殖。包含的一套 430 IL (BC5F3 ) 在一块低地从高地分割热带装饰用的梨树栽培变种 IRAT109 适度的装饰用的梨树栽培变种 Yuefu 背景被开发。176 个多态的标记被用来识别 introgressed 片断。从 IRAT109 的片断都没在 160 根线被发现。另外的 270 根线的 Introgressed 片断盖住 99.1% 施主染色体。introgressed 施主片断的吝啬的数字与 14.4 厘米的平均长度每个人是 3.3。QTL 分析在在灌溉低地,高地和水耕法的条件下面种的 270 IL 的基础根厚度(BRT ) 上被进行。影响 BRT 的 22 QTL 的一个总数被识别,六 QTL (qBRT3.1, qBRT3.2, qBRT6.1, qBRT8.2, qBRT9.1,和 qBRT9.2 ) 一致地在至少二环境(地点和水政体) 下面被表示,并且 qBRT7.2 是在低地条件下面识别的新 BRT QTL。包含 qBRT9.1 的 IL255 在栽培变种 Yuefu 上看了 10.09% 和 7.07% BRT 的增加什么时候分别地在高地和低地条件下面成长。用 304 根 F2:3 线的一张人口源于生气 IL255 ??????? 瑡歭?? 匠 ? 彋 ????????? 僚 ?? 传敶敲灸敲獳潩吗?? | Junzhou Li Deping Wang Yan Xie Hongliang Zhang Guanglong Hu Jinjie Li Anyong Dai Lifeng Liu Zichao Li | 2011 | Journal of Genetics and Genomics2011，38，11： | 3 |
| 3 | Expression profiles of genes involved in jasmonic acid biosynthesis and signaling during growth and development of carrot显示文摘Jasmonates (JA ) 响应环境刺激和植物开发作为必要管理者被认出。胡萝卜是有大价值的一棵 Apiaceae 蔬菜并且在植物生长的功课上经历重要尺寸变化。然而,在胡萝卜生长的 JA 累积和它的潜在的角色仍然保持不清楚。这里,甲基 JA (MeJA ) 层次和 JA 相关的基因的表示侧面在五个发展阶段在胡萝卜根和叶子被分析。在根和叶子的 MeJA 层次在第一个阶段是最高的并且当胡萝卜生长继续了,减少了。几 JA 相关的基因(Dc13-LOX1 Dc13-LOX2, DcAOS, DcAOC, DcOPR2, DcOPR3, DcOPCL1, DcJAR1, DcJMT, DcCOI1, DcJAZ1, DcJAZ2, DcMYC2, DcCHIB/PR3, DcLEC,和 DcVSP2 ) 的抄本层次很好没在胡萝卜根和叶开发期间与 MeJA 累积被相关另外,一些 JA 相关的基因(DcJAR1, DcJMT, DcCOI1, DcMYC2,和 DcVSP2 ) 显示出在根和叶子之间的微分表示。这些结果建议 JA 可以在阶段依赖者和器官特定的礼貌调整胡萝卜植物生长。我们的工作在胡萝卜生长和开发期间提供新奇卓见进 JA 累积和它的潜在的角色。 | Guanglong Wang Wei Huang Mengyao Li Zhisheng Xu Feng Wang Aisheng Xiong | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 2 |
| 4 | The relati onship between smoke concentration some distance down the hallway and the opening of the room of fire origin显示文摘 | Fang Tingyong Yang Li zhong Huang Rui Feng Wenxing Zhai Guanglong Fan Weicheng | 2003 | Journal of Fire Sciences2003，21，4： | 1 |
| 5 | Investigation on flame retardancy and thermal degradation of flame retardant poly(butylene suceinate)/bam- boo fiber biocomposites显示文摘 | Nie Shibin Liu Xueli Dai Guanglong Yuan Shujie Cai Feng Li Benxia Hu Yuan | 2012 | Journal of Applied Polymer Sci enee2012，125，： | 1 |
| 6 | Layered sphere-shaped TiO_2 capped with gold nanoparticles on structural defects and their catalysis of formaldehyde oxidation显示文摘We describe here a one-step method for the synthesis of Au/TiO_2 nanosphere materials,which were formed by layered deposition of multiple anatase TiO_2 nanosheets.The Au nanoparticles were stabilized by structural defects in each TiO_2 nanosheet,including crystal steps and edges,thereby fixing the Au-TiO_2 perimeter interface.Reactant transfer occurred along the gaps between these TiO_2 nanosheet layers and in contact with catalytically active sites at the Au-TiO_2 interface.The doped Au induced the formation of oxygen vacancies in the Au-TiO_2 interface.Such vacancies are essential for generating active oxygen species(~*O^-) on the TiO_2 surface and Ti^(3+) ions in bulk TiO_2.These ions can then form Ti^(3+)-O^--Ti^(4+)species,which are known to enhance the catalytic activity of formaldehyde(HCHO) oxidation.These studies on structural and oxygen vacancy defects in Au/TiO_2 samples provide a theoretical foundation for the catalytic mechanism of HCHO oxidation on oxide-supported Au materials. | Chunyan Ma Guanglong Pang Guangzhi He Yang Li Chi He Zhengping Hao | 2016 | Journal of Environmental Sciences2016，28，1： | 1 |
