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| 1 | Thrombus aspiration plus intra-infarct-related artery administration of tirofiban improves myocardial perfusion during primary angioplasty for acute myocardial infarction显示文摘我们开发了的背景加 intra-infarct-related 的血栓渴望的新联合策略经由在有圣片断举起的病人的渴望导管的 tirofiban 的动脉(IRA ) 大丸药管理心肌的梗塞(STEMI ) 。这策略能减少远侧的栓塞并且完成 tirofiban 的高度局部性的集中,没有增加流血的风险,它能改进心肌的灌注。这研究的目的在与经历二个组的主要 angioplasty.Results 基线特征的 STEMI 在病人改进心肌的灌注是调查这联合策略是否比血栓渴望优异独自一个的是正常的。TIMI 3 流动独自比在渴望在 intra-IRA 组显示出一个更好的趋势组(97.22% 对 87.04% , X^2=7.863, P=0.049 ) 。CK-MB 的山峰(83.9 (68.9-310.5 ) U/L 对 126.1 (74.7-356.7 ) U/L, P=0.034 ) 并且 Tnl (42.7 (14.7-113.9 ) ng/ml 对 72.5 (59.8-135.3 ) ng/ml, FMD.029 ) 独自比在渴望在 intra-IRA 组是更低的组。医院里的 LVEF 赞成了 intra-IRA 组,(45.7 湥獴眠瑩 ? 瑳 'L 敬愠杮湩 ? 慷 ? 潮 ? | YAN Hong-bing LI Shi-ying SONG Li WANG Jian WU Zheng CHI Yun-peng ZHENG Bin ZHAO Han-jun LI Qing-xiang ZHANG Xiao-jiang LI Wen-zheng | 2010 | Chinese Medical Journal2010，，7： | 50 |
| 2 | Comparison of Diver CE and ZEEK manual aspiration catheters for thrombectomy in ST-segment elevation myocardial infarction显示文摘数据的背景 A 成长体积建议直接 stenting 跟随的简单用手的血栓渴望与常规主要一种总线标准相比改进心肌的灌注和临床的结果,但是仍然有有限数据,比较在里面在不同设备之中的 vivo 性能。这研究试图由 Diver CE 比较血栓渴望的功效和操作性( Invatec , Brescia ,意大利 )并且 ZEEK ( Zeon 医药公司,东京,日本)在圣片断举起的渴望导管心肌的梗塞( STEMI )和他们到2008年6月的从2004年9月的3月的 outcome.Methods 上的影响,收到了用手的血栓渴望的有 STEMI 的 298 个连续病人涉及一个单个中心回顾的分析。他们, 229 和 69 分别地与 Diver CE 和 ZEEK 渴望导管被对待。主要端点是心肌的脸红等级(MBG ) ,在心肌的梗塞(TIMI ) 的 thrombolysis 流动等级,圣片断举起决定(STR ) ,设备 pushability 和由由把发成送气音的血栓症的尺寸分发显示了的双指南电线和渴望功效的用法的频率判定了的可跟踪性。第二等的端点是包括左室的结束的3月的结果心脏舒张的直径( LVEDD ),左室的喷射部分( LVEF ),以及心脏的死亡,目标损害 revascularization ( TLR ),主要不利心脏的事件(向) .Results 基线特征不在二个组之间是不同的重新梗塞和他们的联合为比在 Diver CE 组( Diver CE )的在 ZEEK 组( ZEEK )的暂时的心脏的踱步的更高的频率期望(0.44%对5.8%, P=0.002 )。可见检索血栓症在 65.9% Diver CE 和 68.1% ZEEK (P=0.74 ) 被完成。把发成送气音的血栓症作为小血栓症被分类(< 3.5 公里) ,中等血栓症(3.5-7.0 公里) 和大血栓症(> 7.0 公里) 。小血栓症是经常在 Diver CE (61.6% 对 42.6%) 看见的更多,而中等、更大的血栓症更经常在 ZEEK (38.4% 对 57.4%)(P=0.021 ) 被发现。双电线利用的率是 1.7% Diver CE 和 7.2% ZEEK (P=0.052 ) 。在在二个组之间的 MBG, STR 和 TIMI 流动等级没有差别。没有差别两个都在 3 月的 follow-up.Conclusions 期间在在 Diver CE 和 ZEEK 之间的心脏的死亡, TLR,重新梗塞,向, LVEDD 和 LVEF 被发现 Diver CE 和 ZEEK 用手的渴望导管为在 STEMI 的 thrombectomy 是有效的。在临床的实践, ZEEK 介绍一个更强壮的渴望能力为与 Diver CE,而是 Diver CE 显示相比节制到大血栓症向更好的 pushability 和可跟踪性的一个趋势比 ZEEK。在在在这个背景的 Diver CE 和 ZEEK 之间的渴望能力和操作性的差别不影响心肌的灌注和 3 月的结果。 | ZHAO Han-jun YAN Hong-bing WANG Jian SONG Li LI Qing-xiang LI Shi-ying CHI Yun-peng WU Zheng ZHANG Xiao-jiang ZHAO Yong ZHENG Bin | 2009 | Chinese Medical Journal2009，，6： | 25 |
| 3 | The Chrysanthemum nankingense Genome Provides Insights into the Evolution and Diversification of Chrysanthemum Flowers and Medicinal Traits显示文摘The Asteraceae (Compositae),a large plant family of approximately 24 000-35 000 species,accounts for^10% of all angiosperm species and contributes a lot to plant diversity.The most representative members of the Asteraceae are the economically important chrysanthemums (Chrysanthemum L.)that diversified through reticulate evolution.Biodiversity is typically created by multiple evolutionary mechanisms such as wholegenome duplication 0NGD)or polyploidization and locally repetitive genome expansion.However,the lack of genomic data from chrysanthemum species has prevented an in-depth analysis of the evolutionary mechanisms involved in their diversification.Here,we used Oxford Nanopore long-read technologyto sequence the diploid Chrysanthemum nankingense genome,which represents one of the progenitor genomes of domesticated chrysanthemums.Our analysis revealed that the evolution of the C.nankingense genome was driven by bursts of repetitive element expansion and WGD events including a recentWGD that distinguishes chrysanthemum from sunflower,which diverged from chrysanthemum approximately 