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| 1 | Relocation of the 10 March 2011 Yingjiang,China,earthquake sequence and its tectonic implications显示文摘An earthquake with MS5.8 occurred on 10 March 2011 in Yingjiang county,western Yunnan,China.This earthquake caused 25 deaths and over 250 injuries.In order to better understand the seismotectonics in the region,we collected the arrival time data from the Yunnan seismic observational bulletins during 1 January to 25 March 2011,and precisely hand-picked the arrival times from high-quality seismograms that were recorded by the temporary seismic stations deployed by our Institute of Crustal Dynamics,China Earthquake Administration.Using these arrival times,we relocated all the earthquakes including the Yingjiang mainshock and its aftershocks using the double-difference relocation algorithm.Our results show that the relocated earthquakes dominantly occurred along the ENE direction and formed an upside-down bow-shaped structure in depth.It is also observed that after the Yingjiang mainshock,some aftershocks extended toward the SSE over about 10 km.These results may indicate that the Yingjiang mainshock ruptured a conjugate fault system consisting of the ENE trending Da Yingjiang fault and a SSE trending blind fault.Such structural features could contribute to severely seismic hazards during the moderate-size Yingjiang earthquake. | Jianshe Lei Guangwei Zhang Furen Xie Yuan Li Youjin Su Lifang Liu Honghu Ma Junwei Zhang | 2012 | Earthquake Science2012，25，1： | 35 |
| 2 | Microstructure and formation mechanism of titanium matrix composites coating on Ti-6Al-4V by laser cladding显示文摘Laser cladding experiments were done on a 5-kW continuous wave CO2 laser to synthesize TiC and TiB rein- forced titanium matrix composite coatings on Ti-6Al-4V alloy with a mixture of Ti and B4C precursor powder. The ther- modynamics of the reactions were calculated and analyzed. The microstructure and phase evolution of TiB and TiC com- posites were investigated. The results showed that the chemical reaction between Ti and B4C would release much heat, and these compounds, TiC, TiB, and small amount of TiB2, can be formed on the surface of Ti-6Al-4V alloy if the supplied en- ergy is sufficient to excite the reaction among the initial products. A good metallurgical bond between the coating and the substrate can be achieved. The microhardness of coating was irregular and the maximum value was approximately HV600. | CAI Lifang ZHANG Yongzhong SHI Likai | 2007 | Rare Metals2007，26，4： | 22 |
| 3 | Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation显示文摘apelin/apelin 受体(APJ, apelinangiotensin 像受体 1 ) 系统是一最新 deorphanized G 联合蛋白质的受体系统。是重要规章的因素的 apelin 和 APJ 在心血管的系统被表示。我们的以前的研究显著地表明了那 apelin-13 刺激脉管的光滑的肌肉房间(VSMC ) 增长。在这份报纸,我们的数据建议表明 transduction 小径的 Jagged-1/Notch3 被支持 Cyclin D1 的表示涉及 apelin-13-induced VSMC 增长。结果显示 apelin-13 在集中依赖者和时间依赖者礼貌刺激 VSMC 和 Jagged-1 和 Notch3 的表示的增长。apelin-13 导致的 Jagged-1 和 Notch3 的增加的表示能被细胞外的调整信号的蛋白质 kinase (英皇家空军之阶级最低之兵) 废除封锁。PD98059 (英皇家空军之阶级最低之兵禁止者) 能禁止 apelin-13 导致的 Jagged-1/Notch3 的激活。用小介入 RNA 的 Notch3 的下面规定禁止 Cyclin D1 的表示并且阻止 apelin-13-induced VSMC 增长。在结论, Jagged-1/Notch3 发信号 transduction 小径涉及 apelin-13 导致的 VSMC 增长。 | Lifang Li Lanfang Li Feng Xie Zidong Zhang Yu Guo Guotao Tang Deguan Lv Qixuan Lu Linxi Chen Jian Li | 2013 | Acta Biochimica et Biophysica Sinica2013，45，10： | 18 |
