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| 1 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 2 | Downstaging and resection of hepatocellular carcinoma in patients with extrahepatic metastases after stereotactic therapy显示文摘Background:A combination of tyrosine kinase inhibitors(TKIs)and anti-PD-1 antibodies with local regional therapy has elicited yield substantial clinical benefits in patients who have hepatocellular carcinoma(HCC)with extrahepatic metastases.Using this treatment strategy to convert HCC patients with extrahepatic metastases from unresectable to resectable has not yet been reported.Methods:Consecutive hepatocellular carcinoma patients with extrahepatic metastases who received first-line therapy with a combination of TKIs and anti-PD-1 antibodies and at least one local regional therapy were analysed.Results:Nine patients with localized disease who received first-line systemic therapy were enrolled.At baseline,all of them had oligometastatic disease,namely,Barcelona Clinic Liver Cancer stage C(or Chinese Liver Cancer stage IIIB).The most common treatment administered was lenvatinib plus anti-PD-1 antibody and transarterial chemoembolization,and the median time span from systemic therapy to surgery was 3.2(IQR,2.8-6.2)months.Three patients achieved a pathological complete response.Six patients underwent laparoscopic surgery,and the other 3 patients underwent open surgery.After a median follow-up of 10.2(IQR,8.6-20.0)months,7 patients survived without disease recurrence,and 2 experienced tumour recurrence.All patients had any-grade AEs,and 55.6%of the patients experienced grade 3 AEs.Fatigue was the most common AE,followed by elevated aminotransferase levels and hypertension.Conclusions:Stereotactic therapy is a feasible conversion therapy for HCC patients with extrahepatic metastases to become resectable.This is the first study to analyse therapeutic outcomes of patients receiving these therapies for HCC with extrahepatic metastases. | Xiaobo Yang Haifeng Xu Bangyou Zuo Xu Yang Jin Bian Junyu Long Dongxu Wang Junwei Zhang Cong Ning Yanyu Wang Ziyu Xun Yunchao Wang Xin Lu Yilei Mao Xinting Sang Haitao Zhao | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 17 |
| 3 | Discriminative graph regularized broad learning system for image recognition显示文摘Broad learning system(BLS) has been proposed as an alternative method of deep learning. The architecture of BLS is that the input is randomly mapped into series of feature spaces which form the feature nodes, and the output of the feature nodes are expanded broadly to form the enhancement nodes, and then the output weights of the network can be determined analytically. The most advantage of BLS is that it can be learned incrementally without a retraining process when there comes new input data or neural nodes. It has been proven that BLS can overcome the inadequacies caused by training a large number of parameters in gradient-based deep learning algorithms. In this paper, a novel variant graph regularized broad learning system(GBLS) is proposed. Taking account of the locally invariant property of data, which means the similar images may share similar properties, the manifold learning is incorporated into the objective function of the standard BLS. In GBLS, the output weights are constrained to learn more discriminative information,and the classification ability can be further enhanced. Several experiments are carried out to verify that our proposed GBLS model can outperform the standard BLS. What is more, the GBLS also performs better compared with other state-of-the-art image recognition methods in several image databases. | Junwei JIN Zhulin LIU C.L.Philip CHEN | 2018 | Science China(Information Sciences)2018，61，11： | 12 |