38.8 million years ago.Variations of ornamental and medicinal traits in chrysanthemums are linked to the expansion of candidate gene families by duplication events including paralogous gene duplication.Collectively,our study of the assembled reference genome offers new knowledge and resources to dissect the history and pattern of evolution and diversification of chrysanthemum plants,and also to accelerate their breeding and improvement. | Chi Song Yifei Liu Aiping Song Gangqiang Dong Hongbo Zhao Wei Sun Shyam Ramakrishnan Ying Wang Shuaibin Wang Tingzhao Li Yan Niu Jiafu Jiang Bin Dong Ye Xia Sumei Chen Zhigang Hu Fadi Chen Shilin Chen | 2018 | Molecular Plant2018，11，12： | 24 |
| 4 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 5 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 6 | Molecular Epidemiological Characteristics of Streptococcus pyogenes Strains Involved in an Outbreak of Scarlet Fever in China,2011显示文摘Objective To investigate molecular characterization of streptococcus pyogenes isolates involved in an outbreak of scarlet fever in China in 2011.Methods Seventy-four Streptococcal pyogenes involved in an outbreak of scarlet fever were isolated from pediatric patients in the areas with high incidence in China from May to August of 2011.Emm genotyping,pulsed-field gel electrophoresis (PFGE),superantigen (SAg) genes and antimicrobial susceptibility profiling were analyzed for these isolates.Results A total of 4 different emm types were identified.Emm12 was the most prevalent type which contained four predominating PFGE patterns corresponding to four different virulence and superantigen profiles.Emm12 (79.7%) and emml (14.9%) accounted for approximately 94%of all the isolates.The speA gene was all negative in emm12 isolates and positive in emml isolates.All strains were resistant to erythromycin,and 89.4%of them were resistant to erythromycin,tracycline,and clindamycin simultaneously.Conclusion Several highly diversified clones with a high macrolide resistance rate comprise a predominant proportion of circulating strains,though no new emm type was found in this outbreak.The data provide a baseline for further surveillance of scarlet fever,which may contribute to the explanation of the outbreak and development of a GAS vaccine in China. | YOU Yuan Hai SONG Yan Yan YAN Xiao Mei WANG Hai Bin ZHANG Meng Han TAO Xiao Xia Li Lei Lei ZHANG Yu Xin JIANG Xi Hong ZHANG Bing Hua ZHOU Hao XIAO Di JIN Lian Mei FENG Zi Jian LUO Feng Ji ZHANG Jian Zhong | 2013 | Biomedical and Environmental Sciences2013，26，11： | 15 |
| 7 | COVID-19: Challenges to GIS with Big Data显示文摘The outbreak of the 2019 novel coronavirus disease(COVID-19)has caused more than 100,000 people infected and thousands of deaths.Currently,the number of infections and deaths is still increasing rapidly.COVID-19 seriously threatens human health,production,life,social functioning and international relations.In the fight against COVID-19,Geographic Information Systems(GIS)and big data technologies have played an important role in many aspects,including the rapid aggregation of multi-source big data,rapid visualization of epidemic information,spatial tracking of confirmed cases,prediction of regional transmission,spatial segmentation of the epidemic risk and prevention level,balancing and management of the supply and demand of material resources,and socialemotional guidance and panic elimination,which provided solid spatial information support for decision-making,measures formulation,and effectiveness assessment of COVID-19 prevention and control.GIS has developed and matured relatively quickly and has a complete technological route for data preparation,platform construction,model construction,and map production.However,for the struggle against the widespread