| 4 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 5 | Photoperiodism dynamics during the domestication and improvement of soybean显示文摘Soybean(Glycine max) is a facultative short-day plant with a sensitive photoperiod perception and reaction system, which allows it to adjust its physiological state and gene regulatory networks to seasonal and diurnal changes in environmental conditions. In the past few decades, soybean cultivation has spread from East Asia to areas throughout the world. Biologists and breeders must now confront the challenge of understanding the molecular mechanism of soybean photoperiodism and improving agronomic traits to enable this important crop to adapt to geographical and environmental changes. In this review, we summarize the genetic regulatory network underlying photoperiodic responses in soybean. Genomic and genetic studies have revealed that the circadian clock, in conjunction with the light perception pathways, regulates photoperiodic flowering. Here, we provide an annotated list of 844 candidate flowering genes in soybean, with their putative biological functions. Many photoperiod-related genes have been intensively selected during domestication and crop improvement. Finally, we describe recent progress in engineering photoperiod-responsive genes for improving agronomic traits to enhance geographic adaptation in soybean, as well as future prospects for research on soybean photoperiodic responses. | Sheng-Rui Zhang Huan Wang Zhongyu Wang Yao Ren Lifang Niu Jun Liu Bin Liu | 2017 | Science China(Life Sciences)2017，60，12： | 13 |
| 6 | Identification of immunodominant linear B-cell epitopes within the major outer membrane protein of Chlamydia trachomatis显示文摘Chlamydia trachomatis 是最流行的性播送的病原体之一。Chlamydial 主要的外部膜蛋白质(MOMP ) 能在鼠科的模型导致强壮的细胞、体液的有免疫力的回答并且被认为是一个潜在的疫苗的候选人。在这份报告, MOMP 的氨基酸顺序用帮助计算机的技术被分析扫描 B 房间 epitopes,和三可能的线性 B 房间 epitopes 肽(VLKTDVNKE, TKDASIDYHE, TRLIDERAAH ) 与高预言的 antigenicity 和高度,保存被调查。为各潜在的 epitope 编码区域的 DNA 被克隆进 pET32a (+) 并且在 Escherichia coli 表示了为 Trx-His-tag 熔化蛋白质。熔化蛋白质被 Ni-NTA agarose 祷告净化并且由 SDS 页和西方的污点分析列在后面。我们与这三熔化蛋白质使老鼠免疫。从使免疫的老鼠包含 anti-epitope 抗体的 sera 能认出 C。在 ELISA 的 trachomatis serovars D 和 E。这些熔化蛋白质的 Antisera 在 serovar E 的侵略上显示了禁止的效果由在 vitro 中立化试金。另外,浆液从恢复健康的 C 取样。感染 trachomatis 的病人与由西方的污点试金的 epitope 熔化蛋白质是反应的。我们的结果证明生物信息的分析选择的 epitope 序列是高度保存的 C。trachomatis MOMP B 房间 epitopes,并且能是子单元疫苗的发展的好候选人,它能在临床的诊断被使用。 | Shanli Zhu Jun Chen Meixia Zheng Wenci Gong Xiangyang Xue Wenshu Li Lifang Zhang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，11： | 11 |
| 7 | Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma显示文摘Background:Resistance to ferroptosis,a regulated cell death caused by irondependent excessive accumulation of lipid peroxides,has recently been linked to lung adenocarcinoma(LUAD).Intracellular antioxidant systems are required for protection against ferroptosis.The purpose of the present studywas to investigate whether and how extracellular system desensitizes LUAD cells to ferroptosis.Methods:Established human lung fibroblasts MRC-5,WI38,and human LUAD H1650,PC9,H1975,H358,A549,and H1299 cell lines,tumor and matched normal adjacent tissues of LUAD,and plasma from healthy individuals and LUAD patients were used in this study.Immunohistochemistry and immunoblotting were used to analyze protein expression,and quantitative reverse transcription-PCR was used to analyze mRNA expression.Cell viability,cell death,and the lipid reactive oxygen species generationwere measured to evaluate the responses to ferroptosis.Exosomes were observed using transmission electron microscope.The localization of arachidonic acid(AA)was detected using click chemistry labeling followed by confocal