| 4 | Efficient spectral regulation in Ce:Lu_(3)(Al,Cr)_(5)O_(12) and Ce:Lu_(3)(Al,Cr)_(5)O_(12)/Ce:Y_(3)Al_(5)O_(12) transparent ceramics with high color rendering index for high-power white LEDs/LDs显示文摘Realizing a high color rendering index(CRI)in Ce:LuAG transparent ceramics(TCs)with desired thermal stability is essential to their applications in white LEDs/LDs as color converters.In this study,based on the scheme of configuring the red component by Cr^(3+) doping,an efficient spectral regulation was realized in Ce,Cr:LuAG TCs.A unilateral shift phenomenon could be observed in both photoluminescence(PL)and photoluminescence excitation(PLE)spectra of TCs.By constructing TC-based white LED/LD devices in a remote excitation mode,luminescence properties of Ce,Cr:LuAG TCs were systematically investigated.The CRI values of Ce:LuAG TC based white LEDs could be increased by a magnitude of 46.2%.Particularly,by combining the as fabricated Ce,Cr:LuAG TCs with a 0.5 at% Ce:YAG TC,surprising CRI values of 88 and 85.5 were obtained in TC based white LEDs and LDs,respectively.Therefore,Ce,Cr:LuAG TC is a highly promising color convertor for high-power white LEDs/LDs applied in general lighting and displaying. | Tianyuan ZHOU Chen HOU Le ZHANG Yuelong MA Jian KANG Tao LI Rui WANG Jin HUANG Junwei LI Haidong REN Zhenxiao FU Farida ASELIM Ming LI Hao CHEN | 2021 | Journal of Advanced Ceramics2021，10，5： | 7 |
| 5 | The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR显示文摘On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates,which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline.Of particular note,2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale.It provides all identified variants and their detailed statistics for each virus isolate,and congregates the quality score,functional annotation,and population frequency for each variant.Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available.Moreover,2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019(COVID-19),including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC.Furthermore,by linking with relevant databases in CNCB,2019nCoVR offers data submission services for raw sequence reads and assembled genomes,and data sharing with NCBI.Collectively,SARS-CoV-2 is updated daily to collect the latest information on genome sequences,variants,haplotypes,and literature for a timely reflection,making 2019nCoVR a valuable resource for the global research community.2019nCoVR is accessible at https://bigd.big.ac.cn/ncov/. | Shuhui Song Lina Ma Dong Zou Dongmei Tian Cuiping Li Junwei Zhu Meili Chen Anke Wang Yingke Ma Mengwei Li Xufei Teng Ying Cui Guangya Duan Mochen Zhang Tong Jin Chengmin Shi Zhenglin Du Yadong Zhang Chuandong Liu Rujiao Li Jingyao Zeng Lili Hao Shuai Jiang Hua Chen Dali Han Jingfa Xiao Zhang Zhang Wenming Zhao Yongbiao Xue Yiming Bao | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 4 |
| 6 | PEPT1-mediated prodrug strategy for oral delivery of peramivir显示文摘Peramivir was a novel and highly potent neuraminidase(NA) inhibitor for the treatment of influenza A and B. However, it exhibited a very low oral bioavailability(only 3%) due to the high polarity(log P of-1.4) and the low membrane permeability across the intestine. To utilize the PEPT1-mediated prodrug strategy to improve the oral absorption and develop the oral alternative, seven amino acid ester prodrugs and seven amino acid amide prodrugs have been synthesized. The permeability of these prodrugs across Caco-2 cells were screened. Peramivr-(CH_2)_2-l-Val and Peramivir-l-Ile were of the highest permeability in ester prodrugs and amide prodrugs, respectively, and then they were selected for further studies. Glycylsarcosine(gly-sar) uptake by Caco-2 could be inbihited by Peramivir-(CH_2)_2-l-Val and Peramivir-l-Ile in a concentration-dependent manner, and the IC 50 was 1.34 ± 0.31 m M and 1.78 ± 0.48 m M, respectively. The direct uptake of Peramivir-(CH_2)_2-l-Val and Peramivirl-Ile in MDCK-PEPT1 cells were significantly higher than in MDCK mock cells, and could be markedly inhibited by gly-sar. The uptake of Peramivir-(CH_2)_2-l-Val and Peramivir-l-Ile(0.01 to 50 m M) in MDCK-hPEPT1 cells conformed to Michaelis–Menten Equation. The oral bioavailability of peramivir was 65.3% and 37.3% after the oral administration of Peramivir-(CH_2)_2-l-Val and Peramivir-l-Ile to rats, respectively. The oral absorption and bioactivation of Peramivir-(CH_2)_2-l-Val was rapid and extensive, and no Peramivir-(CH_2)_2-l-Val was found in plasma. Because the amide bond was relatively stable, Peramivir-l-Ile could not be totally converted to the parent drug in vivo. Peramivir-(CH_2)_2-l-Val with good oral profiles and rapid bioactivation might be a promising prodrug for the further clinic development. The present study also corroborated the idea that the PEPT1-mediated prodrug approach has enormous promise for improving the oral absorption of poorly absorbed drug. | Yongbing Sun Wei Gan Mingdao Lei Wei Jiang Meng Cheng Junwei He Qi Sun Wan Liu Lvjiang Hu Yi Jin | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，6： | 4 |