epidemic,the main challenge is finding strategies to adjust traditional technical methods and improve speed and accuracy of information provision for social management.At the data level,in the era of big data,data no longer come mainly from the government but are gathered from more diverse enterprises.As a result,the use of GIS faces difficulties in data acquisition and the integration of heterogeneous data,which requires governments,businesses,and academic institutions to jointly promote the formulation of relevant policies.At the technical level,spatial analysis methods for big data are in the ascendancy.Currently and for a long time in the future,the development of GIS should be strengthened to form a data-driven system for rapid knowledge acquisition,which signifies ts that GIS should be used to reinforce the social operation parameterization of models and methods,especially when providing support for social management. | Chenghu Zhou Fenzhen Su Tao Pei An Zhang Yunyan Du Bin Luo Zhidong Cao Juanle Wang Wen Yuan Yunqiang Zhu Ci Song Jie Chen Jun Xu Fujia Li Ting Ma Lili Jiang Fengqin Yan Jiawei Yi Yunfeng Hu Yilan Liao Han Xiao | 2020 | Geography and Sustainability2020，1，1： | 13 |
| 8 | Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome显示文摘PRKAG2 心脏的症候群正染色体的主导的继承疾病在编码 γ 的 PRKAG2 基因从变化被结果;激活安培的蛋白质 kinase 的 2 规章的子单元。影响病人通常开发室的 tachyarrhythmia 并且经历对医疗倔强并且要求心脏的移植的进步的心失败。在这研究,我们与家庭 Wolff-Parkinson-White 症候群从病人在 PRKAG2 识别一个 H530R 变化。由产生转基因的 H530R PRKAG2 和敲门在里面老鼠,我们证明两个模型包括心脏的肥大和肝糖存储概括人的症状,证实 H530R 变化是有原因地与 PRKAG2 有关心脏的症候群。我们进一步联合联系 adeno 的 virus-9 (AAV9 ) 和 CRISPR/Cas9 编辑基因的系统当让野类型的等位基因未经触动时,破坏编码 H530R 的变异的 PRKAG2 等位基因。在出生后的白天的 AAV9-Cas9/sgRNA 的单个全身的注射 4 或白天 42 实质地在转基因的 H530R PRKAG2 和敲门在里面鼠标恢复心的形态学和函数。一起,我们的工作建议在 vivo CRISPR/Cas9,染色体编辑由有选择地破坏引起疾病的变化是在 PRKAG2 心脏的症候群和另外的主导的继承心脏病的治疗的一个有效工具。 | Chang Xie Ya-Ping Zhang Lu Song Jie Luo Wei Qi Jialu Hu Danbo Lu Zhen Yang Jian Zhang Jian Xiao Bin Zhou Jiu-Lin Du Naihe Jing Yong Liu Yan Wang Bo-Liang Li Bao-Liang Song Yan Yan | 2016 | Cell Research2016，26，10： | 12 |
| 9 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 10 | Efficacy and safety of trastuzumab combined with chemotherapy for first-line treatment and beyond progression of HER2-overexpressing advanced breast cancer显示文摘Objective: To observe the efficacy and safety of trastuzumab combined with chemotherapy in patients with human epidermal growth factor receptor 2(HER2)-overexpressing advanced breast cancer.Methods: A total of 90 patients with HER2-overexpressing advanced breast cancer were enrolled in this study. All patients were diagnosed with ductal invasive breast cancer by pathological analysis, and were aged between 31–73 years with a median of 51 years. HER2-positivity was defined as 3(+) staining in immunochemistry or amplification of fluorescence in situ hybridization(FISH, ratio ≥2.0). Trastuzumab was administered in combination with chemotherapy as first-line treatment and beyond progression as a secondline, third-line, and above treatment in 90, 34, 14, and 6 patients, respectively. The chemotherapy regimen was given according to normal clinical practice. The response rate was evaluated every two cycles, and the primary endpoints were progression-free survival(PFS) and overall survival(OS). Survival curves were estimated by using Kaplan-Meier graphs and were compared by using log-rank test statistics. Multivariate analysis was done using Cox's proportional hazards regression model, and the level of significance was P<0.05.Results: All 90 patients received at least one dose of trastuzumab, and efficacy could be evaluated in 85 patients. The median follow-up was 50 months. In total, 72(80.00%) patients had visceral metastasis, and 43(47.78%) patients had progressed after one or more extensive chemotherapy