microscopy.Interactions between RNAs and proteins were detected using RNA pull-down,RNA immunoprecipitation and photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation methods.Proteomic analysis was used to investigate RNA-regulated proteins,and metabolomic analysis was performed to analyze metabolites.Cellderived xenograft,patient-derived xenograft,cell-implanted intrapulmonary LUAD mouse models and plasma/tissue specimens from LUAD patients were used to validate the molecular mechanism.Results:Plasma exosome from LUAD patients specifically reduced lipid peroxidation and desensitized LUAD cells to ferroptosis.A potential explanation is that exosomal circRNA_101093(cir93)maintained an elevation in intracellular cir93 in LUAD to modulate AA,a poly-unsaturated fatty acid critical for ferroptosisassociated increased peroxidation in the plasma membrane.Mechanistically,cir93 interacted with and increased fatty acid-binding protein 3(FABP3),which transported AA and facilitated its reaction with taurine.Thus,global AA was reduced,whereas N-arachidonoyl taurine(NAT,the product of AA and taurine)was induced.Notably,the role of NAT in suppressing AA incorporation into the plasma membrane was also revealed.In pre-clinical in vivo models,reducing exosome improved ferroptosis-based treatment.Conclusion:Exosome and cir93 are essential for desensitizing LUAD cells to ferroptosis,and blocking exosome may be helpful for future LUAD treatment. | Xiao Zhang Yunhua Xu Lifang Ma Keke Yu Yongjie Niu Xin Xu Yi Shi Susu Guo Xiangfei Xue Yikun Wang Shiyu Qiu Jiangtao Cui Hong Wang Xiaoting Tian Yayou Miao Fanyu Meng Yongxia Qiao Yongchun Yu Jiayi Wang | 2022 | Cancer Communications2022，42，4： | 10 |
| 8 | Hypoxia promotes bone marrow-derived mesenchymal stem cell proliferation through apelin/APJ/autophagy pathway显示文摘骨头导出髓的间充质的干细胞(BMSC ) 是有增长和区别的能力进间充质的系房间的 multipotent 祖先的一张人口。规章的肽 apelin 是为 G 联合蛋白质的受体 APJ 的内长的 ligand。Apelin,能提高 BMSC 增长,在许多房间类型上有 mitogenic 效果。我们假设了增加的 apelin/APJ 可能涉及导致组织缺氧的 BMSC 增长的出现和发展。从到 10-week-old C57BL/6J 老鼠的 8- 的骨头髓的 BMSC 在 normoxia (21% 氧) 或组织缺氧(1% 氧) 下面是有教养的状况。房间增长被 3-(4,5-dimethylthiazol-2-yl ) 决定 -2,5-diphenyltetrazolium 溴化物试金和 5-bromo-2-deoxyuridine 试金。组织缺氧可诱导的因素(HIF ) 的表情 -1, apelin, APJ, Beclin-1,和 LC3II/LC3I 被西方的污点分析检测。结果建议组织缺氧以一种时间依赖者方式提高了 BMSC 的增长。HIF-1, apelin, APJ, Beclin-1,和 LC3II/LC3I 的表情在组织缺氧导致的 BMSC 被增加。禁止了 apelin, APJ, Beclin-1,和 LC3II/LC3I 的导致组织缺氧的表情的小介入 RNA (siRNA )-HIF-1 阻止了导致组织缺氧的 BMSC 增长。禁止了 Beclin-1 和 LC3II/LC3I 的导致组织缺氧的表情的 siRNA-APJ 颠倒了导致组织缺氧的 BMSC 增长。siRNA-Beclin-1 也废除了导致组织缺氧的房间增长。这些数据建议表明小径的 apelin/APJ/autophagy 可能涉及导致组织缺氧的 BMSC 增长。 | Lanfang Li Lifang Li Zidong Zhang Zhisheng Jiang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，5： | 10 |
| 9 | The Post-meiotic Deficicent Anther1 (PDA1) gene is required for post-meiotic anther development in rice显示文摘To understand the molecular mechanism of male reproductive development in the model crop rice,we isolated a complete male sterile mutant post-meiotic deficient anther1 (pda1) from a γ-ray-treated rice mutant library.Genetic analysis revealed that the pda1 mutant was controlled by a recessive nucleus gene.The pda1 mutant anther seemed smaller with white appearance.Histological analysis demonstrated that the pda1 mutant anther undergoes normal early tapetum development without obvious altered meiosis.However,the pda1 mutant displayed obvious defects in postmeiotic tapetal development,abnormal degeneration occurred in the tapetal cells at stage 9 of anther development.Also we observed abnormal lipidic Ubisch bodies