| 7 | Influence of nano-diamond content on the microstructure,mechanical and thermal properties of the ZK60 composites显示文摘The effect of nano diamond(ND)content on the microstructure,mechanical properties,and thermal conductivity of ZK60+x(x=0,0.05,0.1,0.15,0.2 wt.%)ND composites were investigated.The microstructures of ND/ZK60 composites were observed,which indicated that the nanoscale MgZn_(2) and ND particles distributed evenly in theα-Mg matrix.The tensile yield strength(TYS)and compressive yield strength(CYS)of the composites first increased remarkably and then decreased with further increasing the ND content.Due to the surface area of the matrix-diamond interface increased and the grains sizes of composites decreased with the amount of ND increase,which cause the coefficient of thermal expansion(CTE)of the composites reduced significantly.Meanwhile,the thermal conductivity of the composite material decreases from 129 W·m^(−1)·K^(−1) to 116 W·m^(−1)·K^(−1) with the content of ND increasing from 0.05%to 2.0%.The thermal conductivity of the composites increases to the maximum and then decrease with the increase of temperature(in temperature range of 273-573 K).The ZK60+0.05 ND showed superior mechanical and thermal conductivity property,TYS of 343.97 MPa,CYS of 341.74 MPa,elongation of 15.71%,CTE of 7.3×10^(−6)K^(−1),and thermal conductivity of 129 W·m^(−1)·K^(−1) at room temperature.It is demonstrated that the ND content has an obvious influence on the microstructure,mechanical properties,and thermal conductivity of ND/ZK60 composites. | Hongbin Ma Jinhui Wang Hongyu Wang Ningning Dong Junwei Zhang Peipeng Jin Yong Peng | 2022 | Journal of Magnesium and Alloys2022，10，2： | 3 |
| 8 | miR-34 is associated with poor prognosis of patients with gallbladder cancer through regulating telomere length in tumor stem cells显示文摘 | Ke Jin Yonghua Xiang Jing Tang Guangchun Wu Junwei Li Huaichun Xiao Chunwang Li Yuxiang Chen Jingfeng Zhao | 2014 | Tumor Biology2014，，2： | 1 |
| 9 | Targeting IL-22 and IL-22R protects against experimental osteoarthritis显示文摘Osteoarthritis(OA)is characterized by cartilage degradation,pain,and synovitis.1 Joint inflammation driven by cytokines has been demonstrated to cause cartilage degradation and pain.2 However,approaches to neutralize cytokines,such as IL-1 and TNF-α,known to be involved in OA have shown poor clinical efficacy.3 There is an unmet clinical need to find better anti-inflammatory and pain targets for OA therapy and to elucidate the role of other cytokines in OA pathogenesis.Previous studies have shown that IL-22 and its receptor IL-22R play central roles in inflammation and diseases such as psoriasis,ulcerative colitis,graft-versus-host disease,certain infections and tumors,as well as in liver and pancreas damage.4,5 The role of IL-22/IL-22R and the potential for therapeutic targeting of both proteins in OA remain largely unknown,which we sought to investigate. | Changhua Yi Yongxiang Yi Jie Wei Qingwen Jin Junwei Li Pradeep Kumar Sacitharan | 2021 | Cellular & Molecular Immunology2021，18，5： | 1 |
| 10 | An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease显示文摘Background:With the rising global prevalence of fatty liver disease related to metabolic dysfunction,the association of this common liver condition with chronic kidney disease(CKD)has become increasingly evident.In 2020,the more inclusive term metabolic dysfunction-associated fatty liver disease(MAFLD)was proposed to replace the term non-alcoholic fatty liver disease(NAFLD).The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without MAFLD.However,to date,there is no appropriate guidance on CKD in individuals with MAFLD.Furthermore,there has been little