regimens for metastatic diseases. The median PFS for first-line trastuzumab was 10 months(range, 2–59 months), and the median OS after metastasis or initially local advanced disease was 22 months(range, 2–116 months).Conclusions: Trastuzumab combined with chemotherapy was active and well-tolerated as a first-line treatment and even beyond progression in HER2-overexpressing advanced breast cancer as a second-line or third-line treatment. However, its efficacy is certainly less beyond this point. | Huiping Li Bin Shao Yin Yan Guohong Song Xiaoran Liu Jing Wang Xu Liang | 2016 | Chinese Journal of Cancer Research2016，28，3： | 11 |
| 11 | Fabrication of Bioinspired Structured Superhydrophobic and Superoleophilic Copper Mesh for Efficient Oil-water Separation显示文摘 | Yan Song Yan Liu Bin Zhan Cigdem Kaya Thomas Stegmaier Zhiwu Han Luquan Ren | 2017 | Journal of Bionic Engineering2017，14，3： | 11 |
| 12 | Comparison of microstructures and mechanical properties of composite extruded AZ31 sheets显示文摘The microstructures and mechanical properties of the composite extruded AZ31/AZ31 and AZ31/4047 Al sheets were investigated and made a comparison to the conventional extruded AZ31 sheet.Owing to the introduced intense shear deformation at the interface during the composite extrusion,grain refinement and tilted texture were detected in AZ31 layers of the AZ31/AZ31 and AZ31/4047 Al sheets,while the conventional extruded AZ31 sheet exhibited a relative coarse,inhomogeneous microstructure and strong basal texture.The compressiontension yield ratio was increased gradually from the AZ31 to the AZ31/AZ31 and AZ31/4047 Al sheets.Besides,the AZ31/4047 Al sheet could successfully accomplish the whole bending forming process at room temperature,while the AZ31 and AZ31/AZ31 sheets were both bend-formed to failure with significant cracks in the outer tensile region under the identical bending parameters.Moreover,under the same bending strain,both the outward offset degree of strain neutral layer and the sheet thickening were more serious in the AZ31/4047 Al composite sheet than those of the AZ31 and AZ31/AZ31 sheets.The foremost reason was the quite wide gap of material properties between Mg alloy AZ31 layer(tensile loading in the outer region)and Al 4047 layer(compressive loading in the inner region). | Yanfu Chai Yan Song Bin Jiang Jie Fu Zhongtao Jiang Qingshan Yang Haoran Sheng Guangsheng Huang Dingfei Zhang Fusheng Pan | 2019 | Journal of Magnesium and Alloys2019，7，4： | 11 |
| 13 | Annual variations of black carbon over the Yangtze River Delta from 2015 to 2018显示文摘In this study,the black carbon (BC) measurements in the atmosphere of Nanjing,China were continuously conducted from 2015 to 2018 using a Model AE-33 aethalometer.By combining dataset of PM_(2.5),PM_(10),CO,NO_2,SO_2,O_3 and meteorological parameters,the temporal variations and the source apportionment of BC were given in this study.The results showed that the PM_(2.5) mass concentrations decreased in Nanjing,with an average annual rate of variation of 6.50μg/(m^3·year).Differently,the annual average concentrations of BC increased with an average annual variation rate of 214.71 ng/(m^3·year).The seasonal variations showed the pattern of BC mass concentrations in winter>autumn>spring>summer.The diurnal variations of BC mass concentrations showed a double-peak in all four seasons.The first peak occurred at approximately 7:00 in spring,summer and autumn and around 8:00 in winter.The second peak took place after 18:00.The average AAE (absorption ?ngstr?m exponent) was 1.26 with a maximum of 1.35 during wintertime and the lowest(1.12) during summertime.In addition,the AAE was smaller in the daytime than that at night,with a minimum occurring between 13:00 and 14:00.BC and visibility show a good power-function relationship at different humidity levels.The average values of the visibility thresholds of the BC mass concentrations in spring,summer,autumn and winter were 1.326,5.522,1.340 and 0.708μg/m^3,respectively.The greater the relative humidity,the smaller the visibility threshold for the BC mass concentrations was. | Yue Tan Honglei Wang Shuangshuang Shi Lijuan Shen Chen Zhang Bin Zhu Song Guo zhijun Wu Ziyi Song Yan Yin Ankang Liu | 2020 | Journal of Environmental Sciences2020，32，10： | 8 |