from the tapetal layer of the pda1 mutant,causing no obvious pollen exine formation.RT-PCR analysis indicated that the expression of genes involved in anther development including GAMYB,OsC4 and Wax-deficient anther1 (WDA1) was greatly reduced in the pda1 mutant anther.Using map-based cloning approach,the PDA1 gene was finely mapped between two markers HLF610 and HLF627 on chromosome 6 using 3,883 individuals of F2 population.The physical distance between HLF610 and HLF627 was about 194 kb.This work suggests that PDA1 is required for post-meiotic tapetal development and pollen/microspore formation in rice. | Lifang Hu Hexin Tan Wanqi Liang Dabing Zhang | 2010 | Journal of Genetics and Genomics2010，37，1： | 8 |
| 10 | Glycerol aerobic oxidation to glyceric acid over Pt/hydrotalcite catalysts at room temperature显示文摘Glycerol(GLY) aerobic oxidation in an aqueous solution is one of the most prospective pathways in biomass transformation, where the supported catalysts based on noble metals(mainly Au, Pd, Pt) are most commonly employed. Herein, Pt nanoparticles supported on rehydrated MgxAl1-hydrotalcite(denoted as re-MgxAl1-LDH-Pt) were prepared via impregnation-reduction method followed by an in situ rehydration process, which showed high activity and selectivity towards GLY oxidation to produce glyceric acid(GLYA) at room temperature. The metal-support interfacial structure and catalyst basicity were modulated by changing the Mg/Al molar ratio of the hydrotalcite precursor, and the optimal performance was achieved on re-Mg6Al1-LDH-Pt with a GLY conversion of 87.6% and a GLYA yield of 58.6%, which exceeded the traditional activated carbon and oxide supports. A combinative study on structural characterizations(XANES, CO-FTIR spectra, and benzoic acid titration) proves that a higher Mg/Al molar ratio promotes the formation of positively charged Ptd+species at metal-support interface, which accelerates bond cleavage of a-C–H and improves catalytic activity. Moreover, a higher Mg/Al molar ratio provides a stronger basicity of support that contributes to the oxidation of terminal-hydroxyl and thus enhances the selectivity of GLYA. This catalyst with tunable metal-support interaction shows prospective applications toward transformation of biomass-based polyols. | Junbo Zhang Xiaolin Li Ming Xu Yusen Yang Yinwen Li Ning Liu Xiaoyu Meng Lifang Chen Shuxian Shi Min Wei | 2019 | Science Bulletin2019，64，23： | 8 |
| 11 | cDNA microarray reveals the alterations of cytoskeleton-related genes in osteoblast under high magneto-gravitational environment显示文摘为模仿减少的严肃环境的一个新奇基于地面的模型广泛地在许多地里被使用了的抗磁的悬浮。在这研究,一个专辑设计了超导的磁铁,它能生产三个明显的严肃层次(0, 1,和 2 g ) ,也就是高的磁电机重力的环境(HMGE ) ,被用来模仿空间严肃环境。造骨细胞基因表示侧面上的 HMGE 的效果被 microarray 调查。对抗磁的悬浮环境(0 g ) 敏感的基因,严肃变化,和高磁场变化根据典型房间功能被排序。作为细胞内部的忍受负担的结构,细胞骨架在严肃感觉起一个重要作用。因此, 13 细胞骨架相关的基因根据 microarray 分析的结果被选择,并且这些基因的表情被发现被即时 PCR 在 HMGE 下面改变。基于 PCR 结果, WASF2 的表情(是蛋白质家庭,成员 2 ) , WIPF1 (WAS/WASL 交往蛋白质家庭,成员 1 ) , paxillin,和 talin 1 被西方的污点试金进一步识别。结果显示了那 WASF2, WIPF1 对改变的严肃层次,和 talin 更敏感 1 并且 paxillin 对磁场和严肃变化敏感。我们的调查结果证明 HMGE 能影响造骨细胞基因表示侧面和细胞骨架相关的基因表示。mechanosensitive 基因的鉴定可以提高我们的理解到 microgravity 导致的骨头损失的机制并且可以为阻止并且对待骨头损失或骨质疏松症提供一些潜在的目标。 | Airong Qian Shengmeng Di Xiang Gao Wei Zhang Zongcheng Tian Jingbao Li Lifang Hu Pengfei Yang Dachuan Yin Peng Shang | 2009 | Acta Biochimica et Biophysica Sinica2009，41，7： | 8 |