| 7 | Representation of conspecific vocalizations in amygdala of awake marmosets显示文摘Human speech and animal vocalizations are important for social communication and animal survival.Neurons in the auditory pathway are responsive to a range of sounds,from elementary sound features to complex acoustic sounds.For social communication,responses to distinct patterns of vocalization are usually highly specific to an individual conspecific call,in some species.This includes the specificity of sound patterns and embedded biological information.We conducted single-unit recordings in the amygdala of awake marmosets and presented calls used in marmoset communication,calls of other species and calls from specific marmoset individuals.We found that some neurons(47/262)in the amygdala distinguished‘Phee’calls from vocalizations of other animals and other types of marmoset vocalizations.Interestingly,a subset of Phee-responsive neurons(22/47)also exhibited selectivity to one out of the three Phees from two different‘caller’marmosets.Our findings suggest that,while it has traditionally been considered the key structure in the limbic system,the amygdala also represents a critical stage of socially relevant auditory perceptual processing. | Guoqiang Jia Siyi Bai Yingxu Lin Xiaohui Wang Lin Zhu Chenfei Lyu Guanglong Sun Kang An Anna Wang Roe Xinjian Li Lixia Gao | 2023 | National Science Review2023，10，11： | 1 |
| 8 | Transgenic over expression of ectonucleotide triphosphate diphosphohydrolase-1 protects against murine myocardial ischemic injury显示文摘 | Ming Cai Zachary M. Huttinger Heng He Weizhi Zhang Feng Li Lauren A. Goodman Debra G. Wheeler Lawrence J. Druhan Jay L. Zweier Karen M. Dwyer Guanglong He Anthony J.F. d’Apice Simon C. Robson Peter J. Cowan Richard J. Gumina | 2011 | Journal of Molecular and Cellular Cardiology2011，，6： | 1 |
| 9 | Computational diffusion kinetics and its applications in study and design of rare metallic materials显示文摘Computational diffusion kinetics(CDK),with a spirit of and being coupled with the computational thermodynamics(CT,or called as the CALPHAD technique),plays increasingly important role in the alloy design/optimization and microstructure control during the processing of advanced metallic materials.This paper is to highlight recent progress of CDK in research with great focus on novel Ti and Zr alloys,which was largely performed in the authors’group.It ends with one representative example of the applications of CDK,coupled with CT,quantitative phase field,and three-dimensional(3D)statistical calculation,in designing the heattreatment schedule for the dual phase(αβ)Ti–6Al–4V alloys. | Yuwen Cui Guanglong Xu Yi Chen Bin Tang Jinshan Li Lian Zhou | 2014 | Chinese Science Bulletin2014，59，15： | 1 |
| 10 | Notch1 Expression in Colorectal Carcinoma Determines Tumor Differentiation Status显示文摘 | Dake Chu Weizhong Wang Huahong Xie Yunming Li Guanglong Dong Chunsheng Xu Dongli Chen Jianyong Zheng Mengbin Li Zifan Lu Gang Ji | 2009 | Journal of Gastrointestinal Surgery2009，，2： | 1 |
| 11 | Late phase ischemic preconditioning preserves mitochondrial oxygen metabolism and attenuates post-ischemic myocardial tissue hyperoxygenation显示文摘 | Yuanjing Li Ming Cai Yi Xu Harold M. Swartz Guanglong He | 2010 | Life Sciences2010，，1： | 1 |
| 12 | High Level of Notch1 Protein is Associated with Poor Overall Survival in Colorectal Cancer显示文摘 | Dake Chu MD Yunming Li MD Weizhong Wang MM Qingchuan Zhao MD Jipeng Li MD Yuanyuan Lu MD Mengbin Li MD Guanglong Dong MD Hongwei Zhang MD Huahong Xie MD Gang Ji MD | 2010 | Annals of Surgical Oncology2010，，5： | 1 |
| 13 | Downregulation of tumor suppressor QKI in gastric cancer and its implication in cancer prognosis显示文摘 | Yongqian Bian Li Wang Huanyu Lu Guodong Yang Zhang Zhang Haiyan Fu Xiaozhao Lu Mengying Wei Jianyong Sun Qingchuan Zhao Guanglong Dong Zifan Lu | 2012 | Biochemical and Biophysical Research Communications2012，，1： | 1 |