| 14 | Influence of Inclusion on Crack Initiation in Wheel Rim显示文摘Speed increase and heavy haul of the railway freight car are the effective measures to raise the transport ability of railway,and they have been the new trend for railway freight car development.The increase of speed and axle load will lead to the increase of wheel-rail contact stress,which will make a great change of stress distribution in the whole wheel rim.Goodier equation was employed to analyze the stress state around inclusion and cavity.In the operation of wheel-rail contact stress,stress concentration occurred in the pole of Al2O3 spherical inclusion,while it appeared on the equator of cavity.The critical inclusion sizes of 250 kN axle load freight car wheel at different velocities,a certain distance away from the tread,were calculated by Murakami equation.Comparing the inclusion in cast steel wheel with that in rolled steel wheel,it is found that the inclusion in cast steel wheel has much more excellent crack resistance than that in rolled steel wheel.In the meantime,in order to reduce the probability of rim crack,some suggestions were put forward. | MI Guo fa NAN Hong yan LIU Yan-lei ZHANG Bin ZHANG Hong SONG Guo xiang | 2011 | Journal of Iron and Steel Research(International)2011，18，1： | 8 |
| 15 | Comparison of safety and efficacy between fondaparinux and nadroparin in non-ST elevation acute coronary syndromes显示文摘心病学(ACC/AHA/ESC ) 指南的心病学 / 美国人心协会 / 欧洲人社会的背景美国学院与非圣举起在病人为使用给了 fondaparinux 一个班建议经历侵略或保守的策略的急性冠的症候群(NSTE 交流) 。Nadroparin 是在中国在 NSTE 交流使用的普通抗凝剂之一。因此,这研究在这未来的、使随机化的、开标签、单个的中心研究在病人把在 fondaparinux 和 nadroparin 之间的安全和功效与 NSTE-ACS.Methods 作比较,有NSTE交流的 300 个病人的一个总数被使随机化收到任何一个 fondaparinux (组 F , n=150 , 2.5 mg/d )或 nadroparin (组 N , n=150 , 0.1 ml/10 kgq12 h )为 4 天的一个平均数。主要安全端点是专业或在不与冠的动脉有关的 9 天的次要的流血的发生绕过 grafting (CABG ) 。主要功效端点在 9 天包括了死亡,心肌的梗塞,或周期性的局部缺血。所有病人经历了一个 180 天的 follow-up.Results 基线特征很好在二个组之间被匹配。有一不重要在在组 F 的主要安全端点的 28 相对风险减小与组 N 相比(4.7 对 6.7, HR 0.72, 95 CI0.42-1.65, P=0.38 ) 。主要功效端点在组 F 是 8.0 并且 10.0 在组 N (HR, 0.82, 95 CI0.54-1.71, P=0.49 ) 。在 9 天的安全和功效端点合成( 10.0 对 16.0 , HR 0.61 , 95 CI0.31-1.10 , P=0.10 ), 30 天( 14.0 对 17.9 , HR 0.72 , 95 C/0.47-1.16 , P=0.21 ),或 180 天( 18.7 对 27.3 , HR0.65 , 95 CI0.38-1.11 , P=0.11 )证明向在组 F.Conclusion Fondaparinux 的更低的价值的一个不重要的趋势在与 nadroparin 相比在短期、长期的后续期间流血和 ischaemic 事件与NSTE交流在病人导致了不重要的风险减小。 | YAN Hong-bing SONG Li LIU Ran ZHAO Han-jun WANG Shao-pin CHI Yun-peng ZHENG Bin LI Wen-zheng LIU Chen ZHOU Peng | 2011 | Chinese Medical Journal2011，，6： | 7 |
| 16 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 17 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 18 | Effectiveness and Safety Evaluation of Qixiong Zhongzi Decoction (芪芎种子汤) in Idiopathic Asthenozoospermia Treatment:A Randomized Controlled Trial显示文摘Objective:To evaluate the clinical effectiveness and safety of the Chinese medicine(CM)Qixiong Zhongzi Decoction(芪芎种子汤,QZD)in the treatment of patients with idiopathic asthenozoospermia.Methods:A total number of 66 patients with idiopathic asthenozoospermia were included and randomly divided into treatment and control groups by SAS-generated code from January 2015 to August 2016,33 patients in each group.Patients in the treatment group were administered with 150 m L of QZD twice a day,whereas