attention paid to the link between MAFLD and CKD in the Nephrology community.Methods and Results:Using a Delphi-based approach,a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on some of the open research questions regarding the link between MAFLD and CKD.Conclusions:This Delphi-based consensus statement provided guidance on the epidemiology,mechanisms,management and treatment of MAFLD and CKD,as well as the relationship between the severity of MAFLD and risk of CKD,which establish a framework for the early prevention and management of these two common and interconnected diseases. | Dan-Qin Sun Giovanni Targher Christopher D.Byrne David C.Wheeler Vincent Wai-Sun Wong Jian-Gao Fan Herbert Tilg Wei-Jie Yuan Christoph Wanner Xin Gao Michelle T.Long Mehmet Kanbay Mindie H.Nguyen Sankar D.Navaneethan Yusuf Yilmaz Yuli Huang Rino A.Gani Pierluigi Marzuillo Jérôme Boursier Huijie Zhang Chan-Young Jung Jin Chai Luca Valenti George Papatheodoridis Giovanni Musso Yu-Jun Wong Mohamed El-Kassas Nahum Méndez-Sánchez Silvia Sookoian Michael Pavlides Ajay Duseja Adriaan G.Holleboom Junping Shi Wah-Kheong Chan Yasser Fouad Junwei Yang Sombat Treeprasertsuk Helena Cortez-Pinto Masahide Hamaguchi Manuel Romero-Gomez Mamun Al Mahtab Ponsiano Ocama Atsushi Nakajima Chunsun Dai Mohammed Eslam Lai Wei Jacob George Ming-Hua Zheng | 2023 | Hepatobiliary Surgery and Nutrition2023，12，3： | 1 |
| 11 | Adiponectin exacerbates influenza infection in elderly individuals via IL-18显示文摘Dear Editor,Influenza affects humans of all ages;however,elderly people have increased susceptibility to infections and are especially predisposed to complications.1 A number of global efforts have increased influenza vaccination administration in elderly people to reduce complications,particularly when seasonal influenza infections peak.2 To date,much is known about how influenza infection and host immunity interact during pathogenesis,which has led to a number of vaccines.3,4 However,the impact of influenza vaccines in older people is modest.2 Hence,the underlying pathophysiological mechanisms responsible for the worsening of influenza infection in old age are still elusive. | Youzhu Jiang Changhua Yi Yongxiang Yi Qingwen Jin Angray SKang Junwei Li Pradeep Kumar Sacitharan | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 12 | Tamoxifen reduces P-gp-mediated multidrug resist- ance via inhibiting the PI3 K/Akt signaling pathway in ER-negative human gastric cancer cells 显示文摘 | ZONGLEI MAO JIN ZHOU JUNWEI LUAN | 2014 | Biomed Pharmacother2014，68，： | 1 |
| 13 | A new global gridded sea surface temperature product constructed from infrared and microwave radiometer data using the optimum interpolation method显示文摘A new 0.1° gridded daily sea surface temperature(SST) data product is presented covering the years 2003–2015. It is created by fusing satellite SST data retrievals from four microwave(Wind Sat, AMSR-E, ASMR2 and HY-2 A RM)and two infrared(MODIS and AVHRR) radiometers(RMs) based on the optimum interpolation(OI) method. The effect of including HY-2 A RM SST data in the fusion product is studied, and the accuracy of the new SST product is determined by various comparisons with moored and drifting buoy measurements. An evaluation using global tropical moored buoy measurements shows that the root mean square error(RMSE) of the new gridded SST product is generally less than 0.5℃. A comparison with US National Data Buoy Center meteorological and oceanographic moored buoy observations shows that the RMSE of the new product is generally less than 0.8℃. A comparison with measurements from drifting buoys shows an RMSE of 0.52–0.69℃. Furthermore, the consistency of the new gridded SST dataset and the Remote Sensing Systems microwave-infrared SST dataset is evaluated, and the result shows that no significant inconsistency exists between these two products. | SUN Weifu WANG Jin ZHANG Jie MA Yi MENG Junmin YANG Lei MIAO Junwei | 2018 | Acta Oceanologica Sinica2018，37，9： | 1 |