| 14 | Water bridges are essential to neonicotinoids: Insights from synthesis,bioassay and molecular modelling studies显示文摘Water-bridged H-bonds have been observed in many cases of ligand-receptor recognitions. To explore the roles of water bridges in the binding of neonicotinoids with receptors, twenty-four neonicotinoid compounds with nine fragments, including 1 H-1,2,3-triazole, CN, COOMe, CONHNH_2, CONHMe, NO_2,NH_2, NHCOMe and NHCSNH_2 were synthesized and evaluated, of which, compounds with cyano group showed the best activities against Aphis craccivora. Accordingly, the cyano group is the optimal fragment mimicking the water bridge. Two cyano-substituted cis-nitromethylene compounds display good insecticidal activities, whereas the LC_(50) values are lower than those of their corresponding prototypes.Docking study showed that the cyano group acts only as H-bond acceptor, while the water bridge can act as both donor and acceptor. It revealed that the water bridge might be stable in the active site and was not suitable to be replaced by other groups. The findings illustrated that the water bridge is necessary for high insecticidal activities of neonicotinoids, which should be also helpful in better understanding the binding mode of neonicotinoids. | Chengchun Zhu Guanglong Li Keya Xiao Xusheng Shao Jiagao Cheng Zhong Li | 2019 | Chinese Chemical Letters2019，30，1： | 0 |
| 15 | Cloning and Drought Resistance Analysis of Soybean GmHsps_p23-like Gene显示文摘Soybean(Glycine max(L.)Merr.)is an important cultivated crop,which requires much water during its growth,and drought seriously affects soybean yields.Studies have shown that the expression of small heat shock proteins can enhance drought resistance,cold resistance and salt resistance of plants.In this experiment,soybean GmHsps_p23-like gene was successfully cloned by RT-PCR,the protein encoded by the GmHsps_p23-like gene was subjected to bioinformatics analysis,and the pCAMBIA3301-GmHsps_p23-like overexpression vector and pCBSG015-GmHsps_p23-like gene editing vector were constructed.Agrobacterium-mediated method was used to transform soybeans to obtain positive plants.RT-PCR detection,rehydration experiment and drought resistance physiological and biochemical index detection were performed on the T2 generation positive transgenic soybean plants identified by PCR and Southern hybridization.The results showed that the overexpression vector plant GmHsps_p23-like gene expression increased.After rehydration,the transgenic overexpression plants returned to normal growth,and the damage to the plants was low.After drought stress,the SOD and POD activities and the PRO content of the transgenic overexpression plants increased,while the MDA content decreased.The reverse was true for soybean plants with genetically modified editing vectors.The drought resistance of the overexpressed soybeans under drought stress was higher than that of the control group,and had a stronger drought resistance.It showed that the expression of soybean GmHsps_p23-like gene can improve the drought resistance of soybean.The cloning and functional verification of soybean GmHsps_p23-like gene had not been reported yet.This is the first time that PCR technology has been used to amplify the soybean GmHsps_p23-like gene and construct an expression vector for this gene.This research has laid the foundation for transgenic technology to improve plant drought resistance and cultivate new drought-resistant transgenic soybean varieties. | Yuzhe Zhang Guanglong Li Shaowang Hu Jinfeng Liu Yushi Jiang Siyan Liu Shuyan Guan Jing Qu Dan Yao Andi Shi Yixuan Liu | 2022 | Phyton-International Journal of Experimental Botany2022，91，6： | 0 |