those in the control group were given 1 g of levocarnitine oral liquid twice a day.The two groups received the indicated medication for 12 weeks and were then followed up for 4 weeks.The primary outcome was sperm motility,and the secondary therapeutic indices were sperm volume,density,pregnancy probability,and CM syndrome score.The comparison between groups was carried out at 4,8 and 12 weeks,respectively.The safety was determined before and after treatment.Results:(1)Drop-off:5 cases(7.58%)were lost after treatment(2 from the treatment group and 3 from the control group).(2)Primary outcomes:after 8-and 12-week treatment,the progressive sperms in the two groups were significantly higher than the baseline(all P<0.05);however,the treatment group showed greater improvement compared with the control group at 12-week treatment(22.7%±9.0%vs.14.1%±8.8%,P<0.05).The increasement of non-progressive grade sperms at both groups was observed at 8-and 12-week treatment with statistical difference(all P<0.05),however,the treatment group showed remarkable improvement compared with the control group at 12-week treatment(38.7%±14.1%vs.26.2%±15.4%,P<0.05).(3)Secondary outcomes:no significant statistical differences were found in semen volume and density(4,8,and 12-week treatment)and pregnancy probability of patients’wives(12-week treatment)between two groups(all P>0.05),however,the CM syndrome score of the treatment group significantly declined compared with baseline level at each time points(all P<0.05).(4)Safety:no obvious side reactions were found during the treatment in both groups.Conclusions:QZD could improve the progressive and non-progressive grade sperm in the treatment of idiopathic asthenozoospermia.It is safe with no obvious side effects. | WANG Fu GAO Qing-he GENG Qiang HAN Qiang ZHAO Jia-you YU Guo-jin ZHANG Ji-wei YAN Bin GUO Jun SONG Chun-sheng | 2020 | Chinese Journal of Integrative Medicine2020，26，2： | 6 |
| 19 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 20 | Prognostic Value of NT-proBNP in Stable Coronary Artery Disease in Chinese Patients after Percutaneous Coronary Intervention in the Drug-eluting Stent Era显示文摘Objective The predictive value of N-terminal pro-brain natriuretic peptide(NT-proBNP) in patients with stable coronary artery disease(SCAD) in the drug-eluting stent era is not yet clear. We aimed to evaluate the prognostic value of NT-proBNP in SCAD patients after percutaneous coronary intervention(PCI). Methods We examined 4,293 consecutive SCAD patients who underwent PCI between January 2013 and December 2013 in Fuwai Hospital, China. The primary endpoint was all-cause death. NT-proBNP levels were measured before PCI using Elisa kits(Biomedica, Austria). The indication for PCI was based on the degree of coronary stenosis and evidence of ischemia. Results Among 3,187 SCAD patients with NT-proBNP data, after a 2-year follow-up, NT-proBNP levels were predictive for all-cause death in the SCAD population [area under the receiver operating characteristic curve, 0.768; 95% confidence interval(CI), 0.687-0.849; P < 0.001]. At the optimum cutoff point of 732 pg/mL, the sensitivity and specificity of death was 75.0% and 72.3%, respectively. In a multivariable Cox regression model, the death hazard ratio was 6.43(95% CI, 2.99-13.82; P < 0.001) for patients with NT-proBNP levels ≥ 732 pg/mL, compared with < 732 pg/mL. Conclusion NT-proBNP is a strong predictor of 2-year death with SCAD after PCI in the drug-eluting stent era. | ZHAO Xue Yan LI Jian Xin TANG Xiao Fang XU Jing Jing SONG Ying JIANG Lin CHEN Jue SONG Lei GAO Li Jian GAO Zhan QIAO Shu Bin YANG Yue Jin GAO Run Lin XU Bo YUAN Jin Qing | 2018 | Biomedical and Environmental Sciences2018，31，12： | 5 |
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