| 14 | Applying deep neural networks to the detection and space parameter estimation of compact binary coalescence with a network of gravitational wave detectors显示文摘In this paper, we study an application of deep learning to the advanced laser interferometer gravitational wave observatory(LIGO)and advanced Virgo coincident detection of gravitational waves(GWs) from compact binary star mergers. This deep learning method is an extension of the Deep Filtering method used by George and Huerta(2017) for multi-inputs of network detectors.Simulated coincident time series data sets in advanced LIGO and advanced Virgo detectors are analyzed for estimating source luminosity distance and sky location. As a classifier, our deep neural network(DNN) can effectively recognize the presence of GW signals when the optimal signal-to-noise ratio(SNR) of network detectors ≥ 9. As a predictor, it can also effectively estimate the corresponding source space parameters, including the luminosity distance D, right ascension α, and declination δ of the compact binary star mergers. When the SNR of the network detectors is greater than 8, their relative errors are all less than 23%.Our results demonstrate that Deep Filtering can process coincident GW time series inputs and perform effective classification and multiple space parameter estimation. Furthermore, we compare the results obtained from one, two, and three network detectors;these results reveal that a larger number of network detectors results in a better source location. | XiLong Fan Jin Li Xin Li YuanHong Zhong JunWei Cao | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，6： | 1 |
| 15 | FOXM1 expression predicts the prognosis in hepatocellular carcinoma patients after orthotopic liver transplantation combined with the Milan criteria显示文摘 | Hongcheng Sun Mujian Teng Jie Liu Dong Jin Junyi Wu Dongwang Yan Junwei Fan Xuebin Qin Huamei Tang Zhihai Peng | 2011 | Cancer Letters2011，，2： | 1 |
| 16 | 6-15 Status Report of On-line Ion Sources in 2015显示文摘In 2015, the service time of the two on-line ion sources of HIRFL-CSR accelerator facility, SECRAL and LECR3, is 3 335.5 and 3 168.5 h, respectively, amouting to 6 504 h. Except 26Mg7+, which was required by the accelerator but failed to be produced due the oxidation of the material, 20 kinds of ion beams have been delivered successfull.The failure time is 49 h this year, mainly attributed to the breakdown of the cryostat system. | Feng Yucheng Lu Wang Zhang Wenhui Ma Hongyi Yang Yao Fang Xing Guo Junwei Ma Baohua Wang Hui Qian Cheng Zhang Junjie Li Jibo Jin Qianyu sheng Sifan Liu Pengyan Li Xixia Zhao Huanyu Zhang Xuezhen Sun Liangting | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 17 | N-Heterocycles Extended π-Conjugation Enables Ultrahigh Capacity,Long-Lived,and Fast-Charging Organic Cathodes for Aqueous Zinc Batteries显示文摘The aqueous zinc-organic battery is a promising candidate for large-scale energy storage.However,the rational design of advanced organic cathodes with high capacity,long lifespan,and high rate capability remains a big challenge.Herein,we propose that extending theπ-conjugation by N-heterocycles can provide more active sites,lead to insolubility,and facilitate charge transfer,thus boosting the overall electrochemical performance of organic electrodes.Based on this concept,a novel organic compound,dipyrido[3ʹ,2ʹ:5,6;2″,3″:7,8]quinoxalino[2,3-i]dipyrido[3,2-a:2ʹ,3ʹ-c]phenazine-10,21-dione(DQDPD),has been rationally designed and evaluated as the cathode for aqueous zinc batteries.Excitingly,DQDPD shows a record high capacity(509 mAh g^(−1) at 0.1 A g^(−1),corresponding to a record-breaking energy density of 348 Wh kg^(−1)),excellent cycling stability(92%capacity retention after 7500 cycles at 10 A g^(−1)),and fast-charging capability(161 mAh g^(−1) at 20 A g^(−1)).Our work offers new ideas in the molecular engineering of organic electrodes for high-performance rechargeable batteries. | Huiling Peng Jin Xiao Zhonghan Wu Lei Zhang Yaheng Geng Wenli Xin Junwei Li Zichao Yan Kai Zhang Zhiqiang Zhu | 2023 | CCS Chemistry2023，5，8： | 0 |