| 16 | Saturation efficiency for detecting 1550 nm photons with a 2×2 array of Mo0.8Si0.2 nanowires at 2.2 K显示文摘Amorphous materials are attractive candidates for fabricating the superconducting nanowire single-photon detectors(SNSPDs) due to their superior tolerance and scalability over crystalline niobium nitride. However, the reduced superconducting transition temperature degenerates both operating temperature and saturation efficiency. Herein, the SNSPD(6.5 nm thickness and 50 nm width) based on the amorphous Mo0.8Si0.2 film with a high optical absorption coefficient demonstrates close-to-unity intrinsic detection efficiency for 1550 nm photons from 75 m K to 2.2 K. Further, a high-performance array SNSPD with optimized 90 nm-width wires is also demonstrated. As-fabricated uniform 4-pixel SNSPD exhibits a saturation plateau for the photon counts at 2.2 K,which overcomes the limitation of operation at low temperature(< 1 K) for traditional amorphous SNSPDs.Coupled with superior intrinsic quantum efficiency, highly efficient photon counts, and low dark count ratio, this detector paves a way for achieving high efficiency and superior yield for large array systems. | Feiyan Li Hang Han Qi Chen Biao Zhang Han Bao Yue Dai Rui Ge Shuya Guo Guanglong He Yue Fei Shuchao Yang Xiaohan Wang Hao Wang Xiaoqing Jia Qingyuan Zhao Labao Zhang Lin Kang Peiheng Wu | 2021 | Photonics Research2021，9，3： | 0 |
| 17 | Inhibitory Effects of 12 Chemical Agents against Alternaria alternata显示文摘[Objective]The paper was to screen highly efficient fungicides for the prevention and control of tobacco brown spot(Alternaria alternata).[Method]The inhibitory effects of 12 chemical agents against A.alternata were determined indoors by mycelium growth rate method.[Result]Toxicity test showed that 30%kresoxim-methyl·boscalid SC had the best inhibitory effect,with an EC_(50)of 1.05μg/mL,followed by 9%pyraclostrobin CS,with an EC_(50)of 2.09μg/mL.As a broad spectrum protective fungicide,77%copper calcium sulfate WP showed a low sensitivity against A.alternata in the petri dish test since it had a mechanism of action different from that of other chemical agents.[Conclusion]The study lays the foundation for subsequent screening of fungicides for the prevention and control of A.alternata in the field. | Shen Hong Zhang Jiatao Cui Zhiyan Sun Guangjun Li Bin Zhang Yongfeng Xu Chuantao Ai Yongfeng Song Guanglong Ji Xiuting Wang Xiaoqiang | 2020 | Plant Diseases and Pests2020，11，4： | 0 |
| 18 | Comparison of Computed Tomography Imaging with Traditional Autopsy Results显示文摘The role of computed tomography(CT)images in forensic identification has been widely recognized.Such images can provide an important basis for identification of the cause of death in complicated and difficult cases,including falls from a height,drowning,explosion and gunshot cases,traffic accidents,and sudden death.However,few reports have focused on the application of CT images in cases of death caused by sharp object injuries.Therefore,the CT images and autopsy findings were compared in a case of death caused by sharp object injuries to the chest and abdomen,and the importance of CT images in cases of death from common sharp object injuries is herein discussed. | Yang Li Yang Li Bin Wu Bin Wu Yongbo Wu Hongliang Zhu Jian Wang Jianjun Li Guanglong He | 2021 | Journal of Forensic Science and Medicine2021，7，1： | 0 |