| 12 | Multi-epitope vaccines: a promising strategy against tumors and viral infections显示文摘Immune responses play a critical role in fighting tumors and viral infections.An antigenic epitope is a basic unit that elicits either a cellular or a humoral immune response.A multi-epitope vaccine composed of a series of or overlapping peptides is therefore an ideal approach for the prevention and treatment of tumors or viral infections.1,2,3,4,5 Although some multi-epitope vaccines have entered phase I clinical trials,for example,EMD640744 in patients with advanced solid tumors,6 designing efficacious multi-epitope vaccines remains a great challenge.An ideal multi-epitope vaccine should be designed to include epitopes that can elicit CTL,Th and B cells and induce effective responses against a targeted tumor or virus(Figure 1). | Lifang Zhang | 2018 | Cellular & Molecular Immunology2018，15，2： | 8 |
| 13 | Natural continuous influent nitrifier immigration effects on nitrification and the microbial community of activated sludge systems显示文摘Two sequencing batch reactors(SBRs) were operated for 100 days under aerobic conditions,with one being fed with unsterilized municipal wastewater(USBR), and the other fed with sterilized municipal wastewater(SSBR). Respirometric assays and fluorescence in situ hybridization(FISH) results show that active nitrifiers were present in the unsterilized influent municipal wastewater. The maximum ammonia utilization rate(AUR) and nitrite utilization rate(NUR) of the unsterilized influent were 0.32 ± 0.12 mg NH4+-N/(L·hr) and0.71 ± 0.18 mg NO2--N/(L·hr). Based on the maximum utilization rates, the estimated seeding intensity for the ammonia oxidizing bacteria(AOB) and nitrite oxidizing bacteria(NOB) of the USBR was 0.08 g AOB/(g AOB·day) and 0.20 g NOB/(g NOB·day) respectively. The fraction of nitrifiers/total bacteria in the influent was 5.35% ± 2.1%, the dominant AOB was Nitrosomonas spp., Nitrosococcus mobilis hybridizated with Nsm156, and the dominant NOB was Nitrospira hybridizated with Ntspa662. The influent nitrifiers potentially seeded the activated sludge of the bioreactor and hence demonstrated a mitigation of the acclimatization times and instability during start-up and early operation. The AUR and NUR in the USBR was 15% and 13% higher than the SSBR respectively during the stable stage, FISH results showed that nitrifiers population especially the Nitrospira in the USBR was higher than that in the SSBR. These results indicate that the natural continuous immigration of nitrifiers from municipal influent streams may have some repercussions on the modeling and design of bioreactors. | Lifang Yu Ren Li Robert Delatolla Ru Zhang Xiuling Yang Dangcong Peng | 2018 | Journal of Environmental Sciences2018，30，12： | 7 |
| 14 | Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity of Ebola virus glycoprotein in vitro显示文摘Ebola virus(EBOV)causes a highly lethal hemorrhagic fever syndrome in humans and has been associated with mortality rates of up to 91%in Zaire,the most lethal strain.Though the viral envelope glycoprotein(GP)mediates widespread inflammation and cellular damage,these changes have mainly focused on alterations at the protein level,the role of microRNAs(miRNAs)in the molecular pathogenesis underlying this lethal disease is not fully understood.Here,we report that the miRNAs hsa-miR-1246,hsa-miR-320a and hsa-miR-196b-5p were induced in human umbilical vein endothelial cells(HUVECs)following expression of EBOV GP.Among the proteins encoded by predicted targets of these miRNAs,the adhesion-related molecules tissue factor pathway inhibitor(TFPI),dystroglycan1(DAG1)and the caspase 8 and FADD-like apoptosis regulator(CFLAR)were significantly