| 18 | Identification of the Diterpenoids Produced by Endophytic Fungus of Torreya fargesii and Its Inhibitory Effect on Hela Cells显示文摘[Objectives] The purpose of this study is to dissociate endophytic fungus producing diterpenoids from Torreya fargesii tissue and examines its inhibiting effect on tumor cells. [Methods]Plant endophytes were isolated and purified to study their resistance to Gram-positive( G+) and Gram-negative bacteria( G-). High performance liquid chromatography( HPLC) was used for analysis of the retention time,relative peak area and percentage content of its metabolite. By liquid chromatography-mass spectrometry( HPLC-MS),the material characteristic of the ion pair information of the metabolites was measured. The bacterial strain was also classified. [Results] The results showed that the secondary metabolites produced by the strain BP6 T3 possessed double resistance to G+and G-bacteria. The strain was identified as Penicillium sp by preliminary classification. Through HPLC analysis,the retention time of fermentation extracts was 12. 8 min with almost the same as the standard of taxol. According to the chromatograph,the relative peak area was 12 887. 11,the average relative percentage was about 15. 8%,and the content of taxol analogs in fermentation broth reached 16. 59 mg/L. The material characteristic of the formation of ion fragments of taxane analogues in metabolic extracts was identical to that of the taxol standard determined by HPLC-MS. It can be initially determined that strain BP6 T3 can produce taxane compounds. Taxol substance produced by this strain had obvious inhibitory effect on Hela cells with the concentration increasing. Different precursors had a significant effect on the production of paclitaxel metabolites in this strain. L-phenylalanine was used as the precursor and the yield increased most,with an increase rate of 425. 7%. [Conclusions] The strain is expected to be used for mass production in antitumor drug taxol. | Weihua JIN Junwei CAO Yi TU Yi TANG Ran GE Jingwen CHEN Fu XU Qijie XIONG | 2019 | Medicinal Plant2019，10，3： | 0 |
| 19 | Long noncoding RNA PCED1B-AS1 promotes erythroid differentiation coordinating with GATA1 and chromatin remodeling显示文摘Erythropoiesis is a complex and sophisticated multi-stage process regulated by a variety of factors,including the transcription factor GATA1 and non-coding RNA.GATA1 is regarded as an essential transcriptional regulator promoting transcription of erythroidspecific genes—such as long non-coding RNAs(lncRNA).Here,we comprehensively screened lncRNAs that were potentially regulated by GATA1 in erythroid cells.We identified a novel lncRNA—PCED1B-AS1—and verified its role in promoting erythroid differentiation of K562 erythroid cells.We also predicted a model in which PCED1B-AS1 participates in erythroid differentiation via dynamic chromatin remodeling involving GATA1.The relationship between lncRNA and chromatin in the process of erythroid differentiation remains to be revealed,and in our study we have carried out preliminary explorations. | Junwei Zhu Yunxiao Ren Yuanyuan Han Tingting Jin Yanming Li Xiuyan Ruan Hongzhu Qu Shengwen Huang Zhaojun Zhang Xiangdong Fang | 2019 | Blood Science2019，1，2： | 0 |
| 20 | Optimizing the configuration of a clearwell by integrating pilot and full-scale tracer testing显示文摘In this paper,the main factors impacting the plug flow pattern of a clearwell were investigated by integrating pilot-scale,full-scale clearwell tracer testing and computa-tional fluid dynamics(CFD)simulation.It was found that pilot tracer testing,full-scale tracer testing and CFD simulation all demonstrated that the correlation between the ratio of t_(10)/T and L/W can be approximately expressed by:t_(10)/T=0.1894ln(L/W)−0.0494.This study confirmed that the installation of baffles within clearwells is an efficient way to optimize their configuration.In addition,the inlet velocity has a minimal contribution to the ratio of t_(10)/T.However,the ratio of turning channel width to channel width(d/W)significantly contributes to the ratio of t_(10)/T.The optimal ratio of d/W is 0.8-1.2 for maintaining better plug flow pattern.The number of turning channels is one of the main factors that impact the ratio of t_(10)/T.When increasing the number of turning channels,a lower ratio of t_(10)/T is obtained. | LIU Wenjun DU Zhipeng JIN Junwei | 2007 | Frontiers of Environmental Science & Engineering2007，1，3： | 0 |
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