| 19 | Single-cell analyses identify anaphase-promoting complex subunit 11 as a switch controlling neuronal differentiation of glioblastoma cells显示文摘Glioblastoma(GBM)is the most common and lethal malignancy in the central nervous system.1 One of the major difficulties in treatment is that the initial clinical diagnosis of GBM is already WHO grade IV,without recognizable lower-grade precursor lesions.Copy number variations(CNVs)were found to appear in malignant cells several years before the initial diagnosis of GBM.2 Less differentiation and more aggressive phenotypes were observed in GBM cells with a higher degree of CNVs.3 Additionally,CNVs provide more accurate stratification of clinical outcomes than does the WHO grade system.4 Therefore,we reasoned that differentially expressed genes(DEGs)among GBM cells with different CNV statuses would be significant for the aggressiveness of GBM.Here we leveraged the single-cell RNA-sequencing(scRNA-seq)to construct the CNV profile of GBM at single-cell resolution,divided GBM cells into different clusters according to their CNV statuses,and investigated the molecular functions of DEGs among GBM clusters.Through a series of experiments,we identified anaphase-promoting complex subunit 11(ANAPC11)as a switch controlling the neuronal differentiation of GBM cells,providing a novel alternative for the development of differentiation-inducing therapy to overcome GBM. | Runwei Yang Ziyu Wang Songtao Qi Bowen Ni Jinglin Guo Kaishu Li Haimin Song Sidi Xie Yunxiao Zhang Xirang Wang Chunmao He Guanglong Huang Yawei Liu | 2023 | Genes & Diseases2023，10，5： | 0 |
| 20 | Targeting the ferroptosis crosstalk:novel alternative strategies for the treatment of major depressive disorder显示文摘Depression is a major contributor to poor global health and disability,with a recently increasing incidence.Although drug therapy is commonly used to treat depression,conventional antidepressant drugs have several disadvantages,including slow onset,low response rates and severe adverse effects.Therefore,developing effective therapies for depression remains challenging.Although various aetiological theories of depression exist,the underlying mechanisms of depression are complex,and further research is crucial.Moreover,oxidative stress(OS)-induced lipid peroxidation has been demonstrated to trigger ferroptosis.Both OS and ferroptosis are pivotal mechanisms implicated in the pathogenesis of neurological disorders,and investigation of the mediators involved in these processes has emerged as a prominent and active research direction.One previous study revealed that regulatory proteins involved in ferroptosis are implicated in the pathogenesis of depression,and antidepressant drugs could reverse depressive symptoms by inhibiting ferroptosis in vivo,suggesting an important role of ferroptosis in the pathogenesis of depression.Hence,our current comprehensive review offers an up-to-date perspective on the intricate mechanisms involved,specifically concerning ferroptosis and OS in the context of depression,along with promising prospects for using molecular mediators to target ferroptosis.We delineate the key targets of molecular mediators involved in OS and ferroptosis implicated in depression,most notably reactive oxygen species and iron overload.Considering the pivotal role of OS-induced ferroptosis in the pathogenesis of neurological disorders,delving deeper into the underlying subsequent mechanisms will contribute significantly to the identification of novel therapeutic targets for depression. | Luyao Wang Rongyang Xu Chengying Huang Guozhong Yi Zhiyong Li Huayang Zhang Rongxu Ye Songtao Qi Guanglong Huang Shanqiang Qu | 2023 | General Psychiatry2023，36，5： | 0 |
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