downregulated in EBOV GP-expressing HUVECs.Moreover,inhibition of hsa-miR-1246,hsa-miR-320a and hsa-miR-196b-5p,or overexpression of TFPI,DAG1 and CFLAR rescued the cell viability that was induced by EBOV GP.Our results provide a novel molecular basis for EBOV pathogenesis and may contribute to the development of strategies to protect against future EBOV pandemics. | SHENG MiaoMiao ZHONG Ying CHEN Yang DU JianChao JU XiangWu ZHAO Chen ZHANG GuiGen ZHANG LiFang LIU KangTai YANG Ning XIE Peng LI DangSheng ZHANG Michael Q. JIANG ChengYu | 2014 | Science China(Life Sciences)2014，57，10： | 7 |
| 15 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 16 | Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling显示文摘室的肥大是心血管的疾病的事件的一个强大、独立的预言者。低剂量的乙酰水杨酸酸(阿司匹林) 的脉管的性质通过血小板 cyclooxygenase 的不可逆的抑制提供心血管的好处 1;然而,可能的 anti-hypertrophic 性质和阿司匹林的潜在的机制没详细被调查。在这研究,健康野类型的雄的老鼠随机被划分成三个组并且使遭到了到横向的大动脉的收缩(TAC ) 或假冒的操作。操作 TAC 的老鼠与低剂量的阿司匹林的人的等价物被对待(10 mg 吗? | Samuel Chege Gitau Xuelian Li Dandan Zhao Zhenfeng Guo Haihai Liang Ming Qian Lifang Lv Tianshi Li Bozhi Xu Zhiguo Wang Yong Zhang Chaoqian Xu Yanjie Lu Zhiming Du Hongli Shan Baofeng Yang | 2015 | Frontiers of Medicine2015，9，4： | 6 |
| 17 | Comprehensive reform of community health service in east,middle and west regions of China:from patients’perspective显示文摘Objectives:To analyze the satisfaction of patients with community health service(CHS)and the changes of the CHS delivered before and after the new health reform in different regions of China,and to put forward relevant policy recommendations for CHS development.Methods:Twelve community health centers were selected by random sampling in each of the eight typical cities in the east,middle and west regions of China.Questionnaire survey was conducted among patients visiting these institutions during daily work hours.Results:The proportions of the participants who stated that the medical environment,service attitude and medical skills of the doctors were improved were higher in the west region than those of the east and middle regions;but the percentage of patients who held that the drug price had lowered was higher in the east region than those of the middle and west region,the differences were of statistical significance(P<0.0125).The patients’satisfaction rates with medical environment,service attitude,and technical skills of the medical staff in the west region were 88.9%,91.5%and 81.6%respectively,which were higher than those in the east and middle regions.In the east region,the satisfaction rate with the reimbursement for this visit was 58.5%,which was highest among the three regions;in the west region,patients’satisfaction rates with drug types and preventive care were 51.5%and 65.9%,respectively,which was significantly higher than those in the east and middle regions(P<0.0125).As recommended by the participants,the top three aspects of health services that need to be improved were drug type and quality(25.3%),drug prices(21.8%)and technical skills(18.2%)in the east region;infrastructure(28.2%),drug prices(21.8%)and drug types and quality(21.2%)in the middle region;infrastructure(30.8%),drug types and quality(28.1%)and reimbursement(27.9%)in the west region.Conclusions:The comprehensive CHS reform should take the opinions of patients into account;essential drug system should be consolidated continually;and the reform of the payment system should be promoted by actively cooperating with the health insurance organizations. | JIANGMEI QIN YANCHUN ZHANG LIFANG ZHANG LIQUN LIU WEI ZHOU CAILING LIU LIKUN WANG JING LI | 2013 | Family Medicine and Community Health2013，1，2： | 6 |
| 18 | Cross-sectional survey of the relationship of symptomatology, disability and family burden among patients with schizophrenia in Sichuan, China显示文摘 | Zhuoqiu ZHANG Hong DENG Ying CHEN Shuiying LI Qian ZHOU Hua LAI Lifang LIU Ling LIU wenwu SHEN | 2014 | 上海精神医学2014，26，1： | 6 |
| 19 | Advances in COVID-19 mRNA vaccine development显示文摘To date,the coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has determined 399,600,607 cases and 5,757,562 deaths worldwide.COVID-19 is a serious threat to human health globally.The World Health Organization(WHO)has declared COVID-19 pandemic a major public health emergency.Vaccination is the most effective and economical intervention for controlling the spread of epidemics,and consequently saving lives and protecting the health of the population.Various techniques have been employed in the development of COVID-19 vaccines.Among these,the COVID-19 messenger RNA(mRNA)vaccine has been drawing increasing attention owing to its great application prospects and advantages,which include short development cycle,easy industrialization,simple production process,flexibility to respond to new variants,and the capacity to induce better immune response.This review summarizes current knowledge on the structural characteristics,antigen design strategies,delivery systems,industrialization potential,quality control,latest clinical trials and real-world data of COVID-19 mRNA vaccines as well as mRNA technology.Current challenges and future directions in the development of preventive mRNA vaccines for major infectious diseases are also discussed. | Enyue Fang Xiaohui Liu Miao Li Zelun Zhang Lifang Song Baiyu Zhu Xiaohong Wu Jingjing Liu Danhua Zhao Yuhua Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 5 |
| 20 | Chemical and boron isotopic compositions of tourmaline in the Longtoushan hydrothermal gold deposit, Guangxi, China:implications for gold mineralization显示文摘The Longtoushan hydrothermal gold deposit is located in the southwestern region of the Dayaoshan Uplift.Tourmaline is widespread in the Longtoushan gold deposit and is mainly distributed in the rhyolite porphyry and associated cryptoexplosive breccia. The spatial distribution of tourmaline enrichment is similar to that of the gold orebody. Feldspar has been largely replaced by tourmaline in the rhyolite porphyry and cryptoexplosive breccia.Electron microprobe analysis revealed that tourmalines in the Longtoushan deposit belong mainly to the alkali group and partly to the X-vacant group; they mostly fell in the schorl-dravite series field. Two distinct sets of dominant substitutions were observed: MgFe_(-1) and Al□(NaR2+)-1,where R = Fe, Mg. In addition, minor substitutions include(CaMg)(NaAl)_(-1) and FeAl_(-1). The calculated d11 B value for the mineralizing fluids ranged from-12.8 to-9.7%,which is typical of S-type granites, and boron-enriched fluids predominantly derived from rhyolitic melt. Part of the tourmaline from the rhyolite porphyry crystallized during the magmatic-hydrothermal stage, whereas most tourmalines from the deposit formed in the post-magmatic hydrothermal stage. The tourmalines were deposited from a relatively reduced and acidic fluid system, and the gold predominantly precipitated during the post-magmatic hydrothermal stage in the Longtoushan deposit. | Lihua Qian Jianqing Lai Shugen Zhang Lifang Hu Rong Cao Shilong Tao | 2019 | Acta Geochimica2019，38